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Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. Additionally we are shipping ODAM Proteins (7) and ODAM Kits (4) and many more products for this protein.
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ODAM induced RhoA (show RHOA Antibodies) activity. ODAM-mediated RhoA (show RHOA Antibodies) signalling resulted in actin filament rearrangement, increased cell adhesion and inhibited the migration/invasion of MCF7 cells. These results suggest that ODAM expression maintains their adhesion, resulting in the prevention of their metastasis via the regulation of RhoA (show RHOA Antibodies) signalling in breast cancer cells.
We propose that ODAM has diverse functions that vary with protein location in various cell lines. Nuclear ODAM appears to be associated with MMP-20 (show MMP20 Antibodies) regulation and tumorigenesis. Additional functions may take place in cytoplasm and extracellular matrix.
Our studies demonstrate that ectopic ODAM expression in melanoma cell lines suppresses growth and migratory activity in these cells, while eliciting elevated PTEN (show PTEN Antibodies) expression and suppression of AKT (show AKT1 Antibodies) activity.
The expression of APIN at an early time-point following disruption of periodontal integrity suggests that this protein may be part of the cascade of events leading to the activation of ERM (show ETV5 Antibodies) during periodontal healing and regeneration
Calcifying epithelial odontogenic tumor-associated amyloid consists of a unique and previously undescribed protein that we provisionally designate APin.
The protein sequences deduced from the cloned cDNA for rat, mouse, pig, and human were aligned together with those obtained from four other mammal genomes. Apin is highly conserved in mammals.
Data suggest that ODAM is a developmental antigen that has an essential role in tooth maturation and in the pathogenesis of certain odontogenic and other epithelial neoplasms
Confirmation of the amyloidogenic potential of ODAM has resulted from analyses of four other cases where we found, in addition, a 74-residue segment specified by exon 4.
the BMP-2 (show BMP2 Antibodies)-BMPR-IB (show BMPR1B Antibodies)-ODAM-MAPK (show MAPK1 Antibodies) signaling cascade has important roles in ameloblast differentiation and enamel mineralization
ODAM and AMTN are bona fide components of the basal lamina associated with maturation stage ameloblasts and they organize into different subdomains during the early maturation stage.
Runx2 (show RUNX2 Antibodies) regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 (show MMP20 Antibodies) apart from a different, currently unidentified, function of extracellular ODAM.
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process.
odontogenic ameloblast-associated protein