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Paired Immunoglobin-Like Type 2 Receptor alpha Proteins (PILRA)

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. Additionally we are shipping PILRA Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PILRA 29992 Q9UKJ1
PILRA 231805 Q2YFS3
Rat PILRA PILRA 288568  
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Top PILRA Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

PILRA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) , ,
,

Top referenced PILRA Proteins

  1. Human PILRA Protein expressed in Human Cells - ABIN2005906 : Mousseau, Banville, LAbbé, Bouchard, Shen: PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN2005906

  2. Mouse (Murine) PILRA Protein expressed in Human Cells - ABIN2007549 : Fournier, Chalus, Durand, Garcia, Pin, Churakova, Patel, Zlot, Gorman, Zurawski, Abrams, Bates, Garrone: FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. in Journal of immunology (Baltimore, Md. : 1950) 2000 (PubMed)
    Show all 2 references for ABIN2007549

More Proteins for Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) Interaction Partners

Human Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) interaction partners

  1. PILRalpha exhibits large conformational change to recognize simultaneously both the sTn (show EEF1A2 Proteins) O-glycan and the compact peptide structure constrained by proline residues

  2. These results contribute our knowledge of the biological functions of HBVDNAPTP1 and provide novel data to aid in the further analysis of the regulatory mechanism of this protein.

  3. The authors show that the human ocular and highly neurovirulent HSV-1 strain McKrae enters substantially more efficiently into cells via the gB-specific human paired immunoglobulin-like type-2 receptor-alpha (hPILR-alpha).

  4. Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).

  5. These results suggest that PANP (show C12orf53 Proteins) is involved in immune regulation as a ligand of the PILRalpha.

  6. Insertional mutations of gB reduced cell fusion activity when PILRalpha was overexpressed much more than nectin-1 (show PVRL1 Proteins).

Mouse (Murine) Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA) interaction partners

  1. demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp (show C12orf53 Proteins) and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation

  2. Data indicate paired Ig-like type 2 receptor (PILR)alpha Pilra-/- mice develop enhanced autoimmune arthritis.

  3. Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).

  4. These results suggest that PANP (show C12orf53 Proteins) is involved in immune regulation as a ligand of the PILRalpha.

  5. Activation of PILRa or deletion of PILRb (show PILRB Proteins) helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response.

PILRA Protein Profile

Protein Summary

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Gene names and symbols associated with PILRA

  • paired immunoglobin-like type 2 receptor alpha (PILRA)
  • paired immunoglobin-like type 2 receptor alpha (Pilra)
  • AV021745 protein
  • FDF03 protein
  • PILRA protein
  • RGD1562847 protein

Protein level used designations for PILRA

paired immunoglobulin-like type 2 receptor alpha , paired immunoglobin-like type 2 receptor alpha , cell surface receptor FDF03 , inhibitory receptor PILR-alpha

GENE ID SPECIES
463597 Pan troglodytes
489841 Canis lupus familiaris
100137734 Bos taurus
29992 Homo sapiens
231805 Mus musculus
288568 Rattus norvegicus
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