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OSBPL5 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Additionally we are shipping Oxysterol Binding Protein-Like 5 Antibodies (23) and many more products for this protein.
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imprinting status of four cattle genes (Tssc4 (show TSSC4 Proteins),Nap1l4 (show NAP1L4 Proteins), Phlda2 (show PHLDA2 Proteins) and Osbpl5) in seven types of tissues, were assessed in cattle.
ORP5/8 are endoplasmic reticulum (ER) membrane proteins implicated in lipid trafficking that localize to ER-plasma membrane (PM) contacts and maintain membrane homeostasis. Here the authors show that PtdIns(4,5)P 2 plays a critical role in the targeting and function of ORP5/8 at the PM.
mammalian ORP5 and ORP8 (show OSBPL8 Proteins) proteins localize to ER-mitochondrial MCS (show SMCP Proteins), in addition to ER-PM contact sites.
Results show that OSBPL5 and CALU (show CALU Proteins) were expressed at higher levels in the lung tissues of metastasis-positive cases than that in the metastasis-negative cases suggesting they can promote invasiveness of lung cancer cells.
ORP5 and ORP8 (show OSBPL8 Proteins) could mediate PI4P/phosphatidylserine (PS) countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM), thus delivering PI4P to the ER-localized PI4P phosphatase Sac1 (show SACM1L Proteins) for degradation and PS from the ER to the PM.
ORP5 may cooperate with NPC1 (show NPC1 Proteins) to mediate the exit of cholesterol from endosomes/lysosomes.
OBPH1/Obph1 gene is imprinted, with preferential expression from the maternal allele in human and mouse.
Telomeric NAP1L4 (show NAP1L4 Proteins) and OSBPL5 of the KCNQ1 (show KCNQ1 Proteins) cluster, and the DECORIN (show DCN Proteins) gene are not imprinted in human trophoblast stem cells.
OSBPL5 is relatd to invasion and poor prognosis in pancreatic cancer.
OSBP (show OSBP Proteins) regulates hepatic TG metabolism and suggest the involvement of OSBP (show OSBP Proteins) in the insulin (show INS Proteins) signaling pathways that control hepatic lipogenesis.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified.
oxysterol binding protein-like 5
, oxysterol-binding protein-related protein 5-like
, OSBP-related protein 5
, oxysterol-binding protein homolog 1
, oxysterol-binding protein homologue 1
, oxysterol-binding protein-related protein 5
, oxysterol binding protein 2
, oxysterol binding protein homolog 1
, oxysterol-binding protein-like protein 5