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anti-Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1) Antibodies

The protein encoded by PREX1 acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). Additionally we are shipping PREX1 Kits (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PREX1 57580 Q8TCU6
PREX1 277360 Q69ZK0
PREX1 311647  
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Top anti-PREX1 Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PREX1 Antibody (Center) in MCF-7 cell line lysates (35µg/lane). PREX1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB PREX1 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. PREX1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PREX1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB PREX1 Antibody (C-term) (ABIN656506) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Goat Un-conjugated EIA, IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) PREX1 antibody (1 µg/ml) staining of Human Temporal Cortex lysate (35 µg protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of PREX1 Antibody (Center) (ABIN653415) in MCF-7 cell line lysates (35 µg/lane). PREX1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit APC FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details

PREX1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-PREX1 Antibodies

  1. Human Polyclonal PREX1 Primary Antibody for EIA, WB - ABIN954296 : Carretero-Ortega, Walsh, Hernández-García, Reyes-Cruz, Brown, Vázquez-Prado: Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac in Molecular pharmacology 2010 (PubMed)
    Show all 5 references for ABIN954296

  2. Human Polyclonal PREX1 Primary Antibody for EIA, WB - ABIN954297 : Lewis, Palmer, Ellington, Divers, Ng, Lu, Langefeld, Freedman, Bowden: Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. in Genomics 2010 (PubMed)
    Show all 3 references for ABIN954297

  3. Cow (Bovine) Polyclonal PREX1 Primary Antibody for EIA, WB - ABIN453976 : Qin, Xie, Wang, Hoshino, Wolff, Zhao, Scofield, Dowd, Lin, Tu: Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. in Oncogene 2009 (PubMed)

More Antibodies against PREX1 Interaction Partners

Human Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1) interaction partners

  1. P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism.

  2. findings suggest a vital role of P-Rex1 signaling in CA1 (show CA1 Antibodies) LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs

  3. The P-Rex1-Rac1 interface is critical for Rac1 activation in breast cancer cells.

  4. P-REX1 promotes both PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling in breast cancer.

  5. PREX1 gene promoter hypomethylation is a prognostic marker of poor patient survival.

  6. Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R (show IGF1R Antibodies) signaling in breast cancer cells.

  7. Cucurbitacin I also failed to affect the activation of P-Rex1 by heregulin (show NRG1 Antibodies).

  8. These data suggest that P-Rex1 has an influence on physiological migratory processes, such as invasion of cancer cells, both through effects upon classical Rac1-driven motility and a novel association with RTK signalling complexes.

  9. Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 (show VAV2 Antibodies) and Vav3 (show VAV3 Antibodies) play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis.

  10. We have identified a novel mechanism for direct activation of P-Rex1 through PP1alpha (show PPP1CA Antibodies)-dependent dephosphorylation.

Mouse (Murine) Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1) interaction partners

  1. A novel mechanism of P-Rex1 regulation through the GPCR (show GPBAR1 Antibodies)-adaptor protein Norbin (show NCDN Antibodies).

  2. Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.

  3. findings suggest a vital role of P-Rex1 signaling in CA1 (show CA1 Antibodies) LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs

  4. regulates GPCR-driven Rac signalling and actin polarity in neutrophils

  5. Platelet P-Rex and Vav (show VAV1 Antibodies) family Rac (show AKT1 Antibodies)-GEFs play important proinflammatory roles in leukocyte recruitment.

  6. We have elucidated a proliferative role of P-Rex1 when Rac1 is deleted in melanoblasts.

  7. P-Rex1 may serve as a biomarker to predict response to single-agent PI3K inhibitors within a subset of breast cancers.

  8. In vivo, in an ischemia-reperfusion-induced model of acute kidney injury, abolished selectin-mediated integrin activation contributed to decreased neutrophil recruitment and reduced kidney damage in P-Rex1-deficient mice.

  9. P-rex1 expressed in endothelial cells is a critical mediator of vascular barrier disruption by an upstream pathway.

  10. Data conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans.

PREX1 Antigen Profile

Protein Summary

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

Gene names and symbols associated with PREX1

  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (prex1) antibody
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (PREX1) antibody
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (Prex1) antibody
  • G630042G04 antibody
  • MGC68772 antibody
  • P-REX1 antibody
  • RGD1306534 antibody
  • Setd6 antibody

Protein level used designations for PREX1

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 , phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1 , phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like , phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein , ptdIns(3,4,5)-dependent Rac exchanger 1 , SET domain containing 6

GENE ID SPECIES
399069 Xenopus laevis
419210 Gallus gallus
714351 Macaca mulatta
100029404 Monodelphis domestica
100075289 Ornithorhynchus anatinus
100220665 Taeniopygia guttata
100357266 Oryctolagus cuniculus
100436617 Pongo abelii
100467037 Ailuropoda melanoleuca
100488039 Xenopus (Silurana) tropicalis
100564517 Anolis carolinensis
100601640 Nomascus leucogenys
57580 Homo sapiens
485917 Canis lupus familiaris
527410 Bos taurus
277360 Mus musculus
311647 Rattus norvegicus
Selected quality suppliers for anti-PREX1 (PREX1) Antibodies
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