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Paraoxonase 2 Proteins (PON2)

PON2 encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. Additionally we are shipping PON2 Antibodies (103) and PON2 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PON2 5445 Q15165
PON2 330260 Q62086
Rat PON2 PON2 296851 Q6AXM8
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Top PON2 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
HOST_Human Human His tag 10 μg Log in to see 6 to 11 Days
$355.71
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,706.64
Details
HOST_Human Human His tag   10 μg Log in to see 6 to 11 Days
$355.71
Details
HOST_Escherichia coli (E. coli) Please inquire Un-conjugated   10 μg Log in to see 5 to 6 Days
$169.03
Details

PON2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for Paraoxonase 2 (PON2) Interaction Partners

Human Paraoxonase 2 (PON2) interaction partners

  1. PON2 SNPs rs12026 and rs7493 were associated with intracerebral hemorrhage. The C alleles of rs12026 and rs7493 contributed to a decreased risk of ICH (show COL4a2 Proteins).

  2. Data indicate the relationship between ubiqutination of lysine (Lys (show LYZ Proteins)) 168 and paraoxonase 2 (PON2) catalytic activity.

  3. Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1 (show PON1 Proteins), PON2, PON3 (show PON3 Proteins)) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL (show HSD11B1 Proteins) level in blood. [REVIEW]

  4. Haplotype containing two risk alleles of PON1 (show PON1 Proteins) and PON2 genes was significantly associated with disease diabetes mellitus, type 2.

  5. D1-like receptors inhibit ROS (show ROS1 Proteins) production by altering PON2 distribution in membrane microdomains in the short-term, and by increasing PON2 expression in the long-term.

  6. PON2 is a central regulator of host cell responses to Pseudomonas aeruginosa N-(3-oxo-dodecanoyl)-L-homoserine lactone

  7. PON2 levels reflect the cells' irradiation sensitivity.

  8. Newborns with PON2 148AG/GG genotype and exposed to high concentrations of MBP (show MBL2 Proteins) and MEHP had higher risks of LBW and SBL

  9. A modest dose-dependent allele effect between the PON2 c.311C > G polymorphism, increased triglyceride concentrations and decreased LDL particle size distribution.

  10. Taken together, our data suggest a model by which DJ-1 (show PARK7 Proteins) exerts its antioxidant activities, at least partly through regulation of PON2.

Mouse (Murine) Paraoxonase 2 (PON2) interaction partners

  1. PON2 plays an important role in innate immune defense against Pseudomonas aeruginosa infection.

  2. macrophage triglyceride accumulation upregulates PON2 expression via MEK (show MDK Proteins)/ JNK/c-Jun pathway, and these effects could be related, at least in part, to cellular triglycerides-induced ROS (show ROS1 Proteins) formation.

  3. These results suggest that PON2 is a novel major intracellular factor that protects CNS cells against oxidative stress and confers gender-dependent susceptibility to such stress

  4. Macrophage PON2 modulates mechanisms that link endoplasmic reticulum stress, mitochondrial dysfunction and the development of atherosclerosis.

  5. results demonstrate that PON2 plays an important role in hepatic insulin (show INS Proteins) signalling and underscores the influence of macrophage-mediated inflammatory response on hepatic insulin (show INS Proteins) sensitivity.

  6. Results illustrate that the antiatherogenic effects of PON2 are, in part, mediated by the role of PON2 in mitochondrial function.

  7. Under normal conditions macrophage endoplasmic reticulum stabilizes PON2 activity, and this effect could be attributed to ER proteins and redox status.

  8. PON2 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.

  9. Pomegranite juice consumption antioxidative properties on mouse macrophages are mediated via PJ-induced stimulation of macrophage PON2 expression.

  10. analysis of macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice

Pig (Porcine) Paraoxonase 2 (PON2) interaction partners

  1. The expression of the PON2 gene was greater in Meishan pig than that in Yorkshire on gestational day 26 and 90.

Cow (Bovine) Paraoxonase 2 (PON2) interaction partners

  1. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (show PON1 Proteins), 2 and 3 in granulosa cells and PON1 (show PON1 Proteins) activity in follicular fluid and plasma of dairy cows.

PON2 Protein Profile

Protein Summary

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with Paraoxonase 2 Proteins (PON2)

  • paraoxonase 2 (PON2)
  • paraoxonase 2 (LOC100218152)
  • paraoxonase 2 (LOC100340152)
  • Serum paraoxonase/arylesterase 2 (pon1)
  • serum paraoxonase/arylesterase 2 (BDBG_00600)
  • Serum paraoxonase/arylesterase 2 (pon2)
  • paraoxonase 2 (Pon2)
  • 6330405I24Rik protein
  • AI481612 protein
  • MGC53915 protein
  • pon1 protein
  • pon2 protein

Protein level used designations for Paraoxonase 2 Proteins (PON2)

A-esterase 2 , Aromatic esterase 2 , PON 2 , Serum aryldialkylphosphatase 2 , Serum paraoxonase/arylesterase 2 , paraoxonase 2 , celiac disease 2 , serum paraoxonase/arylesterase 2-like , serum paraoxonase/arylesterase 2 , aromatic esterase 2 , paraoxonase nirs , serum aryldialkylphosphatase 2

GENE ID SPECIES
100303695 Meleagris gallopavo
463549 Pan troglodytes
100145861 Ovis aries
100218152 Taeniopygia guttata
100340152 Oryctolagus cuniculus
100407939 Callithrix jacchus
380341 Xenopus laevis
8507698 Ajellomyces dermatitidis SLH14081
100196477 Salmo salar
5445 Homo sapiens
330260 Mus musculus
296851 Rattus norvegicus
403855 Canis lupus familiaris
100142663 Sus scrofa
281417 Bos taurus
395830 Gallus gallus
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