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Peripheral Myelin Protein 22 Proteins (PMP22)

PMP22 encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Additionally we are shipping PMP22 Antibodies (78) and PMP22 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PMP22 5376 Q01453
Rat PMP22 PMP22 24660 P25094
PMP22 18858 P16646
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Top PMP22 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$686.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$857.60
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PMP22 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Peripheral Myelin Protein 22 (PMP22) Interaction Partners

Zebrafish Peripheral Myelin Protein 22 (PMP22) interaction partners

  1. The results of this study indicated that an adequate pmp22 transcription level is necessary for correct myelination of jawed vertebrates.

Human Peripheral Myelin Protein 22 (PMP22) interaction partners

  1. our data suggest that an alteration of mRNA processing could be a pathogenic mechanism in CMT1A.

  2. Data (including data from studies using recombinant proteins that lack typical in-vivo post-translational modifications such as palmitoylation) suggest PMP22 exhibits little tendency to partition into liquid-ordered domains of unilamellar vesicles.

  3. PMP22 gene knockdown inhibited progression of Chronic Myeloid Leukemia (show BCL11A Proteins).

  4. The common 17p deletion accounts for approximately 50% and PMP22 micromutations for approximately 2% of cases in a large consecutive cohort of Greek patients with suspected HNPP.

  5. This finding provides compelling evidence that the effects of these mutations on the energetics of PMP22 folding lie at the heart of the molecular basis of Charcot-Marie-Tooth disease.

  6. DNA diagnosis was performed in 5 families with hereditary neuropathy with liability to pressure palsies - the PMP22 deletion was found in 9 patients.

  7. Osteosarcoma metastasis-related gene PMP22 participates in the proliferation, invasion, migration and colony formation of osteosarcoma cells possibly via the MAPK (show MAPK1 Proteins) signal transduction pathway

  8. PMP22 is a transmembrane glycoprotein component of myelin, important for myelin functioning. Mutation of PMP22 gene cause Charcot-Marie-Tooth Disease.

  9. PMP22 Gene Duplication is associated with Charcot-Marie-Tooth disease type 1A.

  10. The results of this study revealed distinct patterns of SNP allele frequency distribution, which reliably differentiated CMT1A patients from controls

Mouse (Murine) Peripheral Myelin Protein 22 (PMP22) interaction partners

  1. The basal lamina and PMP22 act in concert to contribute to a resilience and integrity of peripheral nerves at the single fibre level.

  2. A role was identified for PMP22 in the linkage of the actin cytoskeleton with the plasma membrane.

  3. This study demonistrated that Paranodal dysmyelination in peripheral nerves of Trembler mice.

  4. This study showed that a number of ongoing pathogenic mechanisms contribute to the progression of the neuropathy in C22 mice, which initiates with abnormal expression of PMP22.

  5. Pxmp2 in the mammary fat pad is plays a critical role in stromal lipid homeostasis and in development of mammary gland epithelium in mice

  6. This study revealed a novel mechanism by which PMP22 deficiency affects nerve conduction not through removal of myelin, but through disruption of myelin junctions

  7. This study showed that mouse PMP22 is palmitoylated at C85 and mutating C85S abolishes PMP22 palmitoylation.

  8. Peripheral myelin protein 22 (PMP22) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath.

  9. Egr2 (show EGR2 Proteins) and Sox10 (show SOX10 Proteins) activity are directly involved in mediating the developmental induction of Pmp22 expression through an intronic enhancer.

  10. The results of this study demonstrated that a function of Pmp22 is to protect the nerve from mechanical injury.

PMP22 Protein Profile

Protein Summary

This gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing of this gene results in three transcript variants that encode the same protein.

Gene names and symbols associated with PMP22

  • peripheral myelin protein 22a (pmp22a)
  • peripheral myelin protein 22 (PMP22)
  • peripheral myelin protein 22 (pmp22)
  • peripheral myelin protein 22 (Pmp22)
  • peroxisomal membrane protein 2 (Pxmp2)
  • 22kDa protein
  • CMT1A protein
  • CMT1E protein
  • DSS protein
  • Gas-3 protein
  • HMSNIA protein
  • HNPP protein
  • MGC69407 protein
  • MGC80653 protein
  • PMP22 protein
  • Sp110 protein
  • Tr protein
  • trembler protein
  • wu:fa04d03 protein
  • wu:fa08d03 protein

Protein level used designations for PMP22

peripheral myelin protein 22 , growth arrest-specific protein 3 , PMP-22 , SAG , SR13 myelin protein , schwann cell membrane glycoprotein , peripheral myelin protein, 22 kDa , PAS positive glycoprotein , PASII , 22 kDa peroxisomal membrane protein , peroxisomal membrane protein 2, 22 kDa

GENE ID SPECIES
334817 Danio rerio
417327 Gallus gallus
446837 Xenopus laevis
479509 Canis lupus familiaris
594946 Xenopus (Silurana) tropicalis
100302348 Ovis aries
5376 Homo sapiens
24660 Rattus norvegicus
18858 Mus musculus
534497 Bos taurus
100034146 Equus caballus
693527 Macaca mulatta
744977 Pan troglodytes
100172535 Pongo abelii
19301 Mus musculus
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