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Negative regulator of sphingolipid synthesis. Additionally we are shipping ORMDL3 Antibodies (24) and ORMDL3 Kits (1) and many more products for this protein.
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These studies suggest that increased levels of ORMDL3 contribute to antiviral defense to rhinovirus infection in mice (hORMDL3(zp3 (show ZP3 Proteins)-Cre) mice which have universal increased expression of human ORMDL3) through pathways that may include IFNs (IFN-alpha (show IFNA Proteins), IFN-beta (show IFNB1 Proteins), IFN-lambda), OAS (show SMOC1 Proteins), and RNAse L (show RNASEL Proteins).
this study demonstrated the upregulation of (show ATF6 Proteins) ORMDL3 (show BECN1 Proteins)in patients with systemic lupus erythematosus
ORMDL3 might influence de novo sphingolipid metabolism downstream of serine palmitoyltransferase
modest changes (8-13%) in promoter methylation levels of ZPBP2 (show ZPBP2 Proteins) and GSDMA (show GSDMA Proteins) may cause substantial changes in RNA levels and allelic expression of ZPBP2 (show ZPBP2 Proteins) and ORMDL3 is mediated by DNA methylation (show HELLS Proteins)
Decreased ORMDL3 expression increased levels of free sphingoid bases and sphingoid base phosphates, and also caused increases in cellular levels of ceramides.
ORMDL3 overexpression is associated with asthma.
The TT homozygote and the T allele of rs7216389 in ORMDL3 increased bronchiolitis risk. The rs7216389 polymorphism may be a predictor for identifying infants with predisposition to virus-induced wheezing to persistent asthma.
Two single nucleotide polymorphisms regulating ORMDL3 expression (rs7216389 and rs9303277) significantly associated with atherosclerosis risk and the evidence of increased ORMDL3 expression in AS cases compared to controls.
The SNP (rs7216389) of ORMDL3 does not influence the expression of OPN (show SPP1 Proteins) and TGF-beta1 (show TGFB1 Proteins), suggesting that it may not be associated with airway remodeling.
ORMDL3 variants have been shown to be associated with Asthma in children with Rhinovirus infections -induced wheezing illnesses.
ORMDL3 mediates the autophagy via the ATF 6 (show ATF6 Proteins)-Beclin1 (show BECN1 Proteins) autophagy pathway, and it facilitates the survival of splenic B cells via promoting autophagy and suppressing apoptosis
inhibiting ORMDL3 in airway epithelial cells plays a significant role in induction of allergen-induced increases in airway hyperresponsiveness
ORMDL3, an asthma susceptibility gene identified by genome-wide association studies, contributes to key pathways that promote changes in airway physiology during allergic immune responses.
Mediated by GATA3 (show GATA3 Proteins) through targeting promoter region of ORMDL3.
Downregulation of ORMDL3 expression in mast cells enhances AKT (show AKT1 Proteins) and NF-kappaB (show NFKB1 Proteins)-directed signaling pathways and chemotaxis and contributes to the development of mast cell-mediated local inflammation in vivo.
overexpression of ORMDL3 regulates ceramide homeostasis in cells in a complex manner and suggest that local FTY720 administration might be a useful therapeutic intervention for the control of allergic asthma.
the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism
These studies provide evidence that ORMDL3 plays an important role in vivo in airway remodeling potentially through ATF6 (show ATF6 Proteins) target genes.
ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18 (show ITGB2 Proteins), CD49d, and CD48 (show CD48 Proteins).
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).
ORM1-like protein 3
, liver regeneration-related protein LRRGT00183