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The protein encoded by PSPH belongs to a subfamily of the phosphotransferases. Additionally we are shipping Phosphoserine Phosphatase Antibodies (115) and Phosphoserine Phosphatase Proteins (19) and many more products for this protein.
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PSP, comprises eight exons and seven introns, is strongly expressed in parotid glands, but is not present in heart, liver, lung, kidney, muscle, or stomach.
PSPH expression is a novel biomarker for poor prognosis and could play an important role in tumor progression of colorectal cancer.
We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc (show MYC ELISA Kits)-driven cancer progression both in vitro and in vivo
study of an intellectual disability family from Pakistan; identified a variant in PSPH: chr7:56088803C>T, NM_004577.3 c.103G>A; p.Ala35Thr (hg19) which segregated in homozygous form with the phenotype in both branches of the family
phosphoserine phosphatase deficiency is associated with Neu-Laxova syndrome.
status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation
human phosphoserine phosphatase structure now shows a sevenfold coordinated Ca(2 (show CA2 ELISA Kits)+) ion in the active site that might explain the inhibitory effect of Ca(2 (show CA2 ELISA Kits)+) on the enzyme
PSP has a role in neural stem cell proliferation and may regulate signaling between neural stem cells and other cells within the stem cell niche.
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome.
, parotid secretory protein
, O-phosphoserine phosphohydrolase
, L-3-phosphoserine phosphatase