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Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Additionally we are shipping PLEKHG6 Proteins (4) and many more products for this protein.
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Human Polyclonal PLEKHG6 Primary Antibody for EIA, WB - ABIN453207
DAngelo, Aresta, Blangy, Del Maestro, Louvard, Arpin: Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. in Molecular biology of the cell 2007
Intramolecular interactions between MyoGEF domains act as an autoinhibitory mechanism for the regulation of MyoGEF functions.
Taken together, these results suggest that aurora B (show AURKB Antibodies) coordinates with Plk1 (show PLK1 Antibodies) to regulate MyoGEF activation and localization, thus contributing to the regulation of cytokinesis.
GIPC1 (show GIPC1 Antibodies)-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.
ezrin (show EZR Antibodies) allows the local activation of RhoG (show RHOG Antibodies) at the apical pole of epithelial cells by recruiting upstream and downstream regulators of RhoG (show RHOG Antibodies) and that both PLEKHG6 and ezrin (show EZR Antibodies) are required for efficient macropinocytosis
Plk1 (show PLK1 Antibodies) can regulate MyoGEF activity and localization, contributing to the regulation of cytokinesis
MyoGEF cooperates with nonmuscle myosin IIA to regulate the polarity and invasion activity of breast cancer cells through activation of RhoA (show RHOA Antibodies) and RhoC (show RHOC Antibodies).
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
PH domain-containing family G member 6
, myosin interacting guanine nucleotide exchange factor
, myosin-interacting guanine nucleotide exchange factor
, pleckstrin homology domain-containing family G member 6