anti-Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Antibodies

PNPLA2 encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Additionally we are shipping Patatin-Like phospholipase Domain Containing 2 Kits (37) and Patatin-Like phospholipase Domain Containing 2 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PNPLA2 57104 Q96AD5
PNPLA2 66853 Q8BJ56
PNPLA2 361676 P0C548
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Top anti-Patatin-Like phospholipase Domain Containing 2 Antibodies at antibodies-online.com

Showing 10 out of 179 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, IHC, IHC (fro), IHC (p), WB Western Blot: PEDF R/PNPLA2/ATGL Antibody (2G2) [NBP1-25852] - The extracts of mouse kidney (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human ATGL (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Immunohistochemistry-Paraffin: PEDF R/PNPLA2/ATGL Antibody (2G2) [NBP1-25852] - Human ATGL (1:25) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB). 0.1 mL Log in to see 7 to 9 Days
$381.94
Details
Human Rabbit Un-conjugated IP, IHC, WB Western blot analysis of ATGL expression in rat kidney tissue lysate. 100 μg Log in to see 2 to 3 Days
$245.00
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN190844 (0.5µg/ml) staining of Human Adipose lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Mouse Un-conjugated CyTOF, FACS, WB Detection of PEDF R/PNPLA2 in Y-79 Human Cell Line by Flow Cytometry. Y-79 human retinoblastoma cell line was stained with Mouse Anti-Human PEDF R/PNPLA2 Monoclonal Antibody. Detection of PEDF R/PNPLA2 in Y-79 Human Cell Line by Flow Cytometry. Y-79 human retinoblastoma cell line was stained with Mouse Anti-Human PEDF R/PNPLA2 Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$262.50
Details
Human Goat Un-conjugated IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: PEDF R/PNPLA2/ATGL Antibody [ABIN2529204] - Staining of Human Heart. Western Blot: PEDF R/PNPLA2/ATGL Antibody [ABIN2529204] - Staining of Human Adipose lysate. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Goat Un-conjugated ELISA, WB ABIN334463 (0.03µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Goat Un-conjugated ELISA, WB Western Blot: PEDF R/PNPLA2/ATGL Antibody [NBP1-00226] - Analysis of PEDF R/PNPLA2/ATGL in Human Heart lysate (35ug protein in RIPA buffer) using this antibody at 0.03ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Cow Goat Un-conjugated IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Cow Goat Un-conjugated IHC (p), ELISA Human Heart (formalin-fixed, paraffin-embedded) stained with PNPLA2 antibody ABIN337131 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details

PNPLA2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Patatin-Like phospholipase Domain Containing 2 Antibodies

  1. Polyclonal PNPLA2 Primary Antibody for WB - ABIN540337 : Haemmerle, Lass, Zimmermann, Gorkiewicz, Meyer, Rozman, Heldmaier, Maier, Theussl, Eder, Kratky, Wagner, Klingenspor, Hoefler, Zechner: Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. in Science (New York, N.Y.) 2006 (PubMed)

  2. Human Monoclonal PNPLA2 Primary Antibody for CyTOF, FACS - ABIN4899287 : He, Wu, Gong, Luo, Zhang, Li, Lu, Wei, Yang: Enhanced efficacy of combination therapy with adeno‑associated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma. in Molecular medicine reports 2014 (PubMed)

  3. Human Polyclonal PNPLA2 Primary Antibody for IHC (p), IHC - ABIN252920 : Schoenborn, Heid, Vollmert, Lingenhel, Adams, Hopkins, Illig, Zimmermann, Zechner, Hunt, Kronenberg: The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. in Diabetes 2006 (PubMed)

  4. Human Polyclonal PNPLA2 Primary Antibody for ELISA, WB - ABIN314328 : Steinberg, Kemp, Watt: Adipocyte triglyceride lipase expression in human obesity. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)

  5. Human Monoclonal PNPLA2 Primary Antibody for ELISA, IHC - ABIN449788 : Mason, Meex, Russell, Canny, Watt: Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise. in PLoS ONE 2014 (PubMed)

More Antibodies against Patatin-Like phospholipase Domain Containing 2 Interaction Partners

Goat Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. the ATGL gene plays an important role in triglyceride lipolysis in GMECs; ATGL may be involved in lipid metabolism during lactation

Human Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. Oxidative stress decreased the levels of PNPLA2 transcripts with no effect on ALOX5 (show ALOX5 Antibodies) expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 (show PTGR1 Antibodies) levels and death of RPE (show RPE Antibodies) cells undergoing oxidative stress.

  2. Results suggest that increased adipose triglyceride lipase (ATGL) expression is associated with increased adiposity and stromal proliferation in patients with pancreatic ductal adenocarcinoma (PDAC).

  3. A missense mutation in PNPLA2 is the rare cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease.

  4. A novel deletion was identified in PNPLA2 protein from a patient with complete deficiency of adipose triglyceride lipase.

  5. Rab32 (show RAB32 Antibodies) controls intracellular lipid accumulation through inducing lipolysis via enhancing ATGL expression indirectly.

  6. Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 (show G0S2 Antibodies) product (G0S2 (show G0S2 Antibodies)) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL).

  7. Authors show that rat ATGL, coactivated by rat CGI-58 (show ABHD5 Antibodies), efficiently hydrolyzes triglycerides and retinyl ester.

