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The protein encoded by PNPT1 belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. Additionally we are shipping Polyribonucleotide Nucleotidyltransferase 1 Antibodies (73) and many more products for this protein.
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this study provides further evidence that hPNPase(old-35) is associated with global changes in cell cycle-associated genes and identifies potential gene targets for future investigation
fresh insight into cellular pathways regulated by PNPT1
Interaction between PNPase and hSuv3 is essential for efficient mitochondrial RNA degradation.
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory-chain deficiency.
a novel role of nEGFR in radioresistance, and that is, upon ionizing radiation, nEGFR inactivates the ribonuclease activity of PNPase toward c-MYC (show MYC Proteins) mRNA through DNAPK (show PRKDC Proteins)-mediated Ser (show SIGLEC1 Proteins)-776 phosphorylation
targeted overexpression of hPNPase(old-35) represents a novel strategy to selectively downregulate RNA expression and consequently intervene in a variety of pathophysiological conditions
The data support an unanticipated role for PNPASE in mediating the translocation of RNAs into mitochondria.
Inhibition of PNPase by shRNA or stable overexpression of miR (show MLXIP Proteins)-221 protected melanoma cells from IFN-beta (show IFNB1 Proteins)-mediated growth inhibition, accentuating the importance of PNPase induction and miR (show MLXIP Proteins)-221 down-regulation in mediating IFN-beta (show IFNB1 Proteins) action.
Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring
The data support an unanticipated role for PNPASE in mediating the translocation of RNAs into mitochondria
The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7.
polyribonucleotide nucleotidyltransferase 1, mitochondrial
, 3'-5' RNA exonuclease OLD35
, PNPase 1
, PNPase old-35
, polynucleotide phosphorylase 1
, polynucleotide phosphorylase-like protein