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POU5F1 encodes a transcription factor containing a POU homeodomain. Additionally we are shipping OCT4 Kits (53) and OCT4 Proteins (17) and many more products for this protein.
Showing 10 out of 348 products:
Human Polyclonal OCT4 Primary Antibody for EIA, IHC (p) - ABIN357429
Looijenga, Stoop, de Leeuw, de Gouveia Brazao, Gillis, van Roozendaal, van Zoelen, Weber, Wolffenbuttel, van Dekken, Honecker, Bokemeyer, Perlman, Schneider, Kononen, Sauter, Oosterhuis: POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. in Cancer research 2003
Show all 5 references for ABIN357429
Human Polyclonal OCT4 Primary Antibody for EIA, IF - ABIN357427
Reményi, Lins, Nissen, Reinbold, Schöler, Wilmanns: Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. in Genes & development 2003
Show all 5 references for ABIN357427
Human Polyclonal OCT4 Primary Antibody for IHC (p), WB - ABIN655493
Abu-Remaileh, Gerson, Farago, Nathan, Alkalay, Zins Rousso, Gur, Fainsod, Bergman: Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling. in The EMBO journal 2010
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Chimpanzee Polyclonal OCT4 Primary Antibody for EIA, WB - ABIN401448
Cauffman, Van de Velde, Liebaers, Van Steirteghem: Oct-4 mRNA and protein expression during human preimplantation development. in Molecular human reproduction 2005
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Human Polyclonal OCT4 Primary Antibody for IF, WB - ABIN388789
Crouau-Roy, Amadou, Bouissou, Clayton, Vernet, Ribouchon, Pontarotti: Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping. in Genomics 1994
Show all 4 references for ABIN388789
Human Polyclonal OCT4 Primary Antibody for IF, WB - ABIN388788
Takeda, Seino, Bell: Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. in Nucleic acids research 1992
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Cow (Bovine) Polyclonal OCT4 Primary Antibody for WB - ABIN2792671
Suo, Han, Wang, Zhang, Zhao, Zhao, Dai: Oct4 pseudogenes are transcribed in cancers. in Biochemical and biophysical research communications 2005
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Human Polyclonal OCT4 Primary Antibody for WB - ABIN783318
Pan, Thomson: Nanog and transcriptional networks in embryonic stem cell pluripotency. in Cell research 2007
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Human Polyclonal OCT4 Primary Antibody for ELISA, WB - ABIN185438
Jones, Ulbright, Eble, Baldridge, Cheng: OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. in The American journal of surgical pathology 2004
Show all 2 references for ABIN185438
Cow (Bovine) Polyclonal OCT4 Primary Antibody for WB - ABIN2778604
Palma, Peña, Contreras, Ceballos-Reyes, Coyote, Eraña, Kofman-Alfaro, Queipo: Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation. in Cancer letters 2008
Oct4 plays a pivotal role in the maintenance of lung CSCs resistant to gefitinib in EGFR (show EGFR Antibodies) mutation-positive non-small cell lung cancer
the efficacy and reliability in utilizing Oct4 to isolate and characterize liver tumor propagating cells, is reported.
The promoter activity of Nanog (show NANOG Antibodies) and Oct4 were upregulated, and beta-catenin (show CTNNB1 Antibodies) was observed to bind to these promoters during H. pylori infection, while a Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) inhibitor suppressed promoter activity and binding.
Higher OCT4 expression represents a clinically relevant predictor of patient prognosis in prostate cancer
the results demonstrated for the first time that OCT4B1 functions as an oncogene (show RAB1A Antibodies) in colon cancer and provides the development of novel therapeutic strategies to treat colon cancer, particularly drug resistance
Low-frequency functional variant in POU5F1 may contribute to the risk of congenital heart malformations.
Sox2 (show SOX2 Antibodies) and Oct4 function as molecular rheostats and utilize negative feedback loops to carefully balance their expression and other critical genes during embryogenesis. (Review)
Knockdown of OCT4 during differentiation inhibits mesendoderm formation and removal of the H3K27me3 mark from the SOX17 (show SOX17 Antibodies) promoter, suggesting that OCT4 acts to induce removal of the Polycomb2 complex.
OCT4A induction following DNA damage in PA-1 (show PAGR1 Antibodies) cells, performs a cell stress, rather than self-renewal, function by moderating the expression of p21Cip1 (show CDKN1A Antibodies), which alongside AMPK (show PRKAA1 Antibodies) helps to then regulate autophagy.
In hepatocellular carcinoma cells, OCT4 overexpression promoted cancer stem-like phenotypes.
showed novel molecular regulation of CDX2 (show CDX2 Antibodies) on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 (show CDX2 Antibodies) and Oct4 in embryo of mammals other than mouse
Overexpression of Sox2 (show SOX2 Antibodies) or Oct4 in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Antibodies) results in higher proliferation and differentiation compared to controls.
