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anti-Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) Antibodies

PABPCP2 encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails.

list all antibodies Gene Name GeneID
PABPCP2 728773
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Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western Blot analysis of PABPCP2 expression in transfected 293T cell line by PABPCP2 MaxPab polyclonal antibody.Lane 1: PABPCP2 transfected lysate(29.59 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
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PABPCP2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human


More Antibodies against Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 Interaction Partners

Human Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) interaction partners

  1. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (show PABPN1 Antibodies) and the poly(A)-specific RNase PARN (show PARN Antibodies).

  2. Many ribozymes were assayed and validated, including four ribozymes targeting the transcript of a disease-causing gene (a mutant version of PABPN1 (show PABPN1 Antibodies)).

  3. Studied if the stability of the RNP (show RNPC3 Antibodies) domain of PABPN1 (show PABPN1 Antibodies) or domain swapping within the RNP (show RNPC3 Antibodies) domain may add to fibril formation.

  4. This function is mediated by the concerted actions of the nuclear poly(A) binding protein PABPN1 (show PABPN1 Antibodies), poly(A) polymerase (PAP (show PAPOLA Antibodies)), and the nuclear exosome complex, a pathway we have named PABPN1 (show PABPN1 Antibodies) and PAP (show REG3A Antibodies)-mediated RNA decay (PPD (show HPD Antibodies))

  5. These findings demonstrate a role for PABPN1 (show PABPN1 Antibodies) in rescuing several cytopathological features of TDP-43 (show TARDBP Antibodies) proteinopathy by increasing the turnover of pathologic proteins.

  6. PABPN1 (show PABPN1 Antibodies) inhibits expression of transcripts with pAs (show PASK Antibodies) near the transcription start site (TSS (show RPL38 Antibodies)), a property possibly related to its role in RNA degradation

  7. this study provided a systematic phosphorylation analysis of the Fanconi anemia protein (show FANCF Antibodies) PALB2 (show PALB2 Antibodies), and have revealed important roles of PALB2 (show PALB2 Antibodies) Ser (show SIGLEC1 Antibodies)-157 and Ser (show SIGLEC1 Antibodies)-376 in driving cellular responses to genotoxic stress.

  8. the first step of the cleavage and polyadenylation reaction, mRNA cleavage, is affected in muscles expressing alanine-expanded PABPN1 (show PABPN1 Antibodies). We propose that impaired cleavage is an early defect in Oculopharyngeal muscular dystrophy.

  9. Data indicate that intron 6 of the poly(A)-binding protein nuclear 1 (PABPN1 (show PABPN1 Antibodies)) gene is required for autoregulation.

  10. The ability of PABPN1 (show PABPN1 Antibodies) to promote splicing requires its RNA binding and, to a lesser extent, poly(A)polymerase (PAP (show PAPOLA Antibodies)) - stimulatory functions.

Poly(A) Binding Protein, Cytoplasmic, Pseudogene 2 (PABPCP2) Antigen Profile

Protein Summary

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Gene names and symbols associated with PABPCP2

  • poly(A) binding protein, cytoplasmic 1 pseudogene 2 (PABPC1P2) antibody
  • poly(A) binding protein, nuclear 1 (PABPN1) antibody
  • OPMD antibody
  • PAB2 antibody
  • PABII antibody
  • PABP-2 antibody
  • PABP2 antibody
  • PABP4 antibody
  • PABPCP2 antibody
  • PABPCP4 antibody

Protein level used designations for PABPCP2

poly(A) binding protein 2 , poly(A) binding protein II , polyadenylate-binding protein 2

GENE ID SPECIES
728773 Homo sapiens
8106 Homo sapiens
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