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PIWIL1 encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. Additionally we are shipping Piwi-Like 1 (Drosophila) Antibodies (71) and many more products for this protein.
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piwi plays a generally conserved role in germ cell development in Oryzias latipes.
the zebrafish homologue of the Drosophila piwi: co-localization with vasa (show DDX4 Proteins) at the embryonic genital ridge and gonad-specific expression in the adults (ziwi protein).
Tdrd1 (show TDRD1 Proteins) acts as a molecular scaffold for Ziwi.
Promoter activity of a 4.8-kb sequence isolated from the 5' end of the zebrafish germ cell-specific ziwi gene is sufficient to drive gene expression in all germ cells with stage-specific differences in expression levels.
study demonstrated that zebrafish Piwi, Ziwi is expressed in gonad of both sexes and is a component of a structure called nuage; loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval development
Ziwi and Zili bind piRNAs of opposite polarity
Data show that Piwil1 and Piwil2 are mapped together onto the chromosome 14, at the q14 and q11 respectively.
In blood serum, piR (show PIR Proteins)-823 is up-regulated, but with unsatisfactory analytical performance. Preliminary data indicate the promising diagnostic utility of urinary piR (show PIR Proteins)-823 in patients with RCC (show XRCC1 Proteins)
Overexpression of Hiwi significantly suppressed cell proliferation and cell migration and induced apoptosis in K562 cells.
Hiwi upregulation enhanced chemosensitivity of Chronic Myeloid Leukemia (show BCL11A Proteins) cells to daunomycin, suppressed cell proliferation and promoted apoptosis.
HIWI promotes the activity of breast cancer cells while depression of HIWI may induce apoptosis of breast cancer cells.
Our study reveals a novel mechanism for PIWIL1 in tumorigenesis.
PIWIL1 expression emerged as an independent prognostic marker in non-small cell lung cancer.
Among patients with high let-7a expression, those with medium HIWI had an increased risk of death compared to those with low HIWI (HR = 2.62, 95% CI: 1.30-5.30).
results suggested that Piwil1 caused the loss of PTEN expression through DNMT1-mediated PTEN hypermethylation
Results show that HIWI is highly expressed in high-grade squamous intraepithelial lesions and cervical cancer tissues suggesting its participation in the carcinogenesis of cervical cancer.
Our results indicate a reciprocal regulation between HIWI, HILI and some CSCs markers in colorectal cancer
full-length transcript present in testes, not in oocytes or early embryos; two shorter isoforms, PL1 (show PRL3D1 Proteins)-10 and PL1 (show PRL3D1 Proteins)-13, expressed in oocytes and early embryos
Stem cell protein (show TAL1 Proteins) Piwil1 plays an important role in regulating stem-like properties of endometrial cancer cells.
piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.
PIWIL1 regulates neuronal polarization and radial migration partly via modulating the expression of microtubule-associated proteins.
We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.
Mice with a global deletion of all three piwi genes, Miwi, Mili, and Miwi2 (show PIWIL4 Proteins), are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.
Miwi protein might be an important functional protein in murine folliculogenesis
The in vitro studies show estrogen can downregulate the expression of miwi and mili.
characterize the genome-wide target RNA repertoire of Mili (Piwil2) and Miwi (Piwil1), two Piwi proteins expressed in postnatal testis
This work identifies an epigenetic regulation mechanism for the spatio-temporal expression of mouse Miwi during spermatogenesis.
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
piwi-like 1 (Drosophila)
, PIWI-like protein 1
, argonaut-like protein
, piwi-like protein 1
, piwi homolog
, piwi-like 1
, piwi-like protein 1-like
, piwi like homolog 1
, piwi-like homolog 1