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Plasminogen Activator, Urokinase Receptor Proteins (PLAUR)

PLAUR encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. Additionally we are shipping PLAUR Antibodies (137) and PLAUR Kits (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLAUR 18793 P35456
PLAUR 5329 Q03405
PLAUR 50692 P49616
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Top PLAUR Proteins at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag,Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_HEK-293 Cells Human His tag 200 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$114.15
Details
HOST_HEK-293 Human His tag 100 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Mouse HIS-GST 100 μg Log in to see 11 to 13 Days
$844.80
Details

PLAUR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
, ,
Human , , , , , ,
,
Rat (Rattus)

Top referenced PLAUR Proteins

  1. Human PLAUR Protein expressed in HEK-293 - ABIN2666525 : Vincenza Carriero, Franco, Vocca, Alfano, Longanesi-Cattani, Bifulco, Mancini, Caputi, Stoppelli: Structure, function and antagonists of urokinase-type plasminogen activator. in Frontiers in bioscience (Landmark edition) 2009 (PubMed)
    Show all 8 references for ABIN2666525

  2. Human PLAUR Protein expressed in HEK-293 Cells - ABIN2181889 : Huai, Mazar, Kuo, Parry, Shaw, Callahan, Li, Yuan, Bian, Chen, Furie, Furie, Cines, Huang: Structure of human urokinase plasminogen activator in complex with its receptor. in Science (New York, N.Y.) 2006 (PubMed)
    Show all 4 references for ABIN2181889

  3. Mouse (Murine) PLAUR Protein expressed in Human Cells - ABIN2007425 : Dear, Medcalf: The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule. in European journal of biochemistry / FEBS 1998 (PubMed)
    Show all 3 references for ABIN2007425

  4. Mouse (Murine) PLAUR Protein expressed in Human Cells - ABIN2007428 : Suh, Nerlov, Danø, Degen: The murine urokinase-type plasminogen activator receptor gene. in The Journal of biological chemistry 1994 (PubMed)
    Show all 2 references for ABIN2007428

More Proteins for Plasminogen Activator, Urokinase Receptor (PLAUR) Interaction Partners

Mouse (Murine) Plasminogen Activator, Urokinase Receptor (PLAUR) interaction partners

  1. Significance of the urokinase-type plasminogen activator (show PLAU Proteins) and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.

  2. Findings indicate a significant correlation of uPAR cleavage with breast cancer progression, but the precise biological consequence(s) of the cleavage or the cleavage products still remains to be elucidated.

  3. interaction of full-length suPAR with alphavbeta3 integrin expressed on podocytes results in down-modulation of nephrin (show NPHS1 Proteins) that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR.

  4. In an (show EPHA3 Proteins)in vivo murine angiogenesis model uPAR-deficient PTEN heterozygous animals increased the impaired angiogeni (show AKT1 Proteins)c phenotype of uPAR knockout mice and were able to reverse the high invasive potential of PTEN heterozygotes.

  5. uPAR contributes to macrophage driven atherosclerotic lesion formation.

  6. we have firstly shown a fundamental mechanism of urokinase system(uPa (show PLAU Proteins) and uPAR)-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.

  7. our data show that uPAR is required for efficient skin tumor formation

  8. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.

  9. deficiency of uPAR and PSMD6 (show PSMD6 Proteins) delays DNA repair and leads to decreased cell survival.

  10. beta-elemene downregulates expression of uPA (show PLAU Proteins), uPAR, MMP-2 (show MMP2 Proteins), and MMP-9 (show MMP9 Proteins) in a murine intraocular melanoma model

Human Plasminogen Activator, Urokinase Receptor (PLAUR) interaction partners

  1. Hypoxia enhanced the endogenous uPAR mRNA and protein expression.HIF-1 protein bound the putative HIF-1 (show HIF1A Proteins) response element on the uPAR promoter.uPAR protein expression was detected in cervical cancer but not in normal cervix or CIN (show PDXP Proteins).

  2. Significance of the urokinase-type plasminogen activator (show PLAU Proteins) and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.

  3. uPAR/suPAR is elevated in most kidney diseases.

  4. The present paper develops a mathematical model of cancer recurrence besed on UPAR serum concentration.

  5. uPAR-VEGFR2 interaction is crucial for VEGF signaling in endothelial cells

  6. Human uPAR activation and its association with beta1-integrin are required for PDGF (show PDGFA Proteins)-AB-induced migration.

  7. Both the depressed patients and suicide attempters had increased plasma soluble form of the urokinase receptor (suPAR). The levels of suPAR discriminated better between controls and suicide attempters than did C reactive protein (show CRP Proteins).

  8. In HEK (show EPHA3 Proteins) 293 cells, transfected with human uPAR, uPAR overexpression down-regulates PTEN and activates the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)-pathway.

  9. Results found high levels of uPA (show PRAP1 Proteins) and uPAR exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA (show PRAP1 Proteins)/uPAR axis in an autocrine and paracrine fashion.

  10. In patients with IgA nephropathy, the plasma suPAR levels were associated with age, gender, renal function, the degree of tubular atrophy/interstitial fibrosis and the percentage of crescent (show SFRP5 Proteins) formation.

Cow (Bovine) Plasminogen Activator, Urokinase Receptor (PLAUR) interaction partners

  1. uPA (show PLAU Proteins)/uPAR binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.

  2. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

  3. These data indicated that E. coli LPS (show IRF6 Proteins) led to an increase in u-PA (show PLAU Proteins) activity and RNA expression of u-PA (show PLAU Proteins) and u-PAR in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.

  4. the interaction between uPAR and Man-6-P/IGF2R (show IGF2R Proteins) is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R (show IGF2R Proteins) by different mechanisms.

PLAUR Protein Profile

Protein Summary

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

Gene names and symbols associated with PLAUR

  • plasminogen activator, urokinase receptor (PLAUR)
  • plasminogen activator, urokinase receptor (Plaur)
  • urokinase-type plasminogen activator receptor (LOC100101584)
  • CD87 protein
  • Par protein
  • PLAUR protein
  • Plaur3 protein
  • U-PAR protein
  • UPAR protein
  • uPAR-2 protein
  • uPAR-3 protein
  • URKR protein

Protein level used designations for PLAUR

urokinase plasminogen activator surface receptor , plasminogen activator, urokinase receptor , urokinase plasminogen activator receptor , urokinase-type plasminogen activator receptor , monocyte activation antigen Mo3 , u-plasminogen activator receptor form 2 , urokinase-type plasminogen activator (uPA) receptor , U-PAR , uPAR , plasminogen activator urokinase receptor 3 , urinary plasminogen activator receptor 2 , urinary plasminogen activator receptor 3

GENE ID SPECIES
100033904 Equus caballus
100302564 Ovis aries
18793 Mus musculus
5329 Homo sapiens
476446 Canis lupus familiaris
281983 Bos taurus
50692 Rattus norvegicus
450103 Pan troglodytes
100101584 Oryctolagus cuniculus
Selected quality suppliers for PLAUR Proteins (PLAUR)
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