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Plakophilin 4 Proteins (PKP4)

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. Additionally we are shipping Plakophilin 4 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PKP4 8502 Q99569
PKP4 227937 Q68FH0
Rat PKP4 PKP4 295625  
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Top Plakophilin 4 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

PKP4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Plakophilin 4 (PKP4) Interaction Partners

Human Plakophilin 4 (PKP4) interaction partners

  1. p0071 has a key role in regulating recycling through the Rab11a (show RAB11A Proteins)-dependent perinuclear recycling compartment.

  2. This review article focuses on the functions of the p0071 protein and its closest relatives in regulating cell adhesion and cytoskeletal organization, which are critically involved in the control of cell polarity. [review]

  3. Findings suggest that aspects of folliculin (show FLCN Proteins) tumour suppressor function are linked to interaction with p0071 and the regulation of RhoA (show RHOA Proteins) signalling.

  4. These data support a model in which dysregulation of the FLCN (show FLCN Proteins)-p0071 interaction leads to alterations in cell adhesion, cell polarity, and RhoA (show RHOA Proteins) signaling.

  5. The structural and functional roles of p0071 are suggested by its preferential occurrence in distinct tubule segments, and its potential use as a cytodiagnostic cell type marker in renal pathology is discussed.

  6. ERBIN (show ERBB2IP Proteins) interacts in vivo with p0071 and that it may be involved in the organization of adherens junctions and the desmosomes of epithelia

  7. In addition to plakoglobin (show JUP Proteins), p0071 is the second armadillo (show PKP1 Proteins) protein present in both types of adhesive junctions and may play a role in regulating crosstalk between adherens junctions and desmosomes.

  8. p0071 bound to the first 160 amino-terminal residues of desmoplakin and also interacted directly with plakoglobin (show JUP Proteins), suggesting that p0071 may regulate desmosome assembly by controlling plakoglobin (show JUP Proteins) availability

  9. These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis.

  10. In this review p0071 catenin, a close relative of p120 catenin (show CTNND1 Proteins), associates and regulates RhoA-GTPase at the cleavage furrow during cytokinesis.

Mouse (Murine) Plakophilin 4 (PKP4) interaction partners

  1. results identify p0071 as an important and novel FMRP (show FMR1 Proteins) target and strongly suggest that impaired actin cytoskeletal functions mediated by an excess of p0071 are key aspects underlying the fragile X (show FMR1 Proteins) syndrome

  2. These data support a model in which dysregulation of the FLCN (show FLCN Proteins)-p0071 interaction leads to alterations in cell adhesion, cell polarity, and RhoA (show RHOA Proteins) signaling.

Plakophilin 4 (PKP4) Protein Profile

Protein Summary

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms.

Gene names and symbols associated with Plakophilin 4 Proteins (PKP4)

  • plakophilin 4 (PKP4)
  • plakophilin 4 (pkp4)
  • plakophilin 4 (Pkp4)
  • 5031422I09Rik protein
  • 9430019K17Rik protein
  • Armrp protein
  • CTNND2 protein
  • MGC146695 protein
  • p0071 protein
  • PKP4 protein

Protein level used designations for Plakophilin 4 Proteins (PKP4)

plakophilin 4 , catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) , catenin 4 , plakophilin-4 , armadillo-related protein

GENE ID SPECIES
424328 Gallus gallus
459676 Pan troglodytes
478759 Canis lupus familiaris
527732 Bos taurus
780351 Xenopus (Silurana) tropicalis
100050975 Equus caballus
100546711 Meleagris gallopavo
100561325 Anolis carolinensis
8502 Homo sapiens
281406 Bos taurus
227937 Mus musculus
295625 Rattus norvegicus
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