You are viewing an incomplete version of our website. Please click to reload the website as full version.

Opsin 4 Proteins (OPN4)

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. Additionally we are shipping OPN4 Antibodies (17) and OPN4 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat OPN4 OPN4 192223 Q8R456
OPN4 94233 Q9UHM6
OPN4 30044 Q9QXZ9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top OPN4 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days

OPN4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine) ,

More Proteins for Opsin 4 (OPN4) Interaction Partners

Zebrafish Opsin 4 (OPN4) interaction partners

  1. Melanopsin photostimulation triggers the phosphoinositide pathway through activation of a G-Protein, G11 (show STK19 Proteins).

  2. The opn4a gene is expressed continuously from 1 to 3 dpf in the presumptive preoptic area, as defined by coexpression of the orthopedia homolog (otp) gene.

  3. description of the discovery and functional characterisation of a new melanopsin gene in fish, bird, and amphibian genomes, demonstrating that vertebrates have evolved two quite separate melanopsins

Turkey Opsin 4 (OPN4) interaction partners

  1. Expressed locally in the premammillary nucleus of the hypothalamus in temperate zone birds, melanopsin is an important regulator of reproductive activity.

Human Opsin 4 (OPN4) interaction partners

  1. The light-induced FOS response in melanopsin expressing HEK (show EPHA3 Proteins)-293 cells is correlated with melanopsin quantity and dependent on light duration and irradiance.

  2. By broadening the tuning of intrinsically photosensitive retinal ganglion cells, melanopsin tristability produces signal integration.

  3. The response of the human pupil to the separate stimulation of the cones and melanopsin at a range of temporal frequencies under photopic conditions, was measured.

  4. Studied OPN4*Ile394Thr gene polymorphism in association with sleep/wake timing.

  5. The results of this study showed that the post illumination pupil response varied on the basis of OPN4 I394T genotype among individuals with seasonal affective disorder.

  6. Studied the association between melanopsin gene polymorphism and pupillary light reflex under diverse photic conditions, including different intensities and wavelengths.

  7. A comparison of melanopsin with the mechanisms documented for vertebrate (bovine) and invertebrate (squid) visual photoreceptors shows that such a mechanism is not affected by the diversity of the three chromophore cavities.

  8. An action spectrum for the calcium response in cells expressing human melanopsin had the predicted form for an opsin : vitamin A1 pigment and peaked at 479 nm. The G-protein selectivity and spectral sensitivity of human melanopsin is similar to that previously described for rodents.

  9. the results indicate that ectopic expression of human OPN4 in orexin neurons enables long-lasting activation of orexin neurons by blue light to control sleep/wakefulness of the mice.

  10. These results suggest that the P10L TT genotype of melanopsin interacts with daylength to predispose individuals to vary in sleep onset and chronotype as a function of daylength.

Mouse (Murine) Opsin 4 (OPN4) interaction partners

  1. Melanopsin overexpression in RGCs enhanced the amplitude and duration of their light response, and silencing them with Kir2.1 (show KCNJ2 Proteins) significantly suppressed the increased mTOR (show FRAP1 Proteins) signaling and axon regeneration that were induced by melanopsin

  2. mice null for melanopsin (Opn4-/-), lost significantly more weight than wild-type controls or mice lacking rod and cone photoreceptors.

  3. These results suggest GRK2 (show ADRBK1 Proteins) contributes to melanopsin deactivation, but that other mechanisms account for most of modulation of melanopsin activity in ipRGCs.

  4. Using a combination of conventional knockout, chemogenetic, and receptor-silent substitution manipulations, we continued to show that, over higher irradiances, this increase in firing originates with inner-retinal melanopsin photoreception

  5. Opn4 mediates wavelength-specific, light-dependent vascular relaxation.

  6. Data indicate that retinal molecular circadian clock can be entrained by lighting cycles in vitro, but that rods, cones, and melanopsin (Opn4) are not required for this entrainment.

  7. critical phosphorylation sites on the carboxy tail of melanopsin

  8. Melanopsin Is required for normal Sensitivity and expression in alpha retinal ganglion cells.

  9. the role of melanopsin-expressing retinal ganglion cells in the glaucoma-induced depressive behavioral response pattern was investigated

  10. melanopsin is important for initiation and maintenance of light-induced sleep during the dark phase.

OPN4 Protein Profile

Protein Summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with Opsin 4 Proteins (OPN4)

  • opsin 4.1 (opn4.1)
  • opsin 4 (OPN4)
  • opsin 4 (melanopsin) (opn4-A)
  • opsin 4a (melanopsin) (opn4a)
  • opsin 4 (Opn4)
  • opsin 4 (melanopsin) (Opn4)
  • 1110007J02Rik protein
  • cOpn4L protein
  • Gm533 protein
  • melanopsin protein
  • MOP protein
  • opn4 protein
  • OPN4-2 protein
  • opn4-A protein
  • opn4d protein
  • opn4l protein
  • opn4m2 protein
  • Xmop protein

Protein level used designations for Opsin 4 Proteins (OPN4)

melanopsin opn4m2 , melanopsin-like , opn4c , opsin 4 (melanopsin) , opsin 4, like , melanopsin , melanopsin 2 , opsin 4 like , putative Opsin 4 , opsin 4 , putative photopigment melanopsin , mammalian-like melanopsin , melanopsin opn4m1 , melanopsin-A , melanopsin-M , opn4m1 , opsin-4-A , opsin-4M , opsin-4

352918 Danio rerio
423609 Gallus gallus
515152 Bos taurus
611027 Canis lupus familiaris
735531 Pan troglodytes
100303707 Meleagris gallopavo
373689 Xenopus laevis
571624 Danio rerio
192223 Rattus norvegicus
94233 Homo sapiens
493921 Felis catus
30044 Mus musculus
Selected quality suppliers for OPN4 Proteins (OPN4)
Did you look for something else?