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Paternally Expressed 10 Proteins (PEG10)

This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. Additionally we are shipping Paternally Expressed 10 Antibodies (94) and Paternally Expressed 10 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PEG10 23089 Q86TG7
PEG10 170676 Q7TN75
Rat PEG10 PEG10 678843  
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Top Paternally Expressed 10 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PEG10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Paternally Expressed 10 (PEG10) Interaction Partners

Human Paternally Expressed 10 (PEG10) interaction partners

  1. important role in trophoblast proliferation and promotes trophoblast invasion through TIMP-1 (show TIMP1 Proteins)

  2. Results revealed that PEG10 high expression was closely associated with the TNM (show ODZ1 Proteins) classification in lung cancer and is a critical indicator for poor prognosis. Also, It promotes significantly proliferation, migration and invasion of A549 lung cancer cells.

  3. The downregulated expression of the imprinted gene PEG10 may be an important reason for the occurrence of preeclampsia.

  4. elevated expression of PEG10 is likely to be involved in the pathophysiology of preeclampsia

  5. promotes migration of Burkitt's lymphoma cells via upregulation of matrix metalloproteinase-2 (show MMP2 Proteins) and -9

  6. Overexpression of PEG10 and TSG101 (show TSG101 Proteins) was detected in gallbladder adenocarcinoma.

  7. PEG10 imprinting is lost in a majority of hepatocellular carcinomas and no correlation exists between the imprinting status of PEG10 and its expression in HCC (show FAM126A Proteins) tissues.

  8. the mRNA expression level of PEG10 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts.

  9. In third trimester PEG10 was downregulated in fetal samples group

  10. PEG10 gene is imprinted, with preferential expression from the paternal allele.

Pig (Porcine) Paternally Expressed 10 (PEG10) interaction partners

  1. polymorphisms in PEG10 and PPP1R9A were associated with fat deposition and carcass traits

  2. The imprinting status of PEG10 is conserved in swine as paternal expression was demonstrated by quantitative allelic sequencing of reciprocal crosses in fetal tissues of whole brain, carcass, liver and placentae.

  3. The expression patterns of PLAGL1 (show PLAGL1 Proteins) and PEG10 genes in two breeds of swine are reported.

Cow (Bovine) Paternally Expressed 10 (PEG10) interaction partners

  1. the abnormal DNA methylation (show HELLS Proteins) epigenetic reprogramming of imprinting PEG10 gene in placenta may be one of the main causes of the abnormal development and death of the transgenic cloned cattle.

Mouse (Murine) Paternally Expressed 10 (PEG10) interaction partners

  1. Loss of DNA methylation (show HELLS Proteins) at the Peg10 imprinted gDMD associated with decreased embryonic viability and decreased labyrinthine volume.

  2. Knockdown of Syncytin-A (show ERVW-1 Proteins) demonstrated a functional regulation of cell-cell fusion, where knockdown of Peg10 showed no involvement in cell fusion

  3. Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes.

  4. Peg10 gene is imprinted, with preferential expression from the paternal allele, and its deletion results in early embryonic lethality.

  5. Results indicate that the induction of the imprinted gene paternally expressed 10 (PEG10) may play an important role during liver regeneration or carcinogenesis of the hepatocyte.

  6. These findings strongly indicate that peg10 plays a crucial role at the immediate early (show JUN Proteins) stage of adipocyte differentiation.

  7. the ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals

Paternally Expressed 10 (PEG10) Protein Profile

Protein Summary

This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.

Gene names and symbols associated with PEG10

  • paternally expressed 10 (PEG10)
  • paternally expressed 10 (Peg10)
  • AA407948 protein
  • Edr protein
  • HB-1 protein
  • Mar2 protein
  • Mart2 protein
  • MEF3L protein
  • MyEF-3 protein
  • RGAG3 protein

Protein level used designations for PEG10

paternally expressed 10 , MEF3 like 1 , MEF3-like protein 1 , embryonal carcinoma differentiation regulated , embryonal carcinoma differentiation-regulated protein , mammalian retrotransposon-derived protein 2 , myelin expression factor 3-like protein 1 , paternally expressed gene 10 protein , retrotransposon gag domain containing 3 , retrotransposon gag domain-containing protein 3 , retrotransposon-derived gag-like polyprotein , retrotransposon-derived protein PEG10 , ty3/Gypsy-like protein , MyEF-3 like , embryonal carcinoma differentiation regulated protein , myelin expression factor 3

GENE ID SPECIES
472446 Pan troglodytes
700853 Macaca mulatta
100062501 Equus caballus
100359412 Ovis aries
23089 Homo sapiens
482307 Canis lupus familiaris
654416 Sus scrofa
618138 Bos taurus
170676 Mus musculus
678843 Rattus norvegicus
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