Pituitary Homeobox 3 Proteins (PITX3)

PITX3 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Additionally we are shipping Pituitary Homeobox 3 Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PITX3 5309 O75364
PITX3 29609 P81062
PITX3 18742 O35160
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Top Pituitary Homeobox 3 Proteins at antibodies-online.com

Showing 6 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,772.00
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Yeast Mouse His tag   50 μg Log in to see 8 to 11 Days
$341.00
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HOST_Escherichia coli (E. coli) Mouse GST tag   50 μg Log in to see 11 Days
$341.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,803.17
Details

PITX3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

Mouse (Murine) , ,
,

More Proteins for Pituitary Homeobox 3 (PITX3) Interaction Partners

Human Pituitary Homeobox 3 (PITX3) interaction partners

  1. Study showed that PITX3 and PITX2 (show PITX2 Proteins) were hypermethylated in prostate carcinomas (PCa (show FLVCR1 Proteins)) and significantly associated with established clinicopathologic parameters characteristic of PCa (show FLVCR1 Proteins).

  2. These findings suggest that p.A203fs in PITX3 is the cause of cataracts in the recruited family.

  3. PITX3 variants rs3758549 and rs4919621 are not associated with ET in Chinese Han population.

  4. novel PITX3 mutation c.573del, p.(Ser192Alafs*117), was identified in heterozygous state in a Belgo-Romanian family with a similar phenotype

  5. our data demonstrate that key midbrain dopamine regulators (Nurr1 (show NR4A2 Proteins), Pitx3, and Lmx1a (show LMX1A Proteins)) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons

  6. Mutations in PITX3 are not a common cause or a risk factor for multisystem atrophy and progressive supranuclear palsy in the Polish population.

  7. Presence of the rs4919621 allele A in PITX3 significantly increases the risk of Parkinson's disease (PD) patients in a Caucasian population, while rs2281983 allele C and rs4919621 allele A were both risk factors in early onset PD.

  8. This study provided that NURR1 (show NR4A2 Proteins) and PITX3 gene expression is decreased in the peripheral blood lymphocytes of Chinese patients with Parkinson's disease patients.

  9. novel synonymous SNP in PITX3 gene may contribute to PD risk in the Chinese population.

  10. Deletion of PITX3 is associated with aggressive neurobehavioral phenotype in Smith-Magenis Syndrome.

Xenopus laevis Pituitary Homeobox 3 (PITX3) interaction partners

  1. In Xenopus, pitx3 appears to inhibit the rotation of presomitic cell cohorts and to be necessary to the bilaterally symmetric expression of pitx2 (show PITX2 Proteins) in somites.

  2. Microarray-based identification of Pitx3 targets during Xenopus embryogenesis.

  3. expression of Pitx3 in the presumptive lens ectoderm is critical for retina development

Mouse (Murine) Pituitary Homeobox 3 (PITX3) interaction partners

  1. in absence of En1 (show EN1 Proteins) and Pitx3, only a limited number of Mesodiencephalic dopaminergic neurons are present in mouse embryo.

  2. Pitx3 is specifically required for DA-related function and, if impaired, Pitx3 could contribute during the pathogenesis of Parkinson's disease.

  3. the sonic hedgehog (show SHH Proteins) signaling pathway is both necessary and sufficient for the induction of ectopic PITX3 expression in chick mesencephalon downstream of WNT9A (show WNT9A Proteins)-induced LMX1a (show LMX1A Proteins) transcription.

  4. microphthalmos/aphakia inPITX3 nonsense mutant is caused by the expression of truncated PITX3, resulting in the abnormal expression of downstream targets and lens fiber proteins.

  5. Pitx3 binds to an evolutionary conserved bicoid-binding site on the 5'-upstream region of Foxe3 (show FOXE3 Proteins). Pitx3 binding to 5'-upstream region of Foxe3 (show FOXE3 Proteins) increased transcriptional activity significantly in a cell-based reporter assay.

  6. During fetal myogenesis, Pitx2 (show PITX2 Proteins)/3 control this redox state through the regulation of Nrf1 (show NRF1 Proteins) and of antioxidant pathways.

  7. Pitx3 overexpressing mouse significantly affects the gene expression of midbrain dopamine neurons. Motor coordination and locomotion activities are significantly affected in mice overexpressing Pitx3 mice.

  8. Primary fetal neurobehavioral deficit of the Pitx3 mutation is akinesia related to nigrostriatal damage.

  9. Two crucial mediators of mesodiencephalic dopaminergic neuronal development, En1 (show EN1 Proteins) and Pitx3, interact in dopaminergic subset specification.

  10. a novel link between Pitx3 function and the selective pattern of midbrain dopaminergic neurons cell loss observed in Parkinson's disease.

Zebrafish Pituitary Homeobox 3 (PITX3) interaction partners

  1. pitx3 expression in the primordia of the pituitary, lens, olfactory mucosa, and cranial ganglia is modulated by hedgehog (show SHH Proteins) and nodal proteins' signaling.

  2. results demonstrate zebrafish pitx3 represents a true ortholog of the human PITX3 gene and the general function of the Pitx3 protein in lens development is conserved between mammals and the teleost fish

  3. Data demonstrate that Foxe3 (show FOXE3 Proteins) is necessary for lens development in zebrafish and that foxe3 (show FOXE3 Proteins) lies genetically downstream of pitx3 in a zebrafish lens development pathway.

  4. while lmx1b (show LMX1B Proteins) paralogues may contribute to the generation of diencephalic dopaminergic precursors. Conversely, knock-down of pitx3 does not specifically affect any diencephalic dopamine cluster

Pituitary Homeobox 3 (PITX3) Protein Profile

Protein Summary

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.

Gene names and symbols associated with Pituitary Homeobox 3 Proteins (PITX3)

  • paired-like homeodomain 3 (PITX3)
  • paired-like homeodomain 3 (Pitx3)
  • paired-like homeodomain 3 (pitx3)
  • paired-like homeodomain transcription factor 3 (Pitx3)
  • paired-like homeodomain transcription factor 3 (pitx3)
  • paired-like homeodomain transcription factor Pitx3 (pitx3)
  • ak protein
  • CTPP4 protein
  • CTRCT11 protein
  • pitx3 protein
  • pitx3-A protein
  • Ptx3 protein
  • xPitx3 protein
  • zgc:109716 protein

Protein level used designations for Pituitary Homeobox 3 Proteins (PITX3)

pituitary homeobox 3 , homeobox protein PITX3 , paired-like homeodomain transcription factor 3 , homeobox protein PTX3 , homeodomain transcription factor Pitx-3 , Pituitary homeobox 3 (Homeobox protein PITX3) , aphakia , bicoid-like homeodomain transcription factor 3 , bicoid-like homeodomain transcription factor Pitx3 , XPitx-3

GENE ID SPECIES
100422803 Ovis aries
5309 Homo sapiens
486856 Canis lupus familiaris
512000 Bos taurus
29609 Rattus norvegicus
398183 Xenopus laevis
423756 Gallus gallus
18742 Mus musculus
402974 Danio rerio
373824 Xenopus laevis
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