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Phosphatidylinositol Glycan Anchor Biosynthesis, Class A Proteins (PIGA)

PIGA encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. Additionally we are shipping PIGA Antibodies (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIGA 5277 P37287
PIGA 18700 Q64323
Rat PIGA PIGA 363464  
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Top PIGA Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

PIGA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA) Interaction Partners

Human Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA) interaction partners

  1. A recurrent germline mutation in the PIGA gene causes Simpson-Golabi-Behmel syndrome type 2.

  2. This case reports on a new missense PIGA germline mutation in a Chinese male infant presenting with developmental arrest and multisystemic disorders.

  3. the PIGA mutation in this family likely causes a reduction in GPI (show GNPDA1 Proteins) anchor protein (show CELSR3 Proteins) cell surface expression in various cell types, resulting in the observed pleiotropic phenotype involving central nervous system, skin, and iron metabolism.

  4. Our data strongly suggest that the early frameshift mutation in PIGA produces a truncated hypomorph, which is sufficient to rescue the lethality in males but not the MCAHS2-like phenotype.

  5. The results of this study confirmed that PIGA mutations are one genetic cause of early-onset epileptic encephalopathies, suggesting that GPI (show GNPDA1 Proteins)-anchor deficiencies may be an underlying cause of EOEE.

  6. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells.

  7. An X chromosome exome next-generation sequencing screen identified a single nonsense PIGA mutation.

  8. loss of PIG-A or a combination of genes within the 0.5 Mb commonly deleted region leads to a phenotype capable of avoiding immune surveillance, but is not inherently malignant.

  9. the PIG-A mutations in paroxysmal nocturnal hemoglobinuria patients

  10. Molecular testing for mutations in the PIG-A gene can serve as a confirmation test of paroxysmal nocturnal hemoglobinuria.

Mouse (Murine) Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA) interaction partners

  1. Single cell gel electrophoresis (SCGE (show SGCE Proteins)) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1 (show OGG1 Proteins)(-/-) mice.

  2. Reduced IgE/antigen-mediated passive cutaneous anaphylaxis is detected in mice with Piga-deficient mast cells.

  3. Deletion of the Pig-a gene in hematopoietic cells does not cause frank marrow failure but leads to the appearance of clonally-restricted, inactive yet functionally competent CD8 (show CD8A Proteins) T cells.

  4. Piga gene mutation does not alter susceptibility to cell death in thymocytes, granulocytes, and hematopoietic progenitor cells.

  5. Pig-a-knockout females are infertile, and eggs recovered from the females after mating are unfertilized.

  6. processing profilaggrin (show FLG Proteins) to its monomeric form was impaired in Pig-a null mouse epidermis

  7. Piga expression is required to properly orient hair cells in the inner ear, a process regulated by the planar cell polarity pathway.

PIGA Protein Profile

Protein Summary

This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.

Gene names and symbols associated with PIGA

  • phosphatidylinositol glycan anchor biosynthesis, class A (PIGA)
  • phosphatidylinositol glycan anchor biosynthesis, class A (Piga)
  • AI194334 protein
  • GPI3 protein
  • MCAHS2 protein
  • Pig-a protein

Protein level used designations for PIGA

N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein , phosphatidylinositol glycan anchor biosynthesis, class A (paroxysmal nocturnal hemoglobinuria) , phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria) , GLCNAC-PI synthesis protein , GPI anchor biosynthesis , class A GlcNAc-inositol phospholipid assembly protein , phosphatidylinositol N-acetylglucosaminyltransferase subunit A , phosphatidylinositol-glycan biosynthesis, class A protein , glcNAc-PI synthesis protein , phosphatidylinositol glycan, class A , phosphatidylinositol-glycan biosynthesis class A protein , phosphatidylinositolglycan class A

GENE ID SPECIES
418624 Gallus gallus
100055827 Equus caballus
100156880 Sus scrofa
5277 Homo sapiens
491748 Canis lupus familiaris
100139601 Bos taurus
18700 Mus musculus
363464 Rattus norvegicus
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