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The protein encoded by PLTP is one of at least two lipid transfer proteins found in human plasma. Additionally we are shipping PLTP Antibodies (78) and PLTP Proteins (10) and many more products for this protein.
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identification and characterization of CaM (show CALM ELISA Kits)-binding domain of non-specific lipid transfer proteins
a novel association between PLTPa and PON1 (show PON1 ELISA Kits) activity
The domain of apolipoprotein E4 required for PLTP activation resides within its amino-terminal 1-185 region.
Elevated baseline plasma levels of PLTP are associated with an increased risk of long-term all-cause mortality in patients with diabetes and known or suspected coronary disease.
This review summarizes the recent progresses made in the PLTP research field and focuses on the complexity of the implication of PLTP in obesity, insulin (show INS ELISA Kits) resistance and type 2 diabetes mellitus. [review]
Elevated plasma PLTP activity may predict an increased risk of T2DM in men
High systemic PLTP expression does not contribute significantly to a renal phenotype despite being implicated in systemic atherosclerosis in ApoE (show APOE ELISA Kits) deficient mice.
proteolytic cleavage of PLTP by cathepsin G (show CTSG ELISA Kits) may enhance the injurious inflammatory responses that occur in COPD (show ARCN1 ELISA Kits)
PLTP is actively involved in lipid transfer, cholesterol efflux, HDL (show HSD11B1 ELISA Kits) genesis, and remodeling at the blood-brain barrier.
Lower plasma CETP (show CETP ELISA Kits) or higher PLTP activity was each associated with a significantly increased risk of cardiovascular disease.
Higher PLTP activity is associated with depressed LV systolic function in a dose-dependent manner.
Data presented a novel model to link phospholipid metabolism to APP (show APP ELISA Kits) processing and also suggested that PLTP played an important role in Abeta (show APP ELISA Kits) metabolism and would be useful to further elucidate functions of PLTP in Alzheimer's disease susceptibility.
In hepatocytes, initial recruitment of phospholipid (PL) by apoB (show APOB ELISA Kits):1000 leading to the formation of the PL-rich apoB (show APOB ELISA Kits)-containing initiation complex is mediated to a large extent by PLTP.
PLTP plays an important role in modulating the stability of atherosclerotic plaques. The receptor-interacting protein 3 (show RIPK3 ELISA Kits)- reactive oxygen species signal pathway could be involved in this PLTP-mediated process.
Adipocyte PLTP plays a small but significant role in plasma PLTP activity and promotes cholesterol efflux from adipose tissues.
PLTP exerts significant effects on apoA-I (show APOA1 ELISA Kits) lipidation and nascent HDL (show HSD11B1 ELISA Kits) biogenesis in hepatocytes by promoting ATP-binding cassette transporter A1 (show ABCA1 ELISA Kits)-mediated lipid efflux and the remodeling of nascent HDL (show HSD11B1 ELISA Kits) particles.
Plasma Sphingosine-1-phosphate contents were decreased by 60.1 % in PLTP knockout mice (PLTP-/-, N = 5) compared with their wild type littermates (WT, N = 5) (151.70 +/- 38.59 vs. 379.32 +/- 59.90 nmol/l, P<0.01).
Therefore we concluded that PLTP deficiency impaired cognition and aggravated AD by enhancing the generation of Abeta (show APP ELISA Kits) in the cortex of old mice.
Cerebrovascular oxidative stress increased in PLTP deficient mice, including increased levels of reactive oxygen species (ROS) and lipid peroxidation marker 4-hydroxy-2-nonenal (HNE) and reduced superoxide dismutase (SOD) activity.
PLTP can play a significant role in the pathophysiology of abdominal aortic aneurysm.
Results suggest that phospholipid transfer protein (PLTP) polymorphisms might be an important genetic influence on economic traits in Hanwoo (Korean cattle).
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.
phospholipid transfer protein
, BPI fold containing family E
, lipid transfer protein II
, plasma phospholipid transfer protein
, PLTP-like protein