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PITPNM3 encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. Additionally we are shipping PITPNM Family Member 3 Proteins (3) and many more products for this protein.
Showing 10 out of 34 products:
Human Polyclonal PITPNM3 Primary Antibody for IHC (p), IHC - ABIN268542
Lev, Hernandez, Martinez, Chen, Plowman, Schlessinger: Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. in Molecular and cellular biology 1999
Human Polyclonal PITPNM3 Primary Antibody for ICC, IF - ABIN441109
Su, Liao, Liu, Huang, He, Chen, Yang, Wu, Chen, Lin, Zeng, Ouyang, Cui, Yao, Su, Huang, Lieberman, Liu, Song: Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer. in Cell research 2017
CCL18 can increase the invasive ability of non-small cell lung cancer cells by binding to its receptor Nir1.
CCL18 (show CCL18 Antibodies) enhances hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cell migration, invasion, and epithelial-mesenchymal transition (EMT (show ITK Antibodies)) through the expression of PITPNM3 and the activation of the NF-kappaB (show NFKB1 Antibodies) signaling pathway.
Data indicate that PYK2 N-terminal domain interacting receptor 1 (Nir1) could induce epithelial-mesenchymal transition by stabilising Snail (show SNAI1 Antibodies) via the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/GSK3beta (show GSK3b Antibodies)/Snail (show SNAI1 Antibodies) signalling pathway through binding to CCL18 (show CCL18 Antibodies).
Our observations of the PITPNM3 p.Q626H mutation carriers confirm that CORD5 (show GUCY2D Antibodies) is a disease not to mix with other retinal degenerations mapped to 17p13.
CCL18 (show CCL18 Antibodies) derived from Tumor-associated macrophages (TAMs) lays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.
Thus, mutations in PITPNM3 do not appear to be a major cause of cone or cone-rod dystrophy.
Our finding on the first mutation in the human homologue of Drosophila rdgB (show PITPNM1 Antibodies) indicates novel pathways and a potential important role of the PITPNM3 in mammalian phototransduction.
Mutation in the PYK2 (show PTK2B Antibodies)-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5 (show GUCY2D Antibodies)) in two Swedish families.
This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
, PITPnm 3
, PYK2 N-terminal domain-interacting receptor 1
, atypical chemokine receptor 6
, cone rod dystrophy 5
, membrane-associated phosphatidylinositol transfer protein 3
, phosphatidylinositol transfer protein, membrane-associated 3
, retinal degeneration B alpha 3
, pyk2 N-terminal domain-interacting receptor 1