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PIGR is a member of the immunoglobulin superfamily. Additionally we are shipping PIGR Antibodies (137) and PIGR Proteins (50) and many more products for this protein.
Showing 6 out of 22 products:
Human PIGR ELISA Kit for Sandwich ELISA - ABIN416843
Ohlmeier, Mazur, Linja-Aho, Louhelainen, Rönty, Toljamo, Bergmann, Kinnula: Sputum proteomics identifies elevated PIGR levels in smokers and mild-to-moderate COPD. in Journal of proteome research 2012
Show all 5 references for ABIN416843
Both pIgR and FcRn mRNA levels were significantly reduced in the duodenal mucosa during acute SHIV infection and in the jejunum and caecum during chronic SHIV/SIV infection.
The polymeric immunoglobulin receptor secretory component structure comprises five immunoglobulin-like domains (D1-D5) arranged as a triangle, with an interface between ligand-binding domains D1 and D5.
Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis.
Crohn disease patients were characterized as having decreased median expression of PIGR, in non-inflamed colonic mucosa. By contrast, Ulcerative colitis patients exhibited decreased expression of PIGR in colon mucosa.
These results demonstrate that SLPI (show SLPI ELISA Kits) down-regulates pIgR expression through the NF-kappaB (show NFKB1 ELISA Kits) signaling pathway by inhibiting degradation of IkappaBbeta (show NFKBIB ELISA Kits) protein.
Report PIGR expression in human fallopian tubes, primary epithelial ovarian tumours and metastases.
the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 (show STAT6 ELISA Kits) pathway activation.
Positive expression of pIgR was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis.
In conclusion these data suggest that Streptococcus pneumoniae PspC-promoted uptake via the polymeric immunoglobulin receptor of epithelial cells is mediated by both clathrin and caveolin dependent pathway.
Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma.
High PIGR expression independently predicts a decreased risk of recurrence and an improved survival in patients with adenocarcinoma of the upper gastrointestinal tract
This study evaluated the production of polymeric immunoglobulin receptor and immunoglobulin A in the salivary glands of cattle.
pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.
Increased autoimmune diabetes in Pigr-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.
In a mouse intestinal explant model, the heat-inactivated potential probiotic BB6378 increases intestinal pIgR expression in a site-specific manner on the epithelium via MyD88 (show MYD88 ELISA Kits).
pIgR on the blood-brain barrier endothelium may represent a novel pneumococcal adhesion receptor.
Results reveal a novel Yes-EGFR (show EGFR ELISA Kits)-ERK (show EPHB2 ELISA Kits)-FIP5 signalling network for regulation of pIgA (show PIGA ELISA Kits)-pIgR transcytosis.
Blockade of transepithelial transport of dimeric IgA in pIgR knockout mice reduces the degree of protection or cross-protection against viral infection, in parallel with a marked increase in serum IgA concentration and decrease in nasal IgA concentration.
Mice deficient in SIgA have been generated by knocking out the pIgR and assessing their ability to maintain normal mucosal homeostasis and to induce mucosal and systemic immune responses against pathogenic and nonpathogenic stimuli.
Mice that lack expression of the polymeric immunoglobulin receptor have approximately 5-fold more systemic IgA and 6-fold less nasal IgA antibodies than wild-type mice due to defective IgA transport into mucosal tissues.
Data suggest that the pIgR and/or the secretory component are important for the maintenance of epithelial integrity and mucosal homeostasis in the colonic epithelium.
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells\; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
polymeric immunoglobulin receptor
, polymeric immunoglobulin receptor-like
, poly-Ig receptor
, polymeric IgA receptor
, hepatocellular carcinoma associated protein TB6
, hepatocellular carcinoma-associated protein TB6
, phosphatidylinositol glycan, class R
, poly-IG receptor