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Paraoxonase 1 Proteins (PON1)

The enzyme encoded by PON1 is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Additionally we are shipping Paraoxonase 1 Antibodies (167) and Paraoxonase 1 Kits (59) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PON1 5444 P27169
PON1 18979 P52430
PON1 84024 P55159
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Top Paraoxonase 1 Proteins at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$795.30
Details
HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
$341.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,977.33
Details
HOST_Human Human His tag 10 μg Log in to see 6 to 11 Days
$323.38
Details

PON1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Paraoxonase 1 (PON1) Interaction Partners

Human Paraoxonase 1 (PON1) interaction partners

  1. PON1 polymorphism might be one of the genetic factors of longevity in the Bama Zhuang population.

  2. First study in the literature to show an association between paraoxonase-1 activity and thyroid hormone (show PTH Proteins) concentration and neural tube defects.

  3. Apo A (show APOA Proteins)-I and paraoxonase-1 levels may be clinically useful for ischemic stroke diagnosis and for differentiating between ischemic and hemorrhagic strokes.

  4. PON1 overexpression protects against AAA (show APP Proteins) progression by reducing oxidative stress, apoptosis and inflammation

  5. FGF-23 (show FGF23 Proteins) and PON1 lactonase have roles in native AV fistula thrombosis in hemodialysis patients

  6. The analysis of this study shows a significant contribution of the rs662 variant of Pon1 to ischemic stroke risk

  7. The R allele of the Q192R variant in the paraoxonase-1 gene is dose-dependently related to the severity of left ventricular hypertrophy and left ventricular dysfunction and associates with the longitudinal evolution of these cardiac alterations.

  8. The most significant finding of this study is AA allele activity which is low in BC cases was found high. We concluded that decreased AA allele PON1 activity might have a relation with BC

  9. PON1 activity was lower in Alzheimer's disease patients than controls. There was a negative correlation between PON1 activity and carotid plaque in the overall study group.

  10. study demonstrated that the genetic risk for heart diseases is associated with the PON1 gene polymorphisms. L55M polymorphism is a risk factor and Q192R polymorphism is protective in certain populations. It is worth noting that the 192Q allele may be a risk factor to develop coronary artery disease

Mouse (Murine) Paraoxonase 1 (PON1) interaction partners

  1. PON1 overexpression protects against AAA (show AAAS Proteins) progression by reducing oxidative stress, apoptosis and inflammation

  2. Paraoxonase 1 (PON1) influence circadian gene expression and period length

  3. results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL (show HSD11B1 Proteins), owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.

  4. Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.

  5. 5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.

  6. HDL (show HSD11B1 Proteins) (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages.

  7. Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis

  8. The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats.

  9. PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis.

  10. PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina.

Pig (Porcine) Paraoxonase 1 (PON1) interaction partners

  1. PON1 behaves as a negative acute phase protein (show ORM1 Proteins) in pigs since a significant decrease (P<0.05) in its activity after 72 h of the induction of the inflammation was observed with all substrates.

Cow (Bovine) Paraoxonase 1 (PON1) interaction partners

  1. characterization the SNPs in the promoter region of the bovine PON1 gene, and to evaluation of association with serum PON1 activity in periparturient Holstein cows

  2. The results suggest that PON1 might be a better parameter for minimal redox state changes in serum, shortly after labour in the examined breeds.

  3. Data indicate that Cu(2+), Mn(2+), Zn(2+), Ni(2 (show VMP1 Proteins)+), and Pb(2+) were found to inhibite the paraoxonase 1 (PON1) enzyme activity in a concentration-dependent fashion.

  4. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.

  5. Significantly lower PON1 activity and PON1/high density lipoprotein ratio in lactating cows compared to heifers showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress.

  6. The activity of PON1 and malondialdehyde in late pregnancy and early lactation in dairy cattle is reported.

Rabbit Paraoxonase 1 (PON1) interaction partners

  1. ApoE (show APOE Proteins) mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL (show HSD11B1 Proteins) paraoxonase activity

  2. PON1 can decrease the AChE inhibition, and alleviated clinical signs and tissue damage caused by dichlorvos.

Paraoxonase 1 (PON1) Protein Profile

Protein Summary

The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Gene names and symbols associated with Paraoxonase 1 Proteins (PON1)

  • paraoxonase 1 (pon1)
  • paraoxonase 1 (PON1)
  • paraoxonase 1 (Pon1)
  • ESA protein
  • MGC53915 protein
  • MGC89222 protein
  • MVCD5 protein
  • Pon protein
  • PON1 protein
  • pon2 protein

Protein level used designations for Paraoxonase 1 Proteins (PON1)

paraoxonase 1 , paraoxonase 2 , serum paraoxonase/arylesterase 1-like , A-esterase 1 , K-45 , PON 1 , aromatic esterase 1 , arylesterase B-type , esterase A , paraoxonase B-type , serum aryldiakylphosphatase , serum aryldialkylphosphatase 1 , serum paraoxonase/arylesterase 1 , serum paraoxonase

GENE ID SPECIES
448598 Xenopus (Silurana) tropicalis
463547 Pan troglodytes
699355 Macaca mulatta
100408915 Callithrix jacchus
100436640 Pongo abelii
100602768 Nomascus leucogenys
5444 Homo sapiens
18979 Mus musculus
84024 Rattus norvegicus
475234 Canis lupus familiaris
100048952 Sus scrofa
523798 Bos taurus
100009133 Oryctolagus cuniculus
100721268 Cavia porcellus
101116983 Ovis aries
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