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Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Additionally we are shipping Pleckstrin Homology Domain Containing, Family O Member 1 Antibodies (50) and Pleckstrin Homology Domain Containing, Family O Member 1 Proteins (7) and many more products for this protein.
Showing 6 out of 9 products:
the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.
High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.
New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL (show RTEL1 ELISA Kits)) and targeting CKIP-1 may be a novel therapeutic target for NHL (show RTEL1 ELISA Kits).
There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (show PAK1 ELISA Kits) for neoplastic prostate cells transformation.
CKIP-1 interacts with CARMA1 (show CARD11 ELISA Kits) and has an inhibitory effect on PKCtheta (show PRKCQ ELISA Kits);-CBM-NF-kappaB (show NFKB1 ELISA Kits) signaling.
CKIP-1 controlled Smurf1 (show SMURF1 ELISA Kits) expression in colon cancer
overexpression triggers classical monocyte activation and transactivation of the TNF (show TNF ELISA Kits) promoter
CKIP-1, through its leucine zipper, interacts with the Rpt6 and mediates the Smurf1 (show SMURF1 ELISA Kits)-Rpt6 interaction.
CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation--REVIEW
The N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its subcellular localization and the nucleus-plasma membrane shuttling.
The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (show MAPK8 ELISA Kits) phosphorylation and further upregulating IRS-1 (show IRS1 ELISA Kits) phosphorylation and RI.
Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (show ICAM1 ELISA Kits)) and fibronectin (show FN1 ELISA Kits) plus activation of Nrf2 (show NFE2L2 ELISA Kits)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.
the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis
CKIP-1 is a novel inhibitor of MSC (show MSC ELISA Kits)-originated adipogenesis by enhancing HDAC1 (show HDAC1 ELISA Kits)-associated repression of C/EBPalpha (show CEBPA ELISA Kits).
CKIP-1 interacts with TRAF6 (show TRAF6 ELISA Kits), a ubiquitin ligase (show RNF123 ELISA Kits) required for K63-linked ubiquitination and plasma membrane recruitment of Akt (show AKT1 ELISA Kits), and terminates TRAF6 (show TRAF6 ELISA Kits)-mediated Akt (show AKT1 ELISA Kits) activation.
Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.
CKIP-1 was found to be an inhibitor of cardiac hypertrophy by upregulating the dephosphorylation of HDAC4 through the recruitment of protein phosphatase 2A.
CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein (show TMOD4 ELISA Kits)
CKIP-1 functions as the first auxiliary factor to enhance the activation of Smurf1 (show SMURF1 ELISA Kits).
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).
pleckstrin homology domain containing, family O member 1
, C-Jun-binding protein
, CK2 interacting protein 1; HQ0024c protein
, CK2-interacting protein 1
, PH domain-containing family O member 1
, casein kinase 2-interacting protein 1
, osteoclast maturation-associated gene 120 protein
, pleckstrin homology domain-containing family O member 1
, CK2 interacting protein 1
, Jun zipper-associated 2
, TNF intracellular domain-interacting protein