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Pigeon Homolog (Drosophila) Proteins (PION)

Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD\; MIM 104300). Additionally we are shipping Pigeon Homolog (Drosophila) Antibodies (44) and Pigeon Homolog (Drosophila) Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PION 54103 A4D1B5
PION 212167 Q3TCV3
Rat PION PION 311984  
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Top Pigeon Homolog (Drosophila) Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$753.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details

PION Proteins by Origin and Source

Origin Expressed in Conjugate
Human
,
Mouse (Murine)

More Proteins for Pigeon Homolog (Drosophila) (PION) Interaction Partners

Human Pigeon Homolog (Drosophila) (PION) interaction partners

  1. GSAP cleavage via caspase-3 (show CASP3 Proteins) is regulated and depend upon the availability of 5-Lipoxygenase (show ALOX5 Proteins) in Alzheimer's disease.

  2. gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation

  3. Protocols for recombinant bacterial expression and purification of potentially important protein GSAP are not successful in generating soluble forms of GSAP that contain well-ordered and homogeneous tertiary structure.

  4. Aberrant regulation of gamma-secretase activating protein expression plays a key role in acceleration of gamma-cleavage of beta-secretase-cleaved C-terminal fragment of amyloid precursor protein (show APP Proteins) and accumulation of Abeta (show APP Proteins) in AD brains

  5. A gamma-secretase activating protein (GSAP) that selectively increases amyloid-beta production via interactions with both gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment.

Mouse (Murine) Pigeon Homolog (Drosophila) (PION) interaction partners

  1. GSAP cleavage via caspase-3 (show CASP3 Proteins) is regulated and depend upon the availability of 5-Lipoxygenase (show ALOX5 Proteins) in Alzheimer's disease.

  2. gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation

  3. Study reports discovery of a novel gamma-secretase activating protein (GSAP) that selectively increases amyloid-beta production through interactions with gamma-secretase and its substrate, the amyloid precursor protein (show APP Proteins) carboxy-terminal fragment.

Pigeon Homolog (Drosophila) (PION) Protein Profile

Protein Summary

Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD\; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1\; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP\; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010

Gene names and symbols associated with PION

  • gamma-secretase activating protein (GSAP)
  • gamma-secretase activating protein (Gsap)
  • A530088I07Rik protein
  • Pion protein

Protein level used designations for PION

gamma-secretase-activating protein , pigeon homolog , protein pigeon homolog

GENE ID SPECIES
54103 Homo sapiens
212167 Mus musculus
311984 Rattus norvegicus
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