Piezo-Type Mechanosensitive Ion Channel Component 1 Proteins (PIEZO1)

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. Additionally we are shipping PIEZO1 Antibodies (42) and PIEZO1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIEZO1 9780 Q92508
PIEZO1 234839  
Rat PIEZO1 PIEZO1 361430 Q0KL00
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Top PIEZO1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

PIEZO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Interaction Partners

Human Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) interaction partners

  1. differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II.

  2. data demonstrate that PIEZO1 is required for the regulation of NO formation, vascular tone, and blood pressure.

  3. The Piezo1 convert a variety of mechanical stimuli into channel activation and subsequent inactivation, and what molecules and mechanisms modulate Piezo function.

  4. Because Piezo1 senses both mechanical crowding and stretch, it may act as a homeostatic sensor to control epithelial cell numbers, triggering extrusion and apoptosis in crowded regions and cell division in sparse regions.

  5. platelets and Meg (show PTPN4 Proteins)-01 cells express the MS cation channel (show TRPV1 Proteins) Piezo1, which may contribute to Ca(2 (show CA2 Proteins)+) entry and thrombus formation under arterial shear.

  6. correlation between HPCHA and PIEZO1-gene mutated findings raise an important question as to whether any of the high phosphatidylcholine (show SGMS2 Proteins) hemolytic anemia cases previously diagnosed in Japan may have in fact been the form of hemolytic anemia known as hereditary xerocytosis or dehydrated hereditary stomatocytosis with PIEZO1 gene mutation

  7. Piezo1 responds to lateral membrane tension with exquisite sensitivity as compared to other mechanically activated channels and that resting tension can drive channel inactivation, thereby tuning overall mechanical sensitivity of Piezo1.

  8. Mutations in PIEZO1 is associated with persistent lymphoedema caused by congenital lymphatic dysplasia.

  9. Homozygous and compound heterozygous mutations in PIEZO1, result in an autosomal recessive form of generalized lymphatic dysplasia with a high incidence of non-immune hydrops fetalis and childhood onset of facial and four limb lymphoedema.

  10. Mechanically activated Piezo1 plays an essential role in red blood cell volume homeostasis.

Mouse (Murine) Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) interaction partners

  1. data demonstrate that PIEZO1 is required for the regulation of NO formation, vascular tone, and blood pressure.

  2. Our results suggest that Piezo1 is unlikely to be a component of the mechanoelectrical transducer channel complex in mammalian cochlear outer hair cells

  3. Smooth muscle Piezo1 is required for stretch-activated cationic channel activity. PIezo1 is involved in the remodeling of small arteries.

  4. This study demonstrated that Piezo1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.

  5. Astrocytes in optic nerve head express multiple mechanosensitive channels, in particular Piezo1 and 2. The expression of putative mechanosensitive channels in these cells may contribute to their responsiveness to traumatic or glaucomatous injury.

  6. cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 A

  7. Piezo1 channels as sensors of blood flow was shown by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells and the ability of exogenous Piezo1 to confer sensitivity to shear stress on otherwise resistant cells

  8. Piezo1 is activated by shear stress, the major type of mechanical force experienced by endothelial cells in response to blood flow.

  9. overexpression of Piezo1 or Piezo2 induced 2 kinetically distinct mechanically activated (MA) currents; Piezos are expressed in several tissues; propose that Piezos are components of MA cation channels

PIEZO1 Protein Profile

Protein Summary

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010

Gene names and symbols associated with PIEZO1

  • piezo-type mechanosensitive ion channel component 1 (PIEZO1)
  • piezo-type mechanosensitive ion channel component 1 (Piezo1)
  • 9630020g22 protein
  • DHS protein
  • Fam38a protein
  • Mib protein
  • mKIAA0233 protein

Protein level used designations for PIEZO1

family with sequence similarity 38, member A , membrane protein induced by beta-amyloid treatment , protein PIEZO1

GENE ID SPECIES
9780 Homo sapiens
234839 Mus musculus
361430 Rattus norvegicus
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