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a class of opioid receptors\; show selective affinity for the endogenous opioid dynorphin [RGD, Feb 2006].. Additionally we are shipping Opioid Receptor, kappa 1 Antibodies (118) and Opioid Receptor, kappa 1 Kits (4) and many more products for this protein.
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ZFOR3 is a unique model to study kappa opioid receptor functionality
These findings provide evidence that previously demonstrated KOR-mediated reduction in intraocular pressure could be caused, in part, by NO production in both the ciliary body and the trabecular meshwork.
Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2 (show ARRB2 Proteins)-signaling pathway.
Hypoxia inducible factor-1alpha (HIF-1alpha (show HIF1A Proteins)) siRNA knocked down the increase of endogenous HIF-1alpha (show HIF1A Proteins) messages and diminished the desferrioxamine (DFO)-induced increase of kappa-opioid receptor (hKOR) expression.
genetic association studies in a population in Denmark: Data suggest that carriers/heterozygotes of the C allele (CC/CT) of OPRK SNP rs6473799 report a 30.4% higher mechanical visceral pain tolerance threshold than non-carriers.
Molecular switches of the kappa opioid receptor triggered by 6'-GNTI (show MGAT1 Proteins) and 5'-GNTI (show MGAT1 Proteins) have been described.
The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1, OPRK1, OPRD1) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone.
findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS (show SCN9A Proteins) severity.
OPRK1 promoter hypermethylation might increase the risk of AD through its regulation on the gene expression of OPRK1.
OX1R (show HCRTR1 Proteins) and KOR heterodimerize, and this heterodimer associates with Galphas (show GNAS Proteins), leading to increased protein kinase A (PKA) signaling pathway activity, including upregulation of intracellular cAMP levels.
The structure of the dynorphin (1-13) peptide (dynorphin) bound to the human kappa opioid receptor (KOR) has been determined by liquid-state NMR spectroscopy.
RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling.
This study reports a cluster of compounds that are highly effective in enhancing remyelination and identifies kappa-opioid receptor (KOR) as a positive regulator for oligodendroglial differentiation, implicating KOR agonism as a potential strategy to accelerate remyelination.
GRK2 (show ADRBK1 Proteins) upregulation causes kappa-opioid receptor desensitization in diabetic heart
Study showed that Dyn (show PDYN Proteins)-A, the endogenous kappa opioid receptor agonist, significantly hyperpolarized and inhibited neurons in the paraventricular nucleus of mouse thalamus
Suggest that mixed cardiac ion channel blockade my mediated the antiarrhythmia actions of kappa-opioid receptor antagonist PD117,302.
Anti-nociception mediated by a KOR agonist is blocked by a DOR agonist
Findings suggest that activation of kappa opioid receptor (kappa-opioid receptor) reduces hyperglycemia in streptozotocin-induced diabetic mice.
findings show that, during prolonged heroin abstinence, delta opioid receptors regulate hedonic homeostasis, while mu opioid receptor (show OPRM1 Proteins) signaling in serotonergic pathways and kappa opioid receptors together control social behaviors
kappa-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice.
The data of this study provide evidence that KORs on VTA DA neurons are necessary to mediate KOR-mediated aversive behavior.
Natural food reward and systemic ghrelin (show GHRL Proteins) activate Kappa opioid receptors in the ventral tegmental area.
a class of opioid receptors\; show selective affinity for the endogenous opioid dynorphin
, kappa-type opioid receptor
, opioid receptor, kappa 1
, kappa opioid receptor
, Opiate receptor, kappa-1
, opioid receptor, kappa 2