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Peripherin Proteins (PRPH)

PRPH encodes a cytoskeletal protein found in neurons of the peripheral nervous system. Additionally we are shipping Peripherin Antibodies (128) and Peripherin Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRPH 5630 P41219
PRPH 19132  
PRPH 24688  
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Top Peripherin Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,281.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,318.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,322.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PRPH Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Peripherin Proteins

  1. Human Peripherin Protein expressed in Wheat germ - ABIN1316403 : Mizuno, Fujita, Takatama, Okamoto: Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis. in Journal of the neurological sciences 2011 (PubMed)

More Proteins for Peripherin (PRPH) Interaction Partners

Human Peripherin (PRPH) interaction partners

  1. interaction between disease-causing RAB7A (show RAB7A Proteins) mutants and peripherin could play an important role in Charcot-Marie-Tooth type 2B neuropathy

  2. This work contributes to determine the role of PRPH gene variants in ALS. Further studies are necessary to define the mechanisms through which the mutant peripherin could cause ALS phenotype.

  3. study analyzed expression of peripherin(PP) in the cochlea; in organ of Corti, PP seems to be specifically expressed in outer hair cell afferents; small or type II spiral ganglion cell bodies also intensely express PP

  4. although the mechanisms underlying peripherin co-localization in Bunina bodies are unknown, peripherin could be involved in forming these inclusions

  5. Transgenic peripherin isoform expression reveals post-transcriptional changes to the normal expression pattern associated with malformed filaments and intracellular inclusions underlying a role in the pathogenesis of amyotrophic lateral sclerosis.

  6. The data of this experiment document the expression of peripherin in Lewy body-like inclusions , which may provide a clue to the pathogenesis of neurodegeneration in ALS.

  7. Peripherin overexpression in transgenic mice can cause defective transport of type IV neurofilament proteins, a phenomenon that may account for the progressive formation of amyotrophic lateral sclerosis-like spheroids in axons.

  8. peripherin is a novel substrate for Akt (show AKT1 Proteins) in vivo and its phosphorylation may play a role in motor nerve regeneration

  9. Novel C165R mutation of retinal degeneration slow (show PRPH2 Proteins)/peripherin gene in family affected by different patterns of retinal dystrophy (show MERTK Proteins).

  10. Peripherin splicing abnormalities occur in amyotrophic lateral sclerosis generating aggregation-prone splice isoforms, one of which causes peripherin aggregation when its expression is upregulated.

Mouse (Murine) Peripherin (PRPH) interaction partners

  1. Eliminating Cngb1 (show CNGB1 Proteins) and reducing RDS (show PRPH2 Proteins) leads to additive defects in RDS (show PRPH2 Proteins) expression levels and rod electroretinogram (ERG (show ERG Proteins)) function, (e.g., Cngb1 (show CNGB1 Proteins)-/-/rds (show PRPH2 Proteins)+/- versus rds (show PRPH2 Proteins)+/- or Cngb1 (show CNGB1 Proteins)-/-) but not to additive defects in rod ultrastructure.

  2. In the group of mice manifesting homozygous mutation in the PRPH2 (show PRPH2 Proteins) gene.

  3. Our data suggest that upregulation of PRPH2 (show PRPH2 Proteins) levels in combination with defects in the PRPH2 (show PRPH2 Proteins) function caused by the mutation might be an important mechanism leading to cone degeneration.

  4. Contralateral and ipsilateral olivocochlear efferent-mediated suppression of the cochlear amplifier were absent in Prph null mice.

  5. These data suggest that glycosylation of RDS (show PRPH2 Proteins) is required for RDS (show PRPH2 Proteins) function or stability in cones, a difference that may be due to extracellular versus intradiscal localization of the RDS (show PRPH2 Proteins) glycan in cones versus rods.

  6. Peripherin-2 links CNGB1 to the light-detector rhodopsin in outer segments of rod photoreceptors.

  7. Expression of R172W mutation in cones induced subtle alterations in RDS (show PRPH2 Proteins)/ROM-1 (show ROM1 Proteins) complex assembly, specifically resulting in the formation of abnormal, large molecular weight ROM-1 (show ROM1 Proteins) complexes. Fundus imaging demonstrated that R172W mice developed macular degeneration.

  8. Data suggest anti-peripherin (PRPH) B cells represent a heterogeneous population that is generated early in life but proliferates as diabetes is established.

  9. Correcting the levels of RDS (show PRPH2 Proteins) gene expression does not improve the phenotype of the rd7 (show NR2E3 Proteins) model of enhanced S-cone syndrome.

  10. peripherin appears to be a participant in learning and memory impairment in mice

Peripherin (PRPH) Protein Profile

Protein Summary

This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis.

Gene names and symbols associated with Peripherin Proteins (PRPH)

  • peripherin (PRPH)
  • peripherin (prph)
  • peripherin (Prph)
  • peripherin (LOC100357822)
  • peripherin 2 (Prph2)
  • AOFMD protein
  • AVMD protein
  • if3 protein
  • MGC69454 protein
  • NEF4 protein
  • Nmf193 protein
  • Perf protein
  • plasticin protein
  • PRPH protein
  • Prph1 protein
  • Rd-2 protein
  • Rd2 protein
  • rds protein
  • RP7 protein
  • Tspan22 protein

Protein level used designations for Peripherin Proteins (PRPH)

peripherin , peripherin 1 , neurofilament 4 (57kD) , neuronal intermediate filament IF3 , peripherin-2 , retinal degeneration 2 , retinal degeneration slow protein , retinal degeneration, slow (retinitis pigmentosa 7)

GENE ID SPECIES
100059208 Equus caballus
407916 Xenopus (Silurana) tropicalis
5630 Homo sapiens
510082 Bos taurus
19132 Mus musculus
24688 Rattus norvegicus
477618 Canis lupus familiaris
100152434 Sus scrofa
380221 Xenopus laevis
100357822 Oryctolagus cuniculus
101082247 Felis catus
19133 Mus musculus
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