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Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (By similarity).. Additionally we are shipping OIP5 Antibodies (16) and many more products for this protein.
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OIP5 over-expression inhibited hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1 (show NOTCH1 Proteins), which was a core oncogene (show RAB1A Proteins) in promoting breast cancer progression.
Stable binding of Mis18alpha (show MIS18A Proteins)-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A (show CENPA Proteins) deposition.
Over-expression of OIP5 was observed in breast tumors.
Mis18beta binds with and specifies the centromere localization of HJURP (show HJURP Proteins).
this study showed betaTrCP (show BTRC Proteins)-mediated regulation of Mis18beta stability is a mechanism to restrict centromere function of Mis18 complex from late mitosis to early G1 phase.
expression of AURKC (show AURKC Proteins), OIP5, PIWIL2 and TAF7L (show TAF7L Proteins) differed between patients with Acute myeloid leukemia (show BCL11A Proteins), myelodysplastic syndrome and healthy controls in a gender-dependent manner
OIP5 expression was significantly associated with poor prognosis of lung and esophageal cancer patients
These results indicate that knockdown of OIP5 may induce apoptosis in cancer cells.
Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha (show MIS18A Proteins), hMis18beta, and M18BP1 (show MIS18BP1 Proteins), the complex of which is accumulated specifically at the telophase-G1 centromere, are identified.[Mis18alpha (show MIS18A Proteins), Mis18beta, M18BP1 (show MIS18BP1 Proteins)]
Increase of Oip5 may associate with development of obesity.
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (By similarity).
, Opa interacting protein 5
, LAP2alpha interactor-25
, MIS18 kinetochore protein homolog B
, cancer/testis antigen 86
, opa-interacting protein 5
, opa-interacting protein 5 homolog