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PALM encodes a member of the paralemmin protein family. Additionally we are shipping Paralemmin Antibodies (29) and Paralemmin Kits (9) and many more products for this protein.
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Paralemmin-1 is expressed in normal and tumor-derived lymphatic endothelial cells. It represses cell migration and delays the formation of tube-like lymphatic structures by modulating cell adhesion, filopodia formation and plasma membrane blebbing.
Expression of Palm in the mouse striatum is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase (show COMT Proteins)).
report that palmitoylation-deficient (Palm(-/-)) mice carrying two Cys to Thr and Ser mutations in the opsin gene displayed profound light-induced retinal degeneration that first involved rod and then cone cells.
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.