  8. PNPLA2 mutations were associated with an extended phenotype, including brain involvement in cases of neutral lipid-storage disease with myopathy.

  9. Distinct cardiac phenotype between two homozygotes born in a village with accumulation of a genetic deficiency of adipose triglyceride lipase.

  10. ANGPTL8 is a stress-response protein that down-regulates expression of ATGL.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. The Atgl is down-regulated by the basal transcription factor Sp1 (show SP1 Antibodies) in preadipocytes and that the magnitude of down-regulation depends on interactions between Sp1 (show SP1 Antibodies) and peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG Antibodies)).

  2. TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 (show DGAT1 Antibodies) inhibitor, T863. The lipase (show LIPG Antibodies) inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC (show FUT1 Antibodies)). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin (show ACTG2 Antibodies), in rat HSCs, but not in mouse HSCs.

  3. G0S2 (show G0S2 Antibodies) protein but not mRNA levels were reduced in the adipose tissue of ATGL-deficient mice, corroborating the involvement of ATGL in the stabilization of G0S2 (show G0S2 Antibodies)

  4. Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage.

  5. These data raise the possibility that ATGL deficiency could impair the renal fatty acid metabolism though inhibiting PPARalphaexpression, which may lead to lipid deposition and cell apoptosis of PCT (show UROD Antibodies), and finally contribute to the renal fibrosis and dysfunction

  6. Markers of mitochondrial content and respiration were increased in adipose tissue from ATGL knockout mice.

  7. ase (show ARSE Antibodies). Similar changes of GPNMB and G0S2 (show G0S2 Antibodies) expression were present in a human liposarcoma database. These results show that a previously-unknown, fully penetrant epistatic interaction between Pnpla2 and Lipe (show LIPE Antibodies) can cause liposarcoma in mice. DAKO mice provide a promising model for studying early premalignant changes that lead to late-onset malignant disease.

  8. Activities of adipose triglyceride lipase (ATGL), hormone sensitive lipolitic enzyme (HSL (show LIPE Antibodies)) and monoacylglycerol lipase (MGL (show MGLL Antibodies)) were significantly higher (51 %, 38 %, 49 %) in the DE group than the HF group (p < 0.05). MGL (show CLEC10A Antibodies), there were no differences between the CO group, HF group, and DC group, with the DE group (70 %) being significantly higher (p < 0.05).

  9. ATGL activity is required for UCP1 (show UCP1 Antibodies) activation in intact adipocytes. (Review)

  10. ATGL-dependent lipolysis plays a critical role in mediating diverse effects of FoxO (show FOXO3 Antibodies) proteins in the liver, including effects on gluconeogenic, glycolytic, and lipogenic gene expression and metabolism.

Pig (Porcine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. Results identified functional polymorphisms providing new evidence of PNPLA2 as an important candidate gene for fat deposition and carcass traits in pigs.

  2. Resveratrol activated sirtuin 1 (Sirt1 (show SIRT1 Antibodies)) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (show SIRT1 Antibodies) regulation pattern for PPARgamma (show PPARG Antibodies) to that of ATGL in adipocytes.

  3. analysis of porcine adipose triglyceride lipase (PNPLA2) gene

  4. JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies) and MAPK (show MAPK1 Antibodies) signaling pathways, as well as PPAR gamma (show PPARG Antibodies) all played important roles in the ATGL expression mediated by leptin (show LEP Antibodies)

  5. patatin-like phospholipase domain containing 2 gene (PNPLA2) is assiged to chromosome 2 in pigs.

  6. ATGL expression reacts to hormonal stimuli and plays a role in catecholamine-induced lipolysis in porcine adipose tissue.

Cow (Bovine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) interaction partners

  1. Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.

Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Antigen Profile

Protein Summary

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.

Gene names and symbols associated with PNPLA2

  • patatin-like phospholipase domain containing 3 (pnpla3) antibody
  • patatin-like phospholipase domain containing 2 (PNPLA2) antibody
  • patatin-like phospholipase domain containing 2 (pnpla2) antibody
  • adipose triglyceride lipase (ATGL) antibody
  • patatin-like phospholipase domain containing 2 (Pnpla2) antibody
  • 0610039C21Rik antibody
  • 1110001C14Rik antibody
  • Atgl antibody
  • iPLA2zeta antibody
  • PEDF-R antibody
  • pnpla2 antibody
  • RGD1309044 antibody
  • TTS-2.2 antibody
  • TTS2 antibody
  • zgc:92195 antibody

Protein level used designations for PNPLA2

patatin-like phospholipase domain-containing protein 2 , patatin-like phospholipase domain containing 2 , adipose triglyceride lipase , IPLA2-zeta , TTS2.2 , calcium-independent phospholipase A2 , desnutrin , patatin-like phospholipase domain containing protein 2 , pigment epithelium-derived factor , transport-secretion protein 2.2 , triglyceride hydrolase , transport-secretion protein , PNPLA2/ATGL

GENE ID SPECIES
436610 Danio rerio
611403 Canis lupus familiaris
780152 Xenopus (Silurana) tropicalis
100219060 Taeniopygia guttata
100294555 Meleagris gallopavo
100860889 Capra hircus
57104 Homo sapiens
66853 Mus musculus
100049704 Sus scrofa
508493 Bos taurus
431066 Gallus gallus
361676 Rattus norvegicus
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