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anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Antibodies

The precise function of PARK2 is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Additionally we are shipping Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) Kits (23) and Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PARK2 50873 Q9WVS6
PARK2 56816 Q9JK66
PARK2 5071 O60260
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Top anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) Antibodies at antibodies-online.com

Showing 10 out of 191 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of anti-PARK2 (Parkin) Antibody (N-term) (ABIN39... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB The anti-Parkin C-term Pab (ABIN390366) is used in Western blot to det... Formalin-fixed and paraffin-embedded human cancer tissue reacted with ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB (LEFT)Formalin-fixed and paraffin-embedded human cancer tissue reacted... The anti-Parkin C-term Pab is used in Western blot to detect Parkin in... 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-PARK2 (Parkin) Antibody (N-term) in NCI-... 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to PARK2 on HeLa cell (antib... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Cow Rabbit Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Park2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:... WB Suggested Anti-Park2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: ... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-Parki... Formalin-fixed and paraffin embedded rat testis labeled with Anti-Park... 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human skeletal musc... 100 μg Log in to see 2 to 3 Days
$275.00
Details

PARK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) Antibodies

  1. Human Polyclonal PARK2 Primary Antibody for EIA, IHC (p) - ABIN358990 : Kumru, Santamaria, Tolosa, Valldeoriola, Muñoz, Marti, Iranzo: Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations. in Annals of neurology 2004 (PubMed)
    Show all 5 references for ABIN358990

  2. Human Monoclonal PARK2 Primary Antibody for IF, WB - ABIN393540 : Kägi, Klein, Wood, Schneider, Pramstaller, Tadic, Quinn, van de Warrenburg, Bhatia: Nonmotor symptoms in Parkin gene-related parkinsonism. in Movement disorders : official journal of the Movement Disorder Society 2010 (PubMed)
    Show all 5 references for ABIN393540

  3. Human Polyclonal PARK2 Primary Antibody for FACS, IF - ABIN390366 : West, Kapatos, OFarrell, Gonzalez-de-Chavez, Chiu, Farrer, Maidment: N-myc regulates parkin expression. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN390366

  4. Human Polyclonal PARK2 Primary Antibody for FACS, IF - ABIN390365 : Wang, Denison, Lai, Philips, Montoya, Kock, Schüle, Klein, Shridhar, Roberts, Smith: Parkin gene alterations in hepatocellular carcinoma. in Genes, chromosomes & cancer 2004 (PubMed)
    Show all 2 references for ABIN390365

  5. Human Polyclonal PARK2 Primary Antibody for EIA, WB - ABIN358989 : Pigullo, De Luca, Barone, Marchese, Bellone, Colosimo, Scaglione, Martinelli, Di Maria, Pizzuti, Abbruzzese, Dallapiccola, Ajmar, Mandich: Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor. in Parkinsonism & related disorders 2004 (PubMed)
    Show all 2 references for ABIN358989

  6. Human Polyclonal PARK2 Primary Antibody for IF (p), IHC (p) - ABIN735578 : Li, Zhang, Wang, Liu, Yang, Liu, Lu: Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant ?-synuclein. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 (PubMed)

  7. Human Polyclonal PARK2 Primary Antibody for WB - ABIN372698 : Jenner, Dexter, Sian, Schapira, Marsden: Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group. in Annals of neurology 1992 (PubMed)

More Antibodies against Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) Interaction Partners

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. We demonstrate here that vps35 (show vps35 Antibodies) genetically interacts with parkin

  2. Clu (show CLU Antibodies) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1 (show PINK1 Antibodies)-Park pathway of mitochondrial quality control.

  3. Human Mask homolog ANKHD1 (show ANKHD1 Antibodies) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1 (show PINK1 Antibodies)/parkin mutations.

  4. These results indicate that the in vivo rescue is due to restoring CI activity rather than promoting mitophagy Our findings support the emerging view that PINK1 (show PINK1 Antibodies) plays a role in regulating CI activity separate from its role with Parkin in mitophagy

  5. MUL1 (show MUL1 Antibodies) acts in parallel to the PINK1 (show PINK1 Antibodies)/parkin pathway on a shared target mitofusin (show MFN2 Antibodies) to maintain mitochondrial integrity.

  6. Parkin cooperates with PINK1 to promote hnRNP-F/Glo ubiquitination and nRCC mRNA translation.

  7. The loss-of-function mutation in parkin results in defective immune response against bacterial infection. Additionally, parkin mutant larvae showed hypersensitivity against wound regardless of bacterial infection.

  8. data thus support the potential of folic acid in alleviating the behavioural defects, oxidative stress, augmentation of zinc and ATP levels in parkin knock down flies

  9. Parkin phosphorylation by PINK1 (show PINK1 Antibodies) drives Parkin E3 activity. endogenous PINK1 (show PINK1 Antibodies) precisely controls Parkin activity to maintain the mitochondrial function in muscle tissue and the neuronal function in dopaminergic neurons.

  10. Our findings thus suggest that Lon (show LONP1 Antibodies) plays an essential role in regulating the PINK1 (show PINK1 Antibodies)-Parkin pathway by promoting the degradation of PINK1 (show PINK1 Antibodies) in the matrix of healthy mitochondria

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. In mouse hearts Parkin functions as a stress-induced and developmentally-programmed facilitator of cardiomyocyte mitochondrial turnover. (Review)

  2. findings support the notion that BAG2 (show BAG2 Antibodies) is an upstream regulator of the PINK1 (show PINK1 Antibodies)/PARKIN signaling pathway.

  3. The PINK1 (show PINK1 Antibodies)-Parkin pathway is activated in response to metabolic stress

  4. Overexpressed human wild type alpha-synuclein (show SNCA Antibodies) in the substantia nigra was phosphorylated at Ser (show SIGLEC1 Antibodies) 129 significantly more in parkin knockout mice, though the total alpha synuclein (show SNCA Antibodies) levels were the same as in wild type mice.

  5. analysis of two types of mitophagy, a DNM1L (show DNM1L Antibodies)-dependent pathway and a PARK2-dependent pathway

  6. FBXW8 (show FBXW8 Antibodies) and PARK2 are sequestrated into insolubility by ATXN2 (show ATXN2 Antibodies) PolyQ expansions, but only FBXW8 (show FBXW8 Antibodies) expression is dysregulated

  7. PARK2 function where damaged mitochondria are targeted for degradation via a PARK2/PINK1 (show PINK1 Antibodies)-mediated mechanism.

  8. instead of transcriptional reprogramming, fetal cardiomyocyte mitochondria undergo perinatal Parkin-mediated mitophagy and replacement by mature adult mitochondria. Mitophagic mitochondrial removal underlies developmental cardiomyocyte mitochondrial plasticity and metabolic transitioning of perinatal hearts.

  9. the dysregulation of Parkin-PARIS-PGC-1alpha (show PPARGC1A Antibodies) pathway by metabolic malregulation may contribute to the pathogenesis of Parkinson's disease and metformin might exert a neuroprotective effect on Parkinson's disease via the restoration of parkin

  10. Data indicates that Parkin regulates mitotic progression and its deficiency results in multiple mitotic defects, genomic instability, and tumorigenesis suggesting a role as tumor suppressor.

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. UBL domain specifically interacts with the R1 domain and negatively regulates Parkin E3 ligase activity.

  2. A recent report, solving the structure of a Parkin-phosphoubiquitin complex, greatly advances the understanding of the Parkin activation mechanism.

  3. Study shows that heterozygous carriers of copy number variants affecting exons of PARK2 have greater risk of Parkinson's disease than non-carriers.

  4. A role was established for Parkin in regulating the endo-lysomal pathway.

  5. pathogenic PINK1 (show PINK1 Antibodies) mutants which are not cleaved by PARL (show PARL Antibodies) affect PINK1 (show PINK1 Antibodies) kinase activity and the ability to induce PARK2-mediated mitophagy.

  6. Maintenance of appropriate mitochondrial HSD17B10 (show HSD17B10 Antibodies) levels is one of mechanisms by which PARK2 preserves mitochondrial quality. The loss of this protective mechanism may contribute to mitochondrial dysfunction and neuronal degeneration in Parkinson Disease

  7. Epistatic SNP-SNP interactions involving PARK2 and cytokine genes provide an additive risk towards leprosy susceptibility.

  8. study reports that ubiquitinPhospho-Ser65 can prime Parkin to be efficiently phosphorylated by PINK1 (show PINK1 Antibodies) at Ser65 of its Ubl domain, which in turn leads to maximal activation of Parkin E3 ligase activity

  9. results are consistent with increased iron load in LRRK2 (show LRRK2 Antibodies)- and Parkin-mutation carriers. The increased R2* in asymptomatic PD-mutation carriers suggests that iron deposition occurs early during the preclinical phase of the disease

  10. Differential expression of parkin in multiple system atrophy brains was found compared to control and Parkinson's disease brains.

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Antigen Profile

Protein Summary

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Gene names and symbols associated with PARK2

  • parkin (park) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2) antibody
  • parkin (CpipJ_CPIJ014867) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (LOC100150461) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (Park2) antibody
  • AR-JP antibody
  • CG10523 antibody
  • Dmel\\CG10523 antibody
  • Dpark antibody
  • dpk antibody
  • LOC100150461 antibody
  • LPRS2 antibody
  • Park antibody
  • PDJ antibody
  • pdr-1 antibody
  • Prkn antibody
  • SD01679 antibody
  • si:ch211-123f21.1 antibody
  • zgc:112390 antibody

Protein level used designations for PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkin protein , parkin variant SV5DEL , parkinson juvenile disease protein 2

GENE ID SPECIES
40336 Drosophila melanogaster
550328 Danio rerio
741350 Pan troglodytes
6049109 Culex quinquefasciatus
100150461 Danio rerio
50873 Mus musculus
56816 Rattus norvegicus
5071 Homo sapiens
612316 Canis lupus familiaris
733673 Sus scrofa
100724550 Cavia porcellus
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