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Phospholamban (PLN) ELISA Kits

The protein encoded by PLN is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. Additionally we are shipping Phospholamban Antibodies (124) and Phospholamban Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PLN 5350 P26678
PLN 18821 P61014
PLN 64672 P61016
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Top Phospholamban ELISA Kits at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.057 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$720.00
Details
Human 0.113 ng/mL 0.31-20 ng/mL 96 Tests Log in to see 9 to 11 Days
$736.84
Details
Chicken
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Guinea Pig
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Pig
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Monkey
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Rabbit
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Rat
  96 Tests Log in to see 11 to 13 Days
$785.71
Details
Dog
  96 Tests Log in to see 11 to 13 Days
$801.43
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Goat
  96 Tests Log in to see 11 to 13 Days
$801.43
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More ELISA Kits for Phospholamban Interaction Partners

Human Phospholamban (PLN) interaction partners

  1. PLN may be a key molecular player in rigid substrate-induced cellular hypertrophy in eosinophilic esophagitis.

  2. These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys (show LYZ ELISA Kits)(3) and degraded through Ser (show SIGLEC1 ELISA Kits)(16)-phosphorylation-mediated poly-ubiquitination during heart failure.

  3. hereditary mutants of phospholamban are associated with heart failure [review]

  4. PLN pentamers reduce phosphorylation of monomers at baseline and delay monomer phosphorylation upon PKA stimulation leading to increased interaction of PLN monomers with SERCA2a (show ATP2A2 ELISA Kits).

  5. Phospholamban R14del mutation carriers are at high risk for malignant ventricular arrhythmias and end-stage heart failure, with left ventricular ejection fraction <45% and sustained or nonsustained ventricular tachycardia as independent risk factors.

  6. Although SLN (show SLN ELISA Kits) and PLB binding to SERCA (show ATP2A3 ELISA Kits) have different functional outcomes on the coupling efficiency of SERCA (show ATP2A3 ELISA Kits), both proteins decrease the apparent Ca(2 (show CA2 ELISA Kits)+) affinity of the pump, suggesting that SLN (show SLN ELISA Kits) and PLB inhibit SERCA (show ATP2A3 ELISA Kits) by using a similar mechanism.

  7. Phospholamban, and its interacting partners, regulates excitation contraction coupling and myocardial contraction. [Review]

  8. PLN mutations rarely cause cardiomyopathy

  9. analysis of how the conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation

  10. Aim of the present study is to determine the exact pattern of fibrosis and fatty replacement in PLN p.Arg14del mutation positive patients.

Pig (Porcine) Phospholamban (PLN) interaction partners

  1. Phosphorylation of PLB induces spatial rearrangements between the N- and P-domain elements of proximal Ca-ATPase (show CA-P60A ELISA Kits).

  2. Molecular dynamics simulations of phospholamban in solution and in membrane bilayer show two main features: the presence of two well-defined helical domains at the N- and C-termini, and large-amplitude rigid-body motions of these domains.

  3. The expression of SLN (show SLN ELISA Kits) and PLB mRNA and protein relative to SERCA1 (show ATP2A1 ELISA Kits) or SERCA2 (show ATP2A2 ELISA Kits) was assessed in ventricle, atrium, and skeltal msucle of mouse, rat, rabbit and pig.

Mouse (Murine) Phospholamban (PLN) interaction partners

  1. These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys (show LYZ ELISA Kits)(3) and degraded through Ser (show SIGLEC1 ELISA Kits)(16)-phosphorylation-mediated poly-ubiquitination during heart failure.

  2. the commercially available overexpressing phospholamban mouse phenotypically resembles human Centronuclear myopathy and could be used as a model to test potential mechanisms and therapeutic strategies.

  3. Cardioprotective effects of H2S are mediated through acGMP/PKG (show PRKG1 ELISA Kits)/phospholamban pathway.

  4. PLN pentamers reduce phosphorylation of monomers at baseline and delay monomer phosphorylation upon PKA stimulation leading to increased interaction of PLN monomers with SERCA2a (show ATP2A2 ELISA Kits).

  5. combined deletion of Phd2 (show EGLN1 ELISA Kits) and Phd3 (show EGLN3 ELISA Kits) dramatically decreased expression of phospholamban (PLN), resulted in sustained activation of calcium/calmodulin-activated kinase II (CaMKII (show CAMK2G ELISA Kits)), and sensitized mice to chronic beta-adrenergic stress-induced myocardial injury

  6. the N termini of SLN (show SLN ELISA Kits) and PLB influence their respective unique functions

  7. CaMKII (show CAMK2G ELISA Kits)-dependent increase in PLN phosphorylation during reperfusion opposes rather than contributes to ischemia/reperfusion damage.

  8. TNAP (show ALPL ELISA Kits) plays a role in governing the phosphorylation status of phospholamban in the sarcoplasmic reticulum.

  9. SLN (show SLN ELISA Kits) and PLN are co-expressed in most fibers, which suggests that super-inhibition of SERCAs may be physiologically important in the regulation of intracellular Ca2 (show CA2 ELISA Kits)+ in human skeletal muscle.

  10. Epac1 (show RAPGEF3 ELISA Kits) KO exhibited decreased cardiac contractility with reduced phospholamban (PLN) phosphorylation at serine-16, the major PKA-mediated phosphorylation site.

Rabbit Phospholamban (PLN) interaction partners

  1. Acute expression of R9C mutation of phospholamban in cardiomyocytes was positively inotropic/lusitropic.

  2. Ca(2 (show CA2 ELISA Kits)+) and PLB phosphorylation relieve SERCA (show ATP2A3 ELISA Kits)-PLB inhibition by distinct mechanisms, but both are achieved primarily by structural changes within the SERCA (show ATP2A3 ELISA Kits)-PLB complex, not by dissociation of that complex.

  3. Phosphorylated phospholamban stabilizes a unique conformation of SERCA (show ATP2A3 ELISA Kits) that is characterized by a compact architecture.

  4. Data suggest that phospholamban PLN's conformational equilibrium is central to maintain sarcoplasmic reticulum Ca(2+)-ATPase (show CA-P60A ELISA Kits) SERCA's apparent Ca(2 (show CA2 ELISA Kits)+) affinity within a physiological window.

  5. demonstrate that the role of Arg(9) in phospholamban function is multifaceted: it is important for inhibition of SERCA (show ATP2A3 ELISA Kits), it increases the efficiency of phosphorylation, and it is critical for protein kinase A recognition

  6. The interaction energies between the N-terminal helix of phospholamban and different POPC lipid/cholesterol bilayers quantitatively confirm its stronger interaction with a higher cholesterol-containing membrane.

  7. The lipid bilayer composition influences the regulation of SERCA (show ATP2A3 ELISA Kits) by PLN.

  8. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport.

Phospholamban (PLN) Antigen Profile

Antigen Summary

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

Gene names and symbols associated with Phospholamban (PLN) ELISA Kits

  • phospholamban (LOC100226261) antibody
  • phospholamban (pln) antibody
  • phospholamban (PLN) antibody
  • phospholamban (Pln) antibody
  • CMD1P antibody
  • CMH18 antibody
  • LOC100226261 antibody
  • Plb antibody
  • Plm antibody

Protein level used designations for Phospholamban (PLN) ELISA Kits

phospholamban , cardiac phospholamban , PLB

GENE ID SPECIES
100226261 Taeniopygia guttata
100379739 Xenopus (Silurana) tropicalis
5350 Homo sapiens
414755 Canis lupus familiaris
397421 Sus scrofa
101102067 Ovis aries
18821 Mus musculus
64672 Rattus norvegicus
100721387 Cavia porcellus
100125240 Bos taurus
100009299 Oryctolagus cuniculus
396378 Gallus gallus
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