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Negative regulator of sphingolipid synthesis. Additionally we are shipping ORMDL3 Antibodies (23) and ORMDL3 Kits (1) and many more products for this protein.
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ORMDL3 overexpression is associated with asthma.
The TT homozygote and the T allele of rs7216389 in ORMDL3 increased bronchiolitis risk. The rs7216389 polymorphism may be a predictor for identifying infants with predisposition to virus-induced wheezing to persistent asthma.
Two single nucleotide polymorphisms regulating ORMDL3 expression (rs7216389 and rs9303277) significantly associated with atherosclerosis risk and the evidence of increased ORMDL3 expression in AS cases compared to controls.
The SNP (rs7216389) of ORMDL3 does not influence the expression of OPN (show SPP1 Proteins) and TGF-beta1 (show TGFB1 Proteins), suggesting that it may not be associated with airway remodeling.
ORMDL3 variants have been shown to be associated with Asthma in children with Rhinovirus infections -induced wheezing illnesses.
The meta-analysis indicates that ORMDL3 rs7216389 may contribute to increasing susceptibility to asthma. (Meta-analysis)
the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism
results show that Cbl-b suppresses human ORMDL3 expression through STAT6 (show STAT6 Proteins)
Pro-inflammatory gene ORMDL3 SNP rs12603332 may be associated with high LysoPC and apoB (show APOB Proteins) levels, which leads to the occurrence of childhood asthma.
Results confirmed the genetic association between GSDMB (show GSDMB Proteins)/ ORMDL3 and childhood asthma and show significant differences in the DNA methylation (show HELLS Proteins) levels of ORMDL3 promoter of asthmatic children.
Downregulation of ORMDL3 expression in mast cells enhances AKT (show AKT1 Proteins) and NF-kappaB (show NFKB1 Proteins)-directed signaling pathways and chemotaxis and contributes to the development of mast cell-mediated local inflammation in vivo.
overexpression of ORMDL3 regulates ceramide homeostasis in cells in a complex manner and suggest that local FTY720 administration might be a useful therapeutic intervention for the control of allergic asthma.
These studies provide evidence that ORMDL3 plays an important role in vivo in airway remodeling potentially through ATF6 (show ATF6 Proteins) target genes.
ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18 (show ITGB2 Proteins), CD49d, and CD48 (show CD48 Proteins).
signaling pathway cAMP/PKA/CREB (show CREB1 Proteins) plays an important role in regulating ORMDL3 expression
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).
ORM1-like protein 3
, liver regeneration-related protein LRRGT00183