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Paraspeckle Component 1 Proteins (PSPC1)

PSPC1 encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. Additionally we are shipping Paraspeckle Component 1 Antibodies (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PSPC1 55269 Q8WXF1
Rat PSPC1 PSPC1 305910 Q4KLH4
PSPC1 66645 Q8R326
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Top Paraspeckle Component 1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PSPC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Paraspeckle Component 1 (PSPC1) Interaction Partners

Human Paraspeckle Component 1 (PSPC1) interaction partners

  1. The crystal structure of the heterodimer of the multidomain conserved region of the Drosophila behavior/human splicing proteins, PSPC1 and NONO (show NONO Proteins), is described.

  2. downregulated were the a protein coding gene PSPC1 in breast and ovarian cancer cells

  3. crystal of PSPC1-NONO (show NONO Proteins) contained one heterodimer in the asymmetric unit and diffracted to 1.9 A resolution using synchrotron radiation

  4. We map the domain within PSP1 that is mediating this interaction and show it is required for the correct localization of PSP1 to paraspeckles. This interaction is necessary but not sufficient for paraspeckle targeting by PSP1

Mouse (Murine) Paraspeckle Component 1 (PSPC1) interaction partners

  1. Specific interaction with the nuclear transporter (show RPAIN Proteins) importin (show KPNA4 Proteins) alpha2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles.

  2. NONO genetic insufficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ.

  3. A protein complex was identified containing PSPC1, PSF (show Il3 Proteins) and LMX1B (show LMX1B Proteins), suggesting the existence of this complex in mesodiencephalic dopaminergic neurons.

  4. mPSP1 may regulate multiple phases of important nuclear events during spermatogenesis.

  5. PSPC1, NONO (show NONO Proteins), and SFPQ form complexes with each other in Sertoli cells and may regulate androgen receptor (show AR Proteins)-mediated transcriptional activity

Paraspeckle Component 1 (PSPC1) Protein Profile

Protein Summary

This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.

Gene names and symbols associated with PSPC1

  • paraspeckle component 1 (PSPC1)
  • paraspeckle component 1 (Tsp_01792)
  • paraspeckle component 1 (pspc1)
  • paraspeckle component 1 (LOC100221455)
  • paraspeckle component 1 (Pspc1)
  • paraspeckle protein 1 (Pspc1)
  • 5730470C09Rik protein
  • AI327109 protein
  • AI449052 protein
  • fj85a06 protein
  • PSP1 protein
  • rexp86 protein
  • wu:fj85a06 protein
  • zgc:136470 protein

Protein level used designations for PSPC1

paraspeckle component 1 , paraspeckle protein 1 , mPSP1

GENE ID SPECIES
452452 Pan troglodytes
477347 Canis lupus familiaris
705080 Macaca mulatta
10912093 Trichinella spiralis
100023187 Monodelphis domestica
100101798 Xenopus (Silurana) tropicalis
100195503 Salmo salar
100221455 Taeniopygia guttata
100381037 Xenopus laevis
100408755 Callithrix jacchus
100520511 Sus scrofa
100588134 Nomascus leucogenys
55269 Homo sapiens
305910 Rattus norvegicus
506696 Bos taurus
418955 Gallus gallus
692285 Danio rerio
66645 Mus musculus
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