Oct4 positive stem/progenitor swine lung epithelial cells are targets for influenza virus replication.
study shows that localization of octamer-binding protein 4(OCT4) is associated with an embryonic stem cell (ESC)-like morphology from porcine inner cell mass
OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level.
in the forming endoderm at the primitive streak stage, OCT4 was detectable in potential primordial germ cells only; in the ectoderm and mesodermal cell lineages OCT4 was cleared at the neural groove and somite stage, respectively
we concluded that OCT4 expression in somatic cells is not a good prognosis marker for selecting cell lines.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Oct4 exhibited significant hypermethylation in sperm compared with that in oocytes
In contrast to protein distribution, regulation of Oct4 transcription is conserved between mammalian species.
analysis of CpG islands of bovine Leptin (show LEP Antibodies) and POU5F1 genes in cloned bovine fetuses
The restoration of pluripotency can be directly observed in living cells or SCNT embryos from such Pou5f1-EGFP transgenic fetuses.
sequences of mRNA and translated protein of the newly identified genes and those of POU5F1 were aligned to their mammalian orthologs to determine the degree of evolutionary conservation
Higher values of OCT-4 expression were observed in embryos and endometrial tissue in females reproduced under heat conditions.
protein expression during rabbit embryonic development: investigation of temporal and spatial relationship of expression of Oct-4, Cdx-2 (caudal type homeobox transcription factor 2 (show CDX2 Antibodies)) and histone H4 (acetylated at lysine 5) in morula/blastocysts
The signal may have reflected the regulation of Oct-4 through enhancer switching and therefore may be related to cell lineage formation in rabbit embryos.
The POU5F1 gene is strictly regulated during early embryo development.
Cytoplasmic CD44 (show CD44 Antibodies) and absence of nuclear Oct3/4 suggest that the cells of cardiac sarcomas may represent 'daughter' stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation.
Lack of restricted OCT4 protein, and inner cell mass localization of NANOG in primate blastocysts, suggests that NANOG may determine inner cell mass fate more specifically during primate development.
OCT4-SOX2 (show SOX2 Antibodies) configuration that dimerizes on a Hoxb1 (show HOXB1 Antibodies)-like composite, a canonical element with juxtaposed individual binding sites, plays a more critical role in the induction and maintenance of pluripotency.
The long noncoding RNA Gm15055 is highly expressed in mouse embryonic stem cells and its expression is maintained by OCT4.
The Oct4 distal enhancer interacts with genomic loci that exhibit open chromosome features and contain active histone marks.
In summary, the data presented here reveal that TRIM32 (show TRIM32 Antibodies) directly regulates at least two of the four Yamanaka Factors (cMyc (show MYC Antibodies) and Oct4), to modulate cell fate transitions.
Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.
Pluripotency transcription factors Nanog (show NANOG Antibodies) and Oct4 positively modulate Sod2 (show SOD2 Antibodies) gene transcription in induced pluripotent stem cells.
Results suggest that Oct4 and Sox 2 (show SOX2 Antibodies) transcription factors can decrease nucleosome occupancy in vivo at poised genes, but do not alter in vivo nucleosome occupancy at active genes.
YAP1 (show YAP1 Antibodies) regulates OCT4 activity and SOX2 (show SOX2 Antibodies) expression to facilitate self-renewal of stem-like cell
findings demonstrate that chromatin organization and transcriptional programs are intimately connected in ESCs (show NR2E3 Antibodies) and that the dynamic positioning of the Oct4 alleles is associated with the transition from pluripotency to lineage specification.
The BET family member BRD4 (show BRD4 Antibodies) interacts with OCT4 and regulates pluripotency gene expression
Regulation of mych by Pou5f1 appears to be direct transcriptional activation.
The posttranslational modification by phosphorylation opens the possibility that Pou5f1 may be subject to temporal or region specific modulation of its activity or stability by embryonic signaling mechanisms.
discuss mechanistic implications of simultaneous activation of transcriptional targets by ubiquitous, like Pou5f1, and region-specific inducers, emerging as a common regulatory motif in early development
maternal Nanog (show NANOG Antibodies), Pou5f1 and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (show MYLIP Antibodies)-430 expression
thses data position Pou5f1 and SOX (show PIPOX Antibodies)-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control.
The defects due to HEP induction were rescued by introducing wild-type pou2 mRNA before the heat treatments.
Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system.
Pou2 functions in multiple aspects of vertebrate development, especially in the binary decision of the mesendoderm to mesoderm and endoderm in different ways depending on the developmental stage.
show that Pou5f1 binds to phylogenetically conserved Oct (show Plxna2 Antibodies)/Pou5f1 sites in the vox promoter, both in vivo and in vitro
The temporospatial structure of the zebrafish Pou5f1 target networks may explain aspects of the evolution of the mammalian stem cell networks.
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6\;22)(p21\;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
POU class 5 homeobox 1
, POU domain, class 5, transcription factor 1-like
, POU domain class 5 transcription factor 1
, POU domain, class 5, transcription factor 1
, POU domain transcription factor OCT4
, POU-type homeodomain-containing DNA-binding protein
, octamer-binding protein 3
, octamer-binding protein 4
, octamer-binding transcription factor 3
, octamer-binding transcription factor-3
, Octamer-binding transcription factor 3
, octamer binding transcription factor 4
, POU domain gene 2
, spiel ohne grenzen
, spiel ohne grenzen/pou2