Poly A Specific Ribonuclease Proteins (PARN)

The protein encoded by PARN is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. Additionally we are shipping PARN Antibodies (66) and PARN Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PARN 5073 O95453
Rat PARN PARN 360464  
PARN 74108 Q8VDG3
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Top PARN Proteins at antibodies-online.com

Showing 8 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$341.00
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
Details
HOST_Insect cells (Sf9) Human His tag   1 mg Log in to see 2 to 3 Days
$4,339.50
Details
HOST_Escherichia coli (E. coli) Human GST tag,S tag,His tag   100 μg Log in to see 15 to 18 Days
$656.00
Details

PARN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine)

More Proteins for Poly A Specific Ribonuclease (PARN) Interaction Partners

Human Poly A Specific Ribonuclease (PARN) interaction partners

  1. provide evidence that PARN can also deadenylate the U6 and RMRP (show NME1 Proteins) RNAs without affecting their levels

  2. poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S pre-rRNA maturation in human cells

  3. we found a polyadenylation-dependent 3' end maturation pathway for the human telomerase RNA that relies on the nuclear poly(A)-binding protein PABPN1 (show PABPN1 Proteins) and the poly(A)-specific RNase PARN.

  4. PARN increased telomerase RNA component levels by deadenylating telomerase RNA component, thereby limiting its degradation by EXOSC10 (show EXOSC10 Proteins).

  5. Large monoallelic mutations of PARN can cause developmental/mental illness. Biallelic PARN mutations cause severe bone marrow failure and central hypomyelination.

  6. results highlight the clinical significance of PARN and NOC on the survival in SCC (show CYP11A1 Proteins) diagnosed patients.

  7. Mutations in the PARN gene cause dyskeratosis congenital.

  8. The results indicate that the cellular level of miR (show MLXIP Proteins)-122 is determined by the balance between the opposing effects of GLD-2 (show PAPD4 Proteins) and PARN/CUGBP1 (show CELF1 Proteins) on the metabolism of its 3'-terminus.

  9. 3 families with dyskeratosis congenita had key domain mutations in PARN shortening telomeres, reducing deadenylation, and downregulating TERC, DKC1 (show DKC1 Proteins), RTEL1, and TERF1 (show TERF1 Proteins).

  10. PARN and RTEL1 mutation carriers had shortened leukocyte telomere lengths.

Mouse (Murine) Poly A Specific Ribonuclease (PARN) interaction partners

  1. these data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement.

  2. poly(A) polymerase (show PAPOLA Proteins) Gld2 (show PAPD4 Proteins), deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd (show NGDN Proteins)) are components of a dendritic CPEB (show CPEB1 Proteins)-associated polyadenylation apparatus

  3. Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode.

  4. A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site.

PARN Protein Profile

Protein Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PARN

  • poly(A)-specific ribonuclease (parn)
  • poly(A)-specific ribonuclease (PARN)
  • poly(A)-specific ribonuclease (Parn)
  • poly(A)-specific ribonuclease (deadenylation nuclease) (parn)
  • poly(A)-specific ribonuclease (deadenylation nuclease) (Parn)
  • 1200003I18Rik protein
  • DAN protein
  • parn-A protein
  • RGD1565449 protein
  • xparn protein
  • zgc:56067 protein

Protein level used designations for PARN

deadenylating nuclease , deadenylation nuclease , poly(A)-specific ribonuclease (deadenylation nuclease) , poly(A)-specific ribonuclease PARN , polyadenylate-specific ribonuclease

GENE ID SPECIES
394409 Xenopus laevis
5073 Homo sapiens
479839 Canis lupus familiaris
524155 Bos taurus
360464 Rattus norvegicus
100172259 Pongo abelii
791461 Danio rerio
74108 Mus musculus
Selected quality suppliers for PARN Proteins (PARN)
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