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Outer Dense Fiber of Sperm Tails 2 Proteins (ODF2)

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. Additionally we are shipping ODF2 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ODF2 4957 Q5BJF6
ODF2 18286 A3KGV1
Rat ODF2 ODF2 29479 Q6AYX5
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Top ODF2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,249.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ODF2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Outer Dense Fiber of Sperm Tails 2 (ODF2) Interaction Partners

Human Outer Dense Fiber of Sperm Tails 2 (ODF2) interaction partners

  1. Cby (show CBY1 Proteins) plays an important role in organization of both primary and motile cilia in collaboration with Cnx (show CANX Proteins).

  2. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.

  3. Cdk5 (show CDK5 Proteins) in the centriolar appendages mediates cenexin1 localization and primary cilia formation (show PIFO Proteins).

  4. Mouse and rat ODF2 (show ODF1 Proteins) protein homolog sequences and expression are compared.

  5. We propose that hCenexin1 is a critical centrosomal component whose C-terminal extension is required for proper recruitment of Plk1 and other components crucial for normal mitosis.

  6. A splice variant of hODF2 called hCenexin1, but not hODF2 itself, efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits Plk1 through a Cdc2 (show CDK1 Proteins)-dependent phospho-S796 motif within the extension.

Mouse (Murine) Outer Dense Fiber of Sperm Tails 2 (ODF2) interaction partners

  1. Pax6 (show PAX6 Proteins) directly regulates the activity of the Odf2 gene encoding for the appendage-specific protein Odf2 with a role for the assembly of mother centriole.

  2. The presence of multiple splicing variants hints that the function of Odf2 is diversified in such a way that each variant has a distinct role in the complex cellular and developmental processes.

  3. In adult mice, Odf2 expression was marked in the interdental cells, Boettcher cells, the root cells and root cell processes. Fainter expression was also visible in the hair cells of the maculae and cristae

  4. C-terminal region of Odf2 in mice is sufficient for ciliogenesis, the resulting basal bodies lack basal feet; loss of basal feet in ciliated epithelia disrupts polarized organization of apical microtubule lattice without affecting planar cell polarity.

  5. Results document the possible impact of loss of one Odf2 allele on sperm tail structure and function, resulting in a novel sperm tail phenotype.

  6. Odf2 contributes to assorted ciliopathies

  7. Odf2 is indispensable for the formation of distal/subdistal appendages and the generation of primary cilia, but not for other cell-cycle-related centriolar functions.

  8. Knockout of the abundant sperm tail protein (show SPAG4 Proteins), outer dense fiber 2, results in preimplantation lethality.

  9. ODF2 is the main isoform in testicular tissue RT-PCR analyses revealed that isoforms are not restricted to specific tissues

  10. findings show that testicular expression of Odf2 correlates with spermiogenesis and ongoing sperm tail formation thus implicating functional differences between ODF2 and Cenexin.

ODF2 Protein Profile

Protein Summary

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers.

Gene names and symbols associated with ODF2

  • outer dense fiber of sperm tails 2 (ODF2)
  • outer dense fiber of sperm tails 2 (odf2)
  • outer dense fiber of sperm tails 2 (Odf2)
  • AI848335 protein
  • CT134 protein
  • DKFZp469J0214 protein
  • MMTEST29 protein
  • ODF2/1 protein
  • ODF2/2 protein
  • ODF84 protein
  • si:dkey-228b2.4 protein

Protein level used designations for ODF2

outer dense fiber of sperm tails 2 , outer dense fiber protein 2 , cenexin , outer dense fiber of sperm tails protein 2 , cancer/testis antigen 134 , cenexin 1 , outer dense fiber of sperm tails, 84-kD , sperm tail structural protein , 84 kDa outer dense fiber protein , outer dense fiber of sperm tail 2 , sperm outer dense fiber major protein 2 , testis-specific autoantigen

GENE ID SPECIES
100070205 Equus caballus
100125786 Xenopus (Silurana) tropicalis
100173182 Pongo abelii
4957 Homo sapiens
792921 Danio rerio
496006 Xenopus laevis
417213 Gallus gallus
491315 Canis lupus familiaris
100156735 Sus scrofa
539043 Bos taurus
18286 Mus musculus
29479 Rattus norvegicus
464769 Pan troglodytes
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