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Patatin-Like phospholipase Domain Containing 3 Proteins (PNPLA3)

The protein encoded by PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. Additionally we are shipping PNPLA3 Antibodies (90) and PNPLA3 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PNPLA3 80339 Q9NST1
PNPLA3 116939 Q91WW7
PNPLA3 362972  
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Top PNPLA3 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PNPLA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced PNPLA3 Proteins

  1. Human PNPLA3 Protein expressed in Wheat germ - ABIN1315587 : Winberg, Motlagh, Stenkula, Holm, Jones: Adiponutrin: a multimeric plasma protein. in Biochemical and biophysical research communications 2014 (PubMed)

More Proteins for Patatin-Like phospholipase Domain Containing 3 (PNPLA3) Interaction Partners

Human Patatin-Like phospholipase Domain Containing 3 (PNPLA3) interaction partners

  1. transmembrane 6 superfamily 2 C/T or T/T variants in conjunction with patatin-like phospho-lipase (show LIPG Proteins) domain-containing protein 3 (show HSPB3 Proteins) G/G variants may be potential genetic risk factors for developing HCC (show FAM126A Proteins) in alcohol-related cirrhosis.

  2. Steatosis severity was independently associated with PNPLA3 rs738409 in large cohort of patients with genotype 1 Chronic hepatitis C.

  3. I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing Nonalcoholic fatty liver disease.

  4. PNPLA3 148M Carriers with Inflammatory Bowel Diseases Have Higher Susceptibility to Hepatic Steatosis and Higher Liver Enzymes.

  5. PNPLA3 rs738409 polymorphism was associated with the severity of liver fibrosis in patients coinfected with HIV and hepatitis C virus.

  6. Letter: PNPLA3 I148M affects de novo NAFLD occurrence with a prominent interaction with obesity in liver transplant recipients.

  7. PNPLA3 polymorphism is associated with Hepatocellular Carcinoma Development in Non-Viral Chronic Liver Diseases.

  8. This study investigates the association between PNPLA3 rs738409 with health services utilization in a general population. PNPLA3 rs738409 was associated with the number of outpatient visits, hospitalization, and inpatient days.

  9. Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: effect of Omacor administration.

  10. As the HepG2 cell line harbors the I148M mutation in homozygous state it is hypothesized that this should represent an ideal model system for PNPLA3 biology.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 3 (PNPLA3) interaction partners

  1. Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.

  2. PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake

  3. adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids

  4. data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.

  5. Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin (show INS Proteins) resistance in mice.

  6. Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1 (show ME1 Proteins), SPOT14 (show THRSP Proteins), and SCD1 (show SCD Proteins).

  7. data suggest that murine ATGL (show PNPLA2 Proteins) but not adiponutrin contributes to net adipocyte lipolysis and that ATGL (show PNPLA2 Proteins) and adiponutrin are oppositely regulated by insulin (show INS Proteins) both in vitro and in vivo

PNPLA3 Protein Profile

Protein Summary

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.

Gene names and symbols associated with PNPLA3

  • patatin-like phospholipase domain containing 3 (PNPLA3)
  • patatin-like phospholipase domain containing 3 (Pnpla3)
  • Adpn protein
  • C22orf20 protein
  • iPLA(2)epsilon protein

Protein level used designations for PNPLA3

acylglycerol O-acyltransferase , adiponutrin , calcium-independent phospholipase A2-epsilon , iPLA2-epsilon , iPLA2epsilon , patatin-like phospholipase domain-containing protein 3

GENE ID SPECIES
80339 Homo sapiens
116939 Mus musculus
362972 Rattus norvegicus
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