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anti-Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) Antibodies

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Additionally we are shipping Origin Recognition Complex, Subunit 1-Like (Yeast) Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ORC1L 4998 Q13415
ORC1L 18392 Q9Z1N2
ORC1L 313479 Q80Z32
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Top anti-Origin Recognition Complex, Subunit 1-Like (Yeast) Antibodies at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rat Un-conjugated IP, WB 50 μL Log in to see 5 to 6 Days
$402.29
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated WB   0.1 mg Log in to see 5 to 7 Days
$341.25
Details
Human Rabbit Un-conjugated WB Western blot analysis of ORC1 expression in HeLa (A), MCF7 (B), PC12 (C), Ramos (D) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$522.50
Details
Human Mouse Un-conjugated ELISA 100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$375.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 8 to 10 Days
$478.50
Details

ORC1L Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Origin Recognition Complex, Subunit 1-Like (Yeast) Antibodies

  1. Human Monoclonal ORC1L Primary Antibody for WB - ABIN151050 : Toone, Aerne, Morgan, Johnston: Getting started: regulating the initiation of DNA replication in yeast. in Annual review of microbiology 1997 (PubMed)
    Show all 4 references for ABIN151050

  2. Human Polyclonal ORC1L Primary Antibody for ELISA, WB - ABIN1450965 : Gavin, Hidaka, Stillman: Conserved initiator proteins in eukaryotes. in Science (New York, N.Y.) 1996 (PubMed)
    Show all 2 references for ABIN1450965

  3. Human Monoclonal ORC1L Primary Antibody for IP, WB - ABIN108601 : Schepers, Ritzi, Bousset, Kremmer, Yates, Harwood, Diffley, Hammerschmidt: Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus. in The EMBO journal 2001 (PubMed)

More Antibodies against Origin Recognition Complex, Subunit 1-Like (Yeast) Interaction Partners

Fruit Fly (Drosophila melanogaster) Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. analyses show that orc1 allele newly identified is female sterile and possesses a unique feature of phenotypes that are distinct in different modes of DNA replication

  2. Orc1 functioned in silencing before duplication and Orc1 and Sir2 (show SIRT1 Antibodies) may have an ancient history of cooperating to generate chromatin structures, with Sir2 (show SIRT1 Antibodies) deacetylating histones and Orc1 binding to these deacetylated nucleosomes

Human Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. Orc1 acts as a nucleating center for origin recognition complex assembly and then pre-replication complex assembly by binding to mitotic chromosomes, followed by gradual removal from chromatin during the G1 phase.

  2. ORC1 harbors a G-rich RNA/ssDNA-binding domain, which may be involved in the preferential binding to G-quadruplex-formable RNA/DNA by ORC. Structure modeling predicts the structural similarity between the G-rich RNA/ssDNA-binding domain of ORC1 and part of mammalian DNA methyltransferase 1 (show DNMT1 Antibodies).

  3. ORC1 associated with transcription start sites of coding or noncoding RNAs. Transcription levels at the ORC1 sites directly correlated with replication timing.

  4. results identify the BAH (show ASPH Antibodies) domain as a novel methyl-lysine-binding module, thereby establishing the first direct link between histone methylation and the metazoan DNA replication machinery, and defining a pivotal aetiological role for the canonical H4K20me2 mark, via ORC1, in primordial dwarfism

  5. Orc1 harbors a PACT (show RBBP6 Antibodies) centrosome-targeting domain and a separate domain that differentially inhibits the protein kinase (show CDK7 Antibodies) activities of Cyclin E (show CCNE1 Antibodies)-CDK2 (show CDK2 Antibodies) and Cyclin A (show CCNA2 Antibodies)-CDK2 (show CDK2 Antibodies)

  6. Data show that purified Epstein-Barr nuclear antigen 1 EBNA1 (show EBNA-1 Antibodies) recruits purified Human Orc1 and Cdc6 (show CDC6 Antibodies) onto replication origin oriP.

  7. A lethal phenotype was seen in four individuals with compound heterozygous ORC1 mutations

  8. As cells moved through the cell cycle, the local-ization of ORC1 shifted, suggesting changes in thelocalization of ORC-bound origin sequences.

  9. Mutations in ORC1, encoding a subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. These mutations disrupt ORC1 functions including pre-replicative complex formation and origin activation.

  10. Data show that Orc1 specifically binds hypo-phosphorylated Rb and that this interaction is competitive with the binding of Rb to E2F1 (show E2F1 Antibodies).

Mouse (Murine) Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. mouse Orc1, Orc2, and Orc3 (show ORC3 Antibodies) each exist in two alternative-splicing variants and naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation

Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) Antigen Profile

Protein Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ORC1L

  • Origin recognition complex subunit 1 (Orc1) antibody
  • origin recognition complex subunit 1 (LOC100689425) antibody
  • origin recognition complex, subunit 1 (ORC1) antibody
  • origin recognition complex, subunit 1 (orc1) antibody
  • origin recognition complex, subunit 1 (Orc1) antibody
  • AA545195 antibody
  • CG10667 antibody
  • Dmel\\CG10667 antibody
  • DmOrc1 antibody
  • DmOrc1p antibody
  • dORC1 antibody
  • HSORC1 antibody
  • MmORC1 antibody
  • ORC antibody
  • orc1 antibody
  • Orc1l antibody
  • PARC1 antibody
  • rDmORC antibody
  • xorc1 antibody

Protein level used designations for ORC1L

CG10667-PA , Orc1-PA , origin recognition complex 1 , origin recognition complex subunit 1 , origin recognition complex, subunit 1 homolog , replication control protein 1 , origin recognition complex protein 1 , origin recognition complex, subunit 1-like

GENE ID SPECIES
35686 Drosophila melanogaster
100689425 Cricetulus griseus
4998 Homo sapiens
398063 Xenopus laevis
513523 Bos taurus
18392 Mus musculus
313479 Rattus norvegicus
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