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This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. Additionally we are shipping PCBP1 Antibodies (108) and PCBP1 Kits (4) and many more products for this protein.
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Human PCBP1 Protein expressed in Escherichia coli (E. coli) - ABIN2004447
Huo, Shen, Ju, Zou, Yan, Brown, Zhong: Identification of novel partner proteins of PCBP1. in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2009
These results establish the role of hnRNP K and PCPB1 in the translational control of morphine-induced MOR expression in human neuroblastoma (NMB) cells as well as cells stably expressing MOR (NMB1).
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1 (show TIA1 Proteins), Pcbp1, and RBM39 (show RBM39 Proteins) stabilizes or increases U2 snRNP (show LSM2 Proteins) recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39 (show RBM39 Proteins)-mediated splicing regulation.
BC200 RNA interacts with hnRNP E1 and E2 mainly through its unique 3' C-rich domain.
Low expression of PCBP1 is associated with lung cancer metastasis.
We found a C-rich element (CRE) in mu-opioid receptor (MOR (show OPRM1 Proteins)) 3'-untranslated region (UTR) to which poly (rC) binding protein 1 (PCBP1) binds, resulting in MOR (show OPRM1 Proteins) mRNA stabilization. AUF1 (show HNRNPD Proteins) phosphorylation also led to an increased interaction with PCBP1.
miR (show MLXIP Proteins)-7977 in extracellular vesicles may be a critical factor that induces failure of normal hematopoiesis via poly(rC) binding protein 1 suppression in myeloid neoplasms.
Poly C binding protein 1 represses autophagy through downregulation of LC3B (show MAP1LC3B Proteins) to promote tumor cell apoptosis in starvation
Inhibin betaA is translationally regulated by TGFbeta (show TGFB1 Proteins) via hnRNP E1.
Suggest that PCBP1 might play an important role in preventing the process of epithelial mesenchymal transformation in NSCLC.
PCBP1 mutations are recurrent in Burkitt lymphomas and might contribute, in cooperation with other mutations, to its pathogenesis.
These data reveal that Pcbp1 and Pcbp2 (show PCBP2 Proteins) are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
PCBP1 may serve as a novel maternal factor (show ZAR1 Proteins).
Our analysis of PCBP1 and PCBP2 (show PCBP2 Proteins) expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.
knockdown of PCBP1 led to a reversal effect on the transcriptional inactivation during oocyte growth, which highlights the important role of PCBP1 in maintaining the gobal transcriptional silencing when the growth phase is completed
TGF-beta (show TGFB1 Proteins) modulates the expression of Dab2 (show DAB2 Proteins) and ILEI (show FAM3C Proteins) mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT (show BAAT Proteins) element in the 3'UTR of Dab2 (show DAB2 Proteins) and ILEI (show FAM3C Proteins).
To define the mechanism of STAT3C suppression of transcript. and/or translational activity of NF-kappaB (show NFKB1 Proteins) we found that a alphaCP-1 interacted with STAT3C. alphaCP-1 is a K-homol. domain-containing RNA-binding prot (show SLC6A7 Proteins) with specific for C-rich pyrimidine tracts
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
poly(rC) binding protein 1
, poly(rC)-binding protein 1-like
, heterogeneous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein X
, nucleic acid-binding protein SUB2.3
, poly(rC)-binding protein 1
, hnRNP-E1 protein
, hnRNP E1