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anti-Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) Antibodies

The protein encoded by PHEX is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. Additionally we are shipping PHEX Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PHEX 5251 P78562
PHEX 25512  
PHEX 18675 P70669
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Top anti-PHEX Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PHEX Antibody (C-term) in 293 cell line lysates (35ug/lane). This demonstrates the PHEX antibody detected the PHEX protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB PHEX Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PHEX antibody detected the PHEX protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 ug whole cell lysate) A:MOLT4 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Rat Rabbit Un-conjugated ELISA, WB   50 μg Log in to see 8 to 10 Days
$610.50
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$405.17
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 6 to 11 Days
$485.71
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details

PHEX Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus) ,


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Top referenced anti-PHEX Antibodies

  1. Human Polyclonal PHEX Primary Antibody for EIA, WB - ABIN954116 : Majewski, Thurston, Ramalingam, Kiela, Ghishan: Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN954116

More Antibodies against PHEX Interaction Partners

Human Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) interaction partners

  1. This report that mutations in PHEX are the most frequent cause of hypophosphatemic rickets

  2. Downregulation of PHEX may constitute an important early component of bone loss and joint damage in leprosy

  3. PHEX c.*231A > G can masquerade as sporadic or X-linked recessive HR.

  4. A novel de novo nonsense mutation of the PHEX gene has been identified in Chinese family expanding the mutation spectrum of PHEX leading to X-linked hypophosphatemic rickets.

  5. exon 22 is the mutation hot spot and missense mutation is the most common type of mutation in the PHEX gene in Chinese X-link dominate hypophosphatemic rickets (XLH) patients

  6. 15 PHEX mutations have been reported in Chinese populations with X-linked hypophosphatemic rickets

  7. The c.732+1G>T mutation of PHEX is associated with hypophosphatasia pedigree.

  8. study shows that PHEX mutation is a common cause of either familial or sporadic hypophosphatemic rickets in Turkish population

  9. Mutations in PHEX and DMP1 (show DMP1 Antibodies) play a role in causing hypophosphatemic rickets.

  10. PHEX gene mutations were responsible for X-linked hypophosphatemia in these Chinese families.

Mouse (Murine) Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) interaction partners

  1. the phex mutation may create the lower set point for extracellular phosphate concentrations in a murine model of X-linked hypophosphatemia

  2. Hyp/Lrp6 (show LRP6 Antibodies) double mutants developed the same reduced bone mineralization,hypophosphatemia & high FGF23 (show FGF23 Antibodies) levels as Hyp(-) mice, showing that WNT (show WNT2 Antibodies) signaling does not affect the FGF23 (show FGF23 Antibodies)-induced phosphate wasting.

  3. demonstrates a previously unknown impact of retinol on the cell-autonomous mineralization defect of Phex-deficient osteoblasts

  4. results identify full-length OPN (show SPP1 Antibodies) as novel, physiologically relevant substrates for PHEX, suggesting accumulation of mineralization-inhibiting OPN (show SPP1 Antibodies) fragments may contribute to the mineralization defect seen in the osteomalacic bone characteristic of XLH/HYP

  5. Mutation in Phex gene predisposes BALB/c-Phex(Hyp-Duk)/Y mice to otitis media.

  6. These data suggest that Phex mutations alter the responsiveness of bone cells to extracellular phosphate concentrations and may create a lower set point for "normal" phosphate levels.

  7. PHEX and DMP1 (show DMP1 Antibodies) control a common pathway regulating bone mineralization and FGF23 (show FGF23 Antibodies) production, the latter involving activation of the FGFR (show FGFR2 Antibodies) signaling in osteocytes.

  8. ASARM peptides likely play a bone PHEX-dependent role in renal phosphate regulation and FGF23 (show FGF23 Antibodies) expression.

  9. Cooperative role of NF-{kappa}B (show NFKB1 Antibodies) and poly(ADP-ribose) polymerase 1 (PARP-1 (show PARP1 Antibodies)) in the TNF (show TNF Antibodies)-induced inhibition of PHEX expression in osteoblasts.

  10. OPN (show SPP1 Antibodies) ASARM inhibits mineralization by binding to hydroxyapatite in a phosphorylation-dependent manner and can be cleaved by PHEX.

PHEX Antigen Profile

Protein Summary

The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets.

Gene names and symbols associated with PHEX

  • phosphate regulating endopeptidase homolog, X-linked (PHEX) antibody
  • phosphate regulating endopeptidase homolog, X-linked (Phex) antibody
  • phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) (Phex) antibody
  • Gy antibody
  • HPDR antibody
  • HPDR1 antibody
  • Hyp antibody
  • HYP1 antibody
  • LXHR antibody
  • PEX antibody
  • XLH antibody

Protein level used designations for PHEX

X-linked hypophosphatemia protein , metalloendopeptidase homolog PEX , phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) , phosphate-regulating neutral endopeptidase , vitamin D-resistant hypophosphatemic rickets protein , phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets) , Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH) , Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein) , X-linked phosphate regulating endopeptidase , phosphate regulating neutral endopeptidase

GENE ID SPECIES
5251 Homo sapiens
480862 Canis lupus familiaris
100154258 Sus scrofa
536029 Bos taurus
25512 Rattus norvegicus
18675 Mus musculus
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