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PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and di. Additionally we are shipping and many more products for this protein.
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A molecular model of the PLCeta2 EF-hand domain, constructed based upon the structure of calmodulin (show CALM1 Antibodies), suggested both EF-loops may participate in Ca(2 (show CA2 Antibodies)+) -binding.
The PLCH1 rs181696 single-nucleotide polymorphism was strongly associated with an increased risk of squamous cell carcinoma.
molecular cloning of PLC-eta1 and PLC-eta2
The identification of a novel PLC (show HSPG2 Antibodies) isoform in the brains of human and mouse, named PLC (show HSPG2 Antibodies)-eta, which contains the conserved pleckstrin (show PLEK Antibodies) homology domain, X and Y domains for catalytic activity and the C2 domain.
Study concludes that perinuclear PLCepsilon, scaffolded to mAKAP (show Akap6 Antibodies) in cardiac myocytes, responds to hypertrophic stimuli to generate diacylglycerol (DAG) from PI4P in the Golgi apparatus, in close proximity to the nuclear envelope, to regulate activation of nuclear PKD (show PRKD1 Antibodies) and hypertrophic signaling pathways.
Phospholipase C (show PLC Antibodies)-eta was found to be expressed in mouse beta-cells, and knockout of that gene disrupts the action of exendin-4 to facilitate calcium-induced calcium release in the beta-cells of these mice.
PLC (show HSPG2 Antibodies)-eta1 (show SPP1 Antibodies) is activated via intracellular calcium mobilization from the endoplasmic reticulum, and therefore amplifies G-protein coupled receptor (show GPR34 Antibodies) mediated signaling
molecular cloning of PLC-eta1 and PLC-eta2.
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005
phospholipase C, eta 1
, phospholipase C eta 1
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1
, PLC eta 1
, phosphoinositide phospholipase C-eta-1
, phospholipase C-eta-1
, phospholipase C-eta1a
, phospholipase C-eta1b
, phospholipase C-like 3
, phospholipase C-like protein 3