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PTRF encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. Additionally we are shipping Polymerase I and Transcript Release Factor Proteins (6) and Polymerase I and Transcript Release Factor Kits (4) and many more products for this protein.
Showing 10 out of 51 products:
Human Polyclonal PTRF Primary Antibody for EIA, WB - ABIN359583
Aboulaich, Ortegren, Vener, Strålfors: Association and insulin regulated translocation of hormone-sensitive lipase with PTRF. in Biochemical and biophysical research communications 2006
Show all 3 references for ABIN359583
Human Polyclonal PTRF Primary Antibody for EIA, IHC (p) - ABIN359582
Hasegawa, Takeuchi, Miyaishi, Xiao, Mao, Isobe: PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters. in The Biochemical journal 2000
Show all 3 references for ABIN359582
Human Monoclonal PTRF Primary Antibody for IHC (p), ELISA - ABIN567012
Hansen, Bright, Howard, Nichols: SDPR induces membrane curvature and functions in the formation of caveolae. in Nature cell biology 2009
Cow (Bovine) Polyclonal PTRF Primary Antibody for IHC, WB - ABIN2779886
Miyoshi, Cui, Riedlinger, Robinson, Lehoczky, Zon, Oka, Dewar, Hennighausen: Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. in Genomics 2001
Human Polyclonal PTRF Primary Antibody for IHC (p), WB - ABIN391621
Park, Yamaura, Kawamoto, Kurihara, Sato: Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. in PLoS ONE 2014
This study reports an unanticipated function of ROR1 (show ROR1 Antibodies) as a scaffold of cavin-1 and caveolin-1 (show CAV1 Antibodies), two essential structural components of caveolae.
Cavin-1 and cavin-2 (show SDPR Antibodies) are strongly expressed within caveolae-like structures within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver and cavin-1 would play a critical role in regulating aspects of caveolin-1 (show CAV1 Antibodies).
Rather than forming a single coat complex containing the three cavin family members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, cavin2 (show SDPR Antibodies) and cavin3 (show PRKCDBP Antibodies).
Our data support a role for PTRF/cavin-1, through caveolae formation, as an attenuator of the non-caveolar functionality of Cav1 (show CAV1 Antibodies) in Gal3 (show LGALS3 Antibodies)-Cav1 (show CAV1 Antibodies) signalling and regulation of focal adhesion dynamics and cancer cell migration.
this study presents a novel mutation of PTRF from Saudi Arabia and our findings broaden the mutation spectrum of PTRF in the familial CGL4 phenotype.
cavin3 (show PRKCDBP Antibodies) is recruited to the caveolae coat by cavin1 to interact with caveolin1 and regulate the duration time of caveolae at the plasma membrane.
The presence of caveolae as an anatomic structure is not sufficient to ensure their proper function in patient with PTRF mutation.
Using in silico and in vitro analysis we show that Cavin-1 is expressed in myogenic Rhabdomyosarcoma tumors and human and primary mouse RMS cultures. Cavin-1 or Cav-1 (show CAV1 Antibodies) knockdown led to impairment of cell proliferation and migration.
PTRF acts as a modulator in GBM chemoresistance
In human adipose tissue, P (show C9orf3 Antibodies)TRF mRNA levels positively correlated with markers of lipolysis and cellular senescence. A negative relationship between telomere length and PTRF mRNA levels was observed in human subcutaneous fat.
these results suggested that the membrane dynamics in cell migration is affected by caveolae associated PTRF/cavin-1.
study demonstrates a critical role of cavin-1 in vascular structure and function, but the influences on arterial resistance cancel each other such that arterial blood pressure remains unaltered in homeostatic conditions
lipid mobilization in cultured adipocytes to induce lipid droplet shrinkage led to biphasic response of cavin-1 with ultimate loss of expression of cavin-1 by protein degradation.
A Western-type diet in apo (show C9orf3 Antibodies)-E2 knock-in mice produced 3 groups of obese mice with PTRF expression correlating with glucose tolerance: normal, hyperinsulinemic glucose-tolerant, or impaired. PTRF compromised adipocyte differentiation of 3T3-L1 cells.
Adipocytes from cavin-1-null mice are markedly dysfunctional exhibiting decreased insulin (show INS Antibodies)-dependent glucose uptake, fatty acid uptake, and lipolysis.
PTRF is a crucial regulator of TLR4 (show TLR4 Antibodies) signaling in the development of sepsis.
an important role for Cavin1 in lung homeostasis
Cavin-1 is critical for detrusor caveolae and for overall contractility and structure of the urinary bladder.
Cavin-1 modulates cellular polarization, and the subcellular localization of Rac1 and caveolin-1 (show CAV1 Antibodies) in migrating cells as well as PKCalpha (show PKCa Antibodies) caveola recruitment.
Double-immunogold labeling showed that the caveolae-shaping molecule PTRF/cavin 1 behaved similarly and that syndapin II (show PACSIN2 Antibodies) and PTRF/cavin 1 colocalized.
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
polymerase I and transcript release factor
, leucine zipper protein
, leucine-zipper protein
, polymerase I and transcript release factor-like
, RNA polymerase I and transcript release factor
, TTF-I interacting peptide 12