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PMP22 encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Additionally we are shipping PMP22 Kits (18) and PMP22 Proteins (8) and many more products for this protein.
Showing 10 out of 93 products:
Human Polyclonal PMP22 Primary Antibody for EIA, WB - ABIN954219
Kohl, Fischer, Groh, Wessig, Martini: MCP-1/CCL2 modifies axon properties in a PMP22-overexpressing mouse model for Charcot-Marie-tooth 1A neuropathy. in The American journal of pathology 2010
Show all 5 references for ABIN954219
Human Monoclonal PMP22 Primary Antibody for EIA, IHC (p) - ABIN1108677
Gregson, Zhang, Pritchard, Wang, Sanvito, Hayday, Hughes: Characterization of a monoclonal antibody specific for human peripheral myelin protein 22 and its use in immunohistochemical studies of the fetal and adult nervous system. in Journal of the peripheral nervous system : JPNS 2007
The results of this study indicated that an adequate pmp22 transcription level is necessary for correct myelination of jawed vertebrates.
our data suggest that an alteration of mRNA processing could be a pathogenic mechanism in CMT1A.
Data (including data from studies using recombinant proteins that lack typical in-vivo post-translational modifications such as palmitoylation) suggest PMP22 exhibits little tendency to partition into liquid-ordered domains of unilamellar vesicles.
PMP22 gene knockdown inhibited progression of Chronic Myeloid Leukemia (show BCL11A Antibodies).
The common 17p deletion accounts for approximately 50% and PMP22 micromutations for approximately 2% of cases in a large consecutive cohort of Greek patients with suspected HNPP.
This finding provides compelling evidence that the effects of these mutations on the energetics of PMP22 folding lie at the heart of the molecular basis of Charcot-Marie-Tooth disease.
DNA diagnosis was performed in 5 families with hereditary neuropathy with liability to pressure palsies - the PMP22 deletion was found in 9 patients.
Osteosarcoma metastasis-related gene PMP22 participates in the proliferation, invasion, migration and colony formation of osteosarcoma cells possibly via the MAPK (show MAPK1 Antibodies) signal transduction pathway
PMP22 is a transmembrane glycoprotein component of myelin, important for myelin functioning. Mutation of PMP22 gene cause Charcot-Marie-Tooth Disease.
PMP22 Gene Duplication is associated with Charcot-Marie-Tooth disease type 1A.
The results of this study revealed distinct patterns of SNP allele frequency distribution, which reliably differentiated CMT1A patients from controls
The basal lamina and PMP22 act in concert to contribute to a resilience and integrity of peripheral nerves at the single fibre level.
A role was identified for PMP22 in the linkage of the actin cytoskeleton with the plasma membrane.
This study demonistrated that Paranodal dysmyelination in peripheral nerves of Trembler mice.
This study showed that a number of ongoing pathogenic mechanisms contribute to the progression of the neuropathy in C22 mice, which initiates with abnormal expression of PMP22.
Pxmp2 in the mammary fat pad is plays a critical role in stromal lipid homeostasis and in development of mammary gland epithelium in mice
This study revealed a novel mechanism by which PMP22 deficiency affects nerve conduction not through removal of myelin, but through disruption of myelin junctions
This study showed that mouse PMP22 is palmitoylated at C85 and mutating C85S abolishes PMP22 palmitoylation.
Peripheral myelin protein 22 (PMP22) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath.
Egr2 (show EGR2 Antibodies) and Sox10 (show SOX10 Antibodies) activity are directly involved in mediating the developmental induction of Pmp22 expression through an intronic enhancer.
The results of this study demonstrated that a function of Pmp22 is to protect the nerve from mechanical injury.
This gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing of this gene results in three transcript variants that encode the same protein.
peripheral myelin protein 22
, growth arrest-specific protein 3
, SR13 myelin protein
, schwann cell membrane glycoprotein
, peripheral myelin protein, 22 kDa
, PAS positive glycoprotein
, 22 kDa peroxisomal membrane protein
, peroxisomal membrane protein 2, 22 kDa