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Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) Proteins (PARK2)

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Additionally we are shipping PARK2 Antibodies (204) and PARK2 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PARK2 50873 Q9WVS6
PARK2 56816 Q9JK66
PARK2 5071 O60260
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Top PARK2 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,309.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details

PARK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

More Proteins for Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. We demonstrate here that vps35 (show vps35 Proteins) genetically interacts with parkin

  2. Clu (show CLU Proteins) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1 (show PINK1 Proteins)-Park pathway of mitochondrial quality control.

  3. Human Mask homolog ANKHD1 (show ANKHD1 Proteins) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1 (show PINK1 Proteins)/parkin mutations.

  4. These results indicate that the in vivo rescue is due to restoring CI activity rather than promoting mitophagy Our findings support the emerging view that PINK1 (show PINK1 Proteins) plays a role in regulating CI activity separate from its role with Parkin in mitophagy

  5. MUL1 (show MUL1 Proteins) acts in parallel to the PINK1 (show PINK1 Proteins)/parkin pathway on a shared target mitofusin (show MFN2 Proteins) to maintain mitochondrial integrity.

  6. Parkin cooperates with PINK1 to promote hnRNP-F/Glo ubiquitination and nRCC mRNA translation.

  7. The loss-of-function mutation in parkin results in defective immune response against bacterial infection. Additionally, parkin mutant larvae showed hypersensitivity against wound regardless of bacterial infection.

  8. data thus support the potential of folic acid in alleviating the behavioural defects, oxidative stress, augmentation of zinc and ATP levels in parkin knock down flies

  9. Parkin phosphorylation by PINK1 (show PINK1 Proteins) drives Parkin E3 activity. endogenous PINK1 (show PINK1 Proteins) precisely controls Parkin activity to maintain the mitochondrial function in muscle tissue and the neuronal function in dopaminergic neurons.

  10. Our findings thus suggest that Lon (show LONP1 Proteins) plays an essential role in regulating the PINK1 (show PINK1 Proteins)-Parkin pathway by promoting the degradation of PINK1 (show PINK1 Proteins) in the matrix of healthy mitochondria

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. p62 (show GTF2H1 Proteins) are subjected to parkin mediated proteasomal degradation

  2. A comprehensive analysis of influence of the Parkinson disease-associated genes Parkin and DJ-1 (show PARK7 Proteins) on neurotransmitter receptor (show GRIN1 Proteins) expression in mice

  3. Whereas Parkin has been reported to positively regulate the expression of OPA1 through NEMO (show IKBKG Proteins), herein we found that PARK2 overexpression did not modify the expression of OPA1.

  4. In mouse hearts Parkin functions as a stress-induced and developmentally-programmed facilitator of cardiomyocyte mitochondrial turnover. (Review)

  5. findings support the notion that BAG2 (show BAG2 Proteins) is an upstream regulator of the PINK1 (show PINK1 Proteins)/PARKIN signaling pathway.

  6. The PINK1 (show PINK1 Proteins)-Parkin pathway is activated in response to metabolic stress

  7. Overexpressed human wild type alpha-synuclein in the substantia nigra was phosphorylated at Ser 129 significantly more in parkin knockout mice, though the total alpha synuclein levels were the same as in wild type mice.

  8. analysis of two types of mitophagy, a DNM1L (show DNM1L Proteins)-dependent pathway and a PARK2-dependent pathway

  9. FBXW8 (show FBXW8 Proteins) and PARK2 are sequestrated into insolubility by ATXN2 (show ATXN2 Proteins) PolyQ expansions, but only FBXW8 (show FBXW8 Proteins) expression is dysregulated

  10. PARK2 function where damaged mitochondria are targeted for degradation via a PARK2/PINK1 (show PINK1 Proteins)-mediated mechanism.

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Fibroblasts isolated from skin biopsy specimens from patients with genetic forms of Parkinson's disease, carriers of mutations in LRRK2 (show LRRK2 Proteins) and PARK2 genes, and from a healthy volunteer were reprogrammed into induced pluripotent stem cells.

  2. PARK2 mutant neuroprogenitors show increased cytotoxicity with copper (Cu) and cadmium (Cd) exposure, and a substantial increase in mitochondrial fragmentation, initial ROS (show ROS1 Proteins) generation, and loss of mitochondrial membrane potential following Cu exposure.

  3. These studies provide valuable insight into the roles, and cellular hierarchy, of distinct phosphorylation events in parkin activation, and profiles mutations in Parkinson's patients.

  4. UBL domain specifically interacts with the R1 domain and negatively regulates Parkin E3 ligase activity.

  5. A recent report, solving the structure of a Parkin-phosphoubiquitin complex, greatly advances the understanding of the Parkin activation mechanism.

  6. Study shows that heterozygous carriers of copy number variants affecting exons of PARK2 have greater risk of Parkinson's disease than non-carriers.

  7. A role was established for Parkin in regulating the endo-lysomal pathway.

  8. pathogenic PINK1 (show PINK1 Proteins) mutants which are not cleaved by PARL (show PARL Proteins) affect PINK1 (show PINK1 Proteins) kinase activity and the ability to induce PARK2-mediated mitophagy.

  9. Maintenance of appropriate mitochondrial HSD17B10 (show HSD17B10 Proteins) levels is one of mechanisms by which PARK2 preserves mitochondrial quality. The loss of this protective mechanism may contribute to mitochondrial dysfunction and neuronal degeneration in Parkinson Disease

  10. Epistatic SNP-SNP interactions involving PARK2 and cytokine genes provide an additive risk towards leprosy susceptibility.

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

PARK2 Protein Profile

Protein Summary

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Gene names and symbols associated with PARK2

  • parkin (park)
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (park2)
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2)
  • parkin (CpipJ_CPIJ014867)
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (LOC100150461)
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2)
  • parkinson protein 2, E3 ubiquitin protein ligase (Park2)
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (Park2)
  • AR-JP protein
  • CG10523 protein
  • Dmel\\CG10523 protein
  • Dpark protein
  • dpk protein
  • LOC100150461 protein
  • LPRS2 protein
  • Park protein
  • PDJ protein
  • pdr-1 protein
  • Prkn protein
  • SD01679 protein
  • si:ch211-123f21.1 protein
  • zgc:112390 protein

Protein level used designations for PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkin protein , parkin variant SV5DEL , parkinson juvenile disease protein 2

GENE ID SPECIES
40336 Drosophila melanogaster
550328 Danio rerio
741350 Pan troglodytes
6049109 Culex quinquefasciatus
100150461 Danio rerio
50873 Mus musculus
56816 Rattus norvegicus
5071 Homo sapiens
612316 Canis lupus familiaris
733673 Sus scrofa
100724550 Cavia porcellus
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