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Piwi-Like 1 (Drosophila) Proteins (PIWIL1)

PIWIL1 encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. Additionally we are shipping Piwi-Like 1 (Drosophila) Antibodies (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIWIL1 9271 Q96J94
PIWIL1 57749 Q9JMB7
Rat PIWIL1 PIWIL1 363912  
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Top Piwi-Like 1 (Drosophila) Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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PIWIL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Piwi-Like 1 (Drosophila) (PIWIL1) Interaction Partners

Medaka Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. piwi plays a generally conserved role in germ cell development in Oryzias latipes.

Zebrafish Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. the zebrafish homologue of the Drosophila piwi: co-localization with vasa (show DDX4 Proteins) at the embryonic genital ridge and gonad-specific expression in the adults (ziwi protein).

  2. Tdrd1 (show TDRD1 Proteins) acts as a molecular scaffold for Ziwi.

  3. Promoter activity of a 4.8-kb sequence isolated from the 5' end of the zebrafish germ cell-specific ziwi gene is sufficient to drive gene expression in all germ cells with stage-specific differences in expression levels.

  4. study demonstrated that zebrafish Piwi, Ziwi is expressed in gonad of both sexes and is a component of a structure called nuage; loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval development

  5. Ziwi and Zili bind piRNAs of opposite polarity

Pig (Porcine) Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. Data show that Piwil1 and Piwil2 are mapped together onto the chromosome 14, at the q14 and q11 respectively.

Human Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. In blood serum, piR (show PIR Proteins)-823 is up-regulated, but with unsatisfactory analytical performance. Preliminary data indicate the promising diagnostic utility of urinary piR (show PIR Proteins)-823 in patients with RCC (show XRCC1 Proteins)

  2. Overexpression of Hiwi significantly suppressed cell proliferation and cell migration and induced apoptosis in K562 cells.

  3. Hiwi upregulation enhanced chemosensitivity of Chronic Myeloid Leukemia (show BCL11A Proteins) cells to daunomycin, suppressed cell proliferation and promoted apoptosis.

  4. HIWI promotes the activity of breast cancer cells while depression of HIWI may induce apoptosis of breast cancer cells.

  5. Our study reveals a novel mechanism for PIWIL1 in tumorigenesis.

  6. PIWIL1 expression emerged as an independent prognostic marker in non-small cell lung cancer.

  7. Among patients with high let-7a expression, those with medium HIWI had an increased risk of death compared to those with low HIWI (HR = 2.62, 95% CI: 1.30-5.30).

  8. results suggested that Piwil1 caused the loss of PTEN expression through DNMT1-mediated PTEN hypermethylation

  9. Results show that HIWI is highly expressed in high-grade squamous intraepithelial lesions and cervical cancer tissues suggesting its participation in the carcinogenesis of cervical cancer.

  10. Our results indicate a reciprocal regulation between HIWI, HILI and some CSCs markers in colorectal cancer

Cow (Bovine) Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. full-length transcript present in testes, not in oocytes or early embryos; two shorter isoforms, PL1 (show PRL3D1 Proteins)-10 and PL1 (show PRL3D1 Proteins)-13, expressed in oocytes and early embryos

Mouse (Murine) Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. Stem cell protein (show TAL1 Proteins) Piwil1 plays an important role in regulating stem-like properties of endometrial cancer cells.

  2. piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.

  3. PIWIL1 regulates neuronal polarization and radial migration partly via modulating the expression of microtubule-associated proteins.

  4. Results show that HIWI is highly expressed in high-grade squamous intraepithelial lesions and cervical cancer tissues suggesting its participation in the carcinogenesis of cervical cancer.

  5. We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  6. Mice with a global deletion of all three piwi genes, Miwi, Mili, and Miwi2 (show PIWIL4 Proteins), are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.

  7. Miwi protein might be an important functional protein in murine folliculogenesis

  8. The in vitro studies show estrogen can downregulate the expression of miwi and mili.

  9. characterize the genome-wide target RNA repertoire of Mili (Piwil2) and Miwi (Piwil1), two Piwi proteins expressed in postnatal testis

  10. This work identifies an epigenetic regulation mechanism for the spatio-temporal expression of mouse Miwi during spermatogenesis.

Piwi-Like 1 (Drosophila) (PIWIL1) Protein Profile

Protein Summary

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PIWIL1

  • piwi-like 1 (Drosophila) (PIWIL1)
  • PIWI-like protein 1 (Tb10.70.5520)
  • PIWI-like protein 1 (LinJ21.0310)
  • PIWI-like protein 1 (LbrM21_V2.0470)
  • piwi-like protein 1 (LOC100301587)
  • piwi-like 1 (Drosophila) (piwil1)
  • piwi-like RNA-mediated gene silencing 1 (PIWIL1)
  • piwi-like RNA-mediated gene silencing 1 (Piwil1)
  • HIWI protein
  • MIWI protein
  • PIWI protein
  • ziwi protein

Protein level used designations for PIWIL1

piwi-like 1 (Drosophila) , PIWI-like protein 1 , argonaut-like protein , piwi-like protein 1 , piwi homolog , piwi-like 1 , piwi-like protein 1-like , piwi like homolog 1 , piwi-like homolog 1

GENE ID SPECIES
452369 Pan troglodytes
3662385 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5068770 Leishmania infantum JPCM5
5415312 Leishmania braziliensis MHOM/BR/75/M2904
100301587 Oryzias latipes
368200 Danio rerio
477440 Canis lupus familiaris
100499508 Sus scrofa
416804 Gallus gallus
9271 Homo sapiens
537833 Bos taurus
57749 Mus musculus
363912 Rattus norvegicus
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