You are viewing an incomplete version of our website. Please click to reload the website as full version.

Organic Solute Transporter beta Proteins (OSTBETA)

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Additionally we are shipping Organic Solute Transporter beta Antibodies (14) and Organic Solute Transporter beta Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat OSTBETA OSTBETA 300790  
OSTBETA 123264 Q86UW2
OSTBETA 330962 Q80WK2
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Organic Solute Transporter beta Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Yeast REACT_Little Skate His tag   1 mg Log in to see 56 to 66 Days
$2,002.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

OSTBETA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Mouse (Murine)

More Proteins for Organic Solute Transporter beta (OSTBETA) Interaction Partners

Human Organic Solute Transporter beta (OSTBETA) interaction partners

  1. Hepatic OSTalpha (show OSTALPHA Proteins)-OSTbeta expression is induced by hypoxia.

  2. OSTbeta is a target of RARalpha (show RARA Proteins)-mediated (by binding to DR5 (show TNFRSF10B Proteins) response element) gene regulation pathways

  3. Ostbeta is required for both proper trafficking of Ostalpha (show OSTALPHA Proteins) and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes.

  4. The present report summarizes the evidence for a pleiotropic role of Ostalpha (show OSTALPHA Proteins)-Ostbeta in different tissues.

  5. OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (show SULT2A1 Proteins) homeostasis

  6. OSTbeta has roles in biological transport and is widely expressed in human tissues

  7. overexpr (show OSTALPHA Proteins)ession of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (show NR1H4 Proteins) and the activation of FXR target genes

  8. OSTalpha (show OSTALPHA Proteins)/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST (show DDOST Proteins) genes by the nuclear bile acid receptor (show NR1H4 Proteins)/farnesoid X receptor (show xpr1 Proteins) (FXR (show NR1H4 Proteins)).

  9. the selective localization of OSTalpha (show OSTALPHA Proteins) and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

  10. These results indicate that expression of Ostalpha (show OSTALPHA Proteins) and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (show NR1H4 Proteins).

Mouse (Murine) Organic Solute Transporter beta (OSTBETA) interaction partners

  1. Co-expression of mouse Ostalpha (show OSTALPHA Proteins)-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate

  2. OSTalpha (show OSTALPHA Proteins) and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (show NR1H4 Proteins)-/-, mice

  3. the selective localization of OSTalpha (show OSTALPHA Proteins) and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

  4. In conclusion, we identified Ost-alpha (show OSTALPHA Proteins)/Ost-beta as a novel FXR (show NR1H4 Proteins) target. Absent Ost-alpha (show OSTALPHA Proteins)/Ost-beta induction in CA-fed FXR (show NR1H4 Proteins)(-/-) animals may contribute to increased liver injury in these animals.

  5. The mouse Ostalpha (show OSTALPHA Proteins) and Ostbeta promoters are unusual in that they contain functional FXR (show NR1H4 Proteins) and LRH elements, which mediate, respectively, positive and negative feedback regulation by bile acids.

  6. These results indicate that expression of Ostalpha (show OSTALPHA Proteins) and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (show NR1H4 Proteins).

  7. LXRalpha (show NR1H3 Proteins) transcriptionally regulate mouse organic solute transporter alpha (show OSTALPHA Proteins)/beta via inverted repeat-1 elements shared with farnesoid X receptor (show xpr1 Proteins)

  8. Present as heterodimers (with Ost alpha (show OSTALPHA Proteins)) and/or heteromultimers; the interaction between Ostalpha (show OSTALPHA Proteins) and Ostbeta increases the stability of the proteins and is required for delivery of the heteromeric complex to the plasma membrane.

  9. These data indicate that Ostalpha (show OSTALPHA Proteins)-Ostbeta is essential for intestinal bile acid transport in mice.

  10. These findings provide direct support for the hypothesis that Ostalpha (show OSTALPHA Proteins)-Ostbeta is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver.

Organic Solute Transporter beta (OSTBETA) Protein Profile

Protein Summary

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).

Gene names and symbols associated with OSTBETA

  • solute carrier family 51, beta subunit (Slc51b)
  • organic solute transporter beta (SLC51B)
  • solute carrier family 51, beta subunit (SLC51B)
  • OSTB protein
  • OSTBETA protein
  • RGD1565748 protein

Protein level used designations for OSTBETA

organic solute transporter beta , OST-beta , organic solute transporter subunit beta , solute carrier family 51 subunit beta , organic solute transporter beta subunit , Ost beta

GENE ID SPECIES
300790 Rattus norvegicus
507185 Bos taurus
123264 Homo sapiens
330962 Mus musculus
Selected quality suppliers for Organic Solute Transporter beta Proteins (OSTBETA)
Did you look for something else?