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PER2 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Additionally we are shipping PER2 Antibodies (69) and PER2 Kits (4) and many more products for this protein.
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possible circadian rhythm in full-term placental expression
Data suggest that PER2 functions as the only clock gene needed to maintain undifferentiated state of endothelial progenitor cells; expression of PER2-regulatory microRNA, miR (show MLXIP Proteins)-92a, is down-regulated in diabetic retinopathy.
ARNTL (show ARNTL Proteins) and PER2 genetic variants associate in psychotic disorders Depresssion
Data indicate that the period circadian protein Per2 modulates hp53 protein signaling in response to genotoxic stress.
In patients with non-small cell lung cancer, those with lower expression of Per1, Per2 and Per3 had a shorter survival time than those with higher expression.
We did not observe any significant difference in Bone Mineral Density according to the genotype of the PER2 c.3731G> A polymorphism in postmenopausal Korean women.
deregulated of the PER2 genes in glioma cells in deregulation of the cell cycle favoring proliferation of tumor cells.
RNA sequencing revealed that premature inhibition of PER2 by small interfering RNA knockdown leads to a grossly disorganized decidual response.
The biological effects of the per2 gene and its protein product, PER2, in the limbic system. [Review]
The findings place hPer2 directly at the heart of the hp53-mediated response by ensuring that basal levels of hp53 are available to precondition the cell when a rapid, hp53-mediated, transcriptional response is needed.
polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1 (show CRY1 Proteins)
Rate-limiting mitochondrial enzymes that process lipids and carbohydrates accumulate in a diurnal manner and are dependent on the clock proteins PER1/2. Diurnal regulation of mitochondrial respiration was blunted in PER1/2 knockout mice.
Decreased Bone Volume and Bone Mineral Density in the Tibial Trabecular Bone Is Associated with Per2 Gene by 405 nm Laser Stimulation
that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 and Per2 genes under abnormal light-dark conditions
Data show that early doors period 2 (PER2) I324N mutation (Per2 Edo) reveals a direct causal link between the molecular structure of the PER2 PAS (show PASK Proteins) domain and the pace of suprachiasmatic nucleus (SCN (show SRI Proteins)) circadian timekeeping.
PER2 ablation in the liver abolishes food anticipation via decreased beta-hydroxybutyrate production.
hnRNP C (show HNRNPC Proteins) and hnRNP H (show HNRNPH2 Proteins) bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2).
Histone monoubiquitination by Clock-Bmal1 (show ARNTL Proteins) complex marks Per1 and Per2 genes for circadian feedback.
clock genes (such as Per2) constitute a common pathway mediating the shared and well-known adverse effects of both chronic sleep loss and disrupted circadian rhythmicity on metabolic health
In mice, food intake stimulates oxyntomodulin secretion from the gut, which resets liver transcription rhythms via induction of the core clock genes Per1 and 2.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
period homolog 2
, circadian clock protein PERIOD 2
, period 2
, period circadian protein 2
, period circadian protein homolog 2