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Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. Additionally we are shipping Orexin A Antibodies (60) and Orexin A Kits (47) and many more products for this protein.
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Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin/hypocretin networks have been discovered.
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency
observation that inhibition of the Orexin-1 receptor signaling blunted binge-like Ethanol, and saccharin drinking suggests that reward-related Orexin circuits participate in the consumption of salient reinforcers regardless of calories.
Results suggest that exercise produces antidepressant effects via suppression of Hcrt/Orx and melanin-concentrating hormone (show PMCH Proteins) neural systems in the basolateral amygdala
Hcrt neuronal activity and Hcrt-mediated stress responses were inhibited by the satiety hormone leptin (show LEP Proteins).
This study demonstrated that the GABAergic input property of orexin neurons responds rapidly to sleep deprivation.
sleep deprivation or increasing wakefulness by rescue of orexinergic neurons in APP/PS1 mice lacking orexin increased the amount of amyloid beta pathology in the brain.
orexin activates the mTOR (show FRAP1 Proteins) pathway, a central regulator of cell growth and metabolism, in the mouse brain and cell lines that express GPCRs, OX1R (show HCRTR1 Proteins), or OX2R (show CD200R1 Proteins)
This study demonistrated that absence of the Hcrt peptide has gender-specific effects. In contrast, Hcrt-ataxin mice and human narcoleptics, with loss of the whole Hcrt cell, show weight gain in both sexes.
These results suggest that orexin neuronal activity plays a crucial role in the maintenance of wakefulness especially in the active phase in mice.
The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
first evidence for the expression of oxA and ox1R (show HCRTR1 Proteins) in the vestibular glands of mammalian genital tract
The impact of the phase of the estrous cycle on the observed changes in plasma orexin levels in domestic pigs.
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
, orexin A
, orexin B
, Hypocretin (orexin) neuropeptide