anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Antibodies

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. Additionally we are shipping Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteins (20) and Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PIN1 241593  
PIN1 5300 Q13526
PIN1 298696  
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Top anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Antibodies at antibodies-online.com

Showing 10 out of 218 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with insulin 0.01U/ml 15', using Pin1 (Phospho-Ser16) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human heart, using Pin1 (Phospho-Ser16) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of PIN1 Antibody (Center) (ABIN652906) in HL-60 cell line lysates (35 µg/lane). PIN1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PIN1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of NIH-3T3 cells, using Pin1 (Ab-1619) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$419.10
Details
Rat Goat Un-conjugated ELISA, WB ABIN185726 (0.2µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated WB Anti- PIN1 Picoband antibody, Western blotting All lanes: Anti PIN1  at 0.5ug/ml Lane 1: Rat Lung Tissue Lysate at 50ug Lane 2: Mouse Lung Tissue Lysate at 50ug Lane 3: NRK Whole Cell Lysate at 40ug Lane 4: A549 Whole Cell Lysate at 40ug Lane 5: 293T Whole Cell Lysate at 40ug Lane 6: MCF-7 Whole Cell Lysate at 40ug Predicted bind size: 19KD Observed bind size: 19KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated WB PIN1 Antibody (ABIN1882275) western blot analysis in Hela,293,mouse NIH/3T3,PC-12,COS-7 cell line and mouse brain,rat brain tissue lysates (35 µg/lane). This demonstrates the PIN1 antibody detected the PIN1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Chicken Un-conjugated ICC, IF, WB Immunocytochemistry/Immunofluorescence: Pin1 Antibody [NBP1-05424] - HeLa cells stained with NBP1-05424 antibody to Pin-1 (1:1000 dilution, green) and monoclonal to fibrillarin, ABIN438364 (red). Pin-1 stains the nuclear matrix and, much more faintly, the cytoplasm. The fibrillarin antibody marks nucleoli. Western Blot: Pin1 Antibody [NBP1-05424] - Western blot of whole HeLa cell homogenate stained with NBP1-05424, at dilution of 1:10000. A prominent band running with an apparent SDS-PAGE molecular weight of approx. 21kDa corresponds to Pin1. 0.1 mL Log in to see 7 to 9 Days
$381.94
Details
Rat Goat Un-conjugated ELISA, WB ABIN251689 (0.2?g/ml) staining of Rat Brain lysate (35?g protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details

PIN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Antibodies

  1. Human Polyclonal PIN1 Primary Antibody for ICC, IF - ABIN438364 : Islam, Bae, Yoon, Woo, Baek, Kim, Uchida, Ryoo: Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP. in Journal of cellular physiology 2014 (PubMed)
    Show all 2 references for 438364

  2. Cow (Bovine) Polyclonal PIN1 Primary Antibody for EIA, WB - ABIN401395 : Esnault, Shen, Whitesel, Malter: The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)
    Show all 2 references for 401395

  3. Human Polyclonal PIN1 Primary Antibody for IF, ELISA - ABIN1532476 : Lu, Hanes, Hunter: A human peptidyl-prolyl isomerase essential for regulation of mitosis. in Nature 1996 (PubMed)
    Show all 2 references for 1532476

  4. Rat (Rattus) Polyclonal PIN1 Primary Antibody for ELISA, WB - ABIN251689 : Pastorino, Sun, Lu, Zhou, Balastik, Finn, Wulf, Lim, Li, Li, Xia, Nicholson, Lu: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. in Nature 2006 (PubMed)

  5. Human Monoclonal PIN1 Primary Antibody for WB - ABIN1882275 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)

More Antibodies against Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Interaction Partners

Mouse (Murine) Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. in vivo functional analyses of Pin1 in the GFAP (show GFAP Antibodies)-tTA;TRE (show TREH Antibodies)-SmoA1 mouse model of Hedgehog (show SHH Antibodies)-driven medulloblastoma demonstrate that the loss of Pin1 impairs tumor development and dramatically increases survival.

  2. Data, including data from studies conducted with knockout mice, suggest that Pin1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (show INS Antibodies); Pin1 interacts with Sik2 (salt-inducible kinase 2 (show SIK2 Antibodies)) to regulate calcium signaling.

  3. Pin1 knockout in lupus-prone MRL lpr mi (show TLR7 Antibodies)ce pre (show TLR9 Antibodies)vents expres (show IRAK1 Antibodies)sion o (show IRF7 Antibodies)f lupus phenotype.

  4. By interacting with PSD-95 (show DLG4 Antibodies), Pin1 dampens PSD-95 (show DLG4 Antibodies) ability to complex with NMDARs, thus negatively affecting NMDAR (show GRIN1 Antibodies) signaling and spine morphology.

  5. Oral administration of brown algae polyphenol, a Pin1 inhibitor, reduced fat buildup in mice.

  6. The findings provide evidence for a putative novel role of PIN1 in the development of the nociceptive system and indicate phosphorylation-mediated conformational changes as a mechanism for regulating the PRRXL1 (show DRGX Antibodies) role in the process.

  7. Data show that peptidyl-prolyl isomerase (Pin1) inhibition inhibits high glucose (HG)-induced cardiac fibroblasts (CFs) proliferation and migration.

  8. Pin1 knock-out mice exhibited disturbed neuronal projections from the cerebral cortex and reduced white matter tracks.

  9. Pin1 plays a vital role on the development of vascular inflammation and atherosclerosis in ApoE (show APOE Antibodies)-/- mice.

  10. Studies indicate that Prolyl Isomerase Pin1 (Pin1) Is highly involved in the development of metabolic syndrome.

Xenopus laevis Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. Pin1 is an essential factor regulating CPEB degradation

  2. Pin1 binding is required for the inactivation of XeWee1B at M phase, presumably causing isomerization of the phospho-TP motif and thereby impairing the function of the Wee (show WEE1 Antibodies)-box

Human Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. The study demonstrates the oncogenic role of PIN1 in NPC (show NPC1 Antibodies) tumorigenesis, and shows that its overexpression can enhance tumor cell growth via the upregulation of cyclinD1.

  2. Pin1 expression was decreased remarkably in temporal lobe epilepsy patients compared to controls.

  3. Data, including data from studies conducted with knockout mice, suggest that PIN1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; PIN1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (show INS Antibodies); PIN1 interacts with Sik2 (salt-inducible kinase 2 (show SIK2 Antibodies)) to regulate calcium signaling.

  4. Knockdown of PIN1 potently blocks TLR-7 (show TLR7 Antibodies)/TLR-9 (show TLR9 Antibodies)/Pin1/IRAK-1 (show IRAK1 Antibodies)/IRF-7 (show IRF7 Antibodies) signaling in vitro.

  5. Data indicate the complexity of interactions between Pin1 and activated IRAK1 (show IRAK1 Antibodies), suggesting that phosphorylation of neighboring Ser (show SIGLEC1 Antibodies)/Thr (show TRH Antibodies)-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1.

  6. Surprisingly, the authors discover that Pin1 does not promote phosphorylated tau-induced microtubule formation in vitro, refuting the commonly accepted model in which Pin1 binding and catalysis on the A180 epitope restores the function of the Alzheimer's associated phosphorylated tau in tubulin (show TUBB Antibodies) assembly.

  7. Importantly, site-specific measurements of Pin1-catalysis of CDK2 (show CDK2 Antibodies)/CycA (show CCNA2 Antibodies)-phosphorylated full-length tau reveal a number of sites that are catalyzed simultaneously with different efficiencies.

  8. Results show that Pin1 plays a dual role, both positive and negative, in regulating NO production and in mediating the pathogenesis of cardiovascular diseases. Pin1 functions may vary a lot under different circumstances.

  9. reciprocal regulation of Pin1 and XBP1s is associated with the activation of oncogenic pathways, and the relationship of PIN1 and XBP1 (show XBP1 Antibodies) may be an attractive target for novel therapy in cancers

  10. When combined with the BRAF (show BRAF Antibodies)(V600E)-inhibitor PLX4032 a robust repression in melanoid viability was obtained, establishing preclinical value of patient-derived melanoids for prognostic use of drug sensitivity and further underscoring the beneficial effect of Pin1-FOXM1 (show FOXM1 Antibodies) inhibitory peptides as anti-melanoma drugs.

Cow (Bovine) Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. The data provide the first evidence that Pin 1 expression in the granulosa cells but not the theca cells changes during follicular development, and that FSH (show BRD2 Antibodies) stimulate the expression of the Pin 1 gene.

Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Antigen Profile

Protein Summary

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with PIN1

  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, retrogene 1 (Pin1rt1) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1-b) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1-a) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) antibody
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (ppiD) antibody
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PITG_11123) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Pin1) antibody
  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Pin1) antibody
  • 0610025L01Rik antibody
  • D9Bwg1161e antibody
  • DOD antibody
  • OTTMUSG00000014964 antibody
  • pin1 antibody
  • Pin1-ps1 antibody
  • pin1a antibody
  • pin1b antibody
  • Pin1l antibody
  • UBL5 antibody

Protein level used designations for PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1, pseudogene 1 , prolyl isomerase Pin1 b , prolyl isomerase Pin1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1 b , protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1 a , peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 , PPIase Pin1 , protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 , rotamase Pin1 , peptidyl-prolyl cis-trans isomerase Pin1

GENE ID SPECIES
241593 Mus musculus
399385 Xenopus laevis
493472 Xenopus (Silurana) tropicalis
503670 Xenopus laevis
711095 Macaca mulatta
745021 Pan troglodytes
5807350 Sorangium cellulosum So ce56
9476290 Phytophthora infestans T30-4
5300 Homo sapiens
484963 Canis lupus familiaris
298696 Rattus norvegicus
535470 Bos taurus
100512827 Sus scrofa
23988 Mus musculus
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