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PARK2 antibody (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin)) (AA 111-140)

Details for Product anti-PARK2 Antibody No. ABIN390365, Supplier: Log in to see
Antigen
  • AR-JP
  • CG10523
  • Dmel\\CG10523
  • Dpark
  • dpk
  • LOC100150461
  • LPRS2
  • Park
  • PDJ
  • pdr-1
  • Prkn
  • PRKN
  • SD01679
  • si:ch211-123f21.1
  • zgc:112390
Epitope
AA 111-140, N-Term
25
24
24
18
9
5
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
190
47
39
10
6
3
3
2
2
1
1
Host
Rabbit
163
22
11
Clonality (Clone)
Polyclonal ()
Conjugate
This PARK2 antibody is un-conjugated
6
5
5
3
3
3
3
3
3
3
3
3
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
147
69
54
33
29
24
12
11
10
2
2
1
1
1
Supplier
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Immunogen This Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 AA from the N-terminal region of human Parkin.
Clone RB7371
Isotype Ig
Specificity This Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118~148 amino acids from the N-terminal region of human Park2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Parkin (PARK2 Antibody Abstract)
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.
Synonyms: Parkin isoform 1, Parkin, E3 ubiquitin ligase, Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, PRKN, Park2
Molecular Weight 51651 DA
Gene ID 5071
NCBI Accession NP_004553
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50, IF = 1:10-50, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-PARK2 antibody (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin)) (AA 111-140) (ABIN390365) Western blot analysis of anti-PARK2 (Parkin) Antibody (N-term) (ABIN390365) in NCI-H4...
Background publications West, Kapatos, OFarrell, Gonzalez-de-Chavez, Chiu, Farrer, Maidment: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004

Wang, Denison, Lai, Philips, Montoya, Kock, Schüle, Klein, Shridhar, Roberts, Smith: "Parkin gene alterations in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 40, Issue 2, pp. 85-96, 